An Interdisciplinary Molecular Metabolism Training Program

跨学科分子代谢培训计划

• 批准号: 10628345
• 负责人: Matthew J Brady
• 金额: $ 16.14万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628345
• 关键词: Metabolism; Molecular; Training Programs

PROJECT SUMMARY Metabolic disease is a massive worldwide health problem as illustrated by the current epidemics in obesity and type 2 diabetes, which is especially prominent in the United States and showing no sign of abating. As such, there is an urgent need for metabolism research to face this alarming situation. However, there are relatively few training programs across the country specifically dedicated to the training of bright young predoctoral researchers in metabolism at the systemic, cellular and molecular level. To address this need we have set up the Molecular Metabolism Training Program (MMTP) at the University of Chicago, which incorporates the Committee on Molecular Metabolism & Nutrition (CMMN) and thus is one of the few graduate programs in the United States granting a PhD in molecular metabolism. A successful training program in metabolism requires a multi- and inter-disciplinary approach, made up of researchers with a wide variety of technical skills and research experience. The MMTP takes advantage of the marvelous and highly interactive biomedical environment and strong traditions in metabolic and diabetes research at the University of Chicago. The trainers in the MMTP, in whose laboratories MMTP trainees will conduct their research projects, have primary appointments across many departments and sections of the Biological Sciences Division, but have a unifying interest in understanding the causes and potential therapies for type 1 and type 2 diabetes, from molecular, metabolic and/or immunologic viewpoints. Being interdepartmental, the MMTP pre-doctoral trainees can take courses and gain experience in Biochemistry, Molecular Biology, Cell Biology, Genetics, Medicine, Immunology, Physiology and Neurobiology with a required comprehensive specialized metabolism core- curriculum. Trainees must also attend metabolism journal clubs, data sessions, seminar series, and an annual multi-disciplinary retreat. Participation in National and International metabolism, diabetes and/or obesity scientific meetings is expected. There is strong institutional support, as well as a significant allocation of new research space and equipment for the MMTP. Many outstanding applicants currently apply to the CMMN and Biomedical Science Cluster (Immunology, Microbiology and Cancer Biology), and the recruitment success rate into these programs is high. Pre-doctoral trainees recently graduated from the CMMN have found postdoctoral positions in foremost academic metabolism research laboratories and some have moved on to establish their own academic research groups, which we expect to continue under the MMTP. The ultimate goal of the MMTP is to set up young researchers on the path to become independent academic diabetes research scientists and mentors themselves – dedicated to excellent scholarship and making breakthrough discoveries in that will lead to new therapies to better treat, prevent and perhaps even cure these disorders.

项目摘要 代谢性疾病是一个巨大的全球性健康问题，如目前肥胖和肥胖症的流行所示。 2型糖尿病，在美国尤为突出，而且没有减弱的迹象。因此，在本发明的一个方面， 迫切需要代谢研究来面对这种令人担忧的情况。然而，相对而言， 全国各地专门致力于培养聪明的年轻博士预科生的培训计划很少 研究人员在代谢系统，细胞和分子水平。为了满足这一需求，我们建立了 芝加哥大学的分子代谢培训计划（MMTP），其中包括 分子代谢与营养委员会（CMMN），因此是少数几个研究生课程之一， 美国授予分子代谢博士学位。一个成功的新陈代谢训练计划需要 多学科和跨学科的方法，由具有各种技术技能的研究人员组成， 研究经验。MMTP利用了奇妙的和高度互动的生物医学 芝加哥大学在代谢和糖尿病研究方面的环境和强大传统。培训员 在MMTP中，MMTP学员将在其实验室进行研究项目， 生物科学部的许多部门和部门的任命，但有一个统一的 有兴趣了解1型和2型糖尿病的原因和潜在的治疗方法，从分子， 代谢和/或免疫学观点。作为跨部门，MMTP博士预科学员可以参加 课程和生物化学，分子生物学，细胞生物学，遗传学，医学， 免疫学，生理学和神经生物学，具有所需的全面专业代谢核心- 课程。学员还必须参加新陈代谢杂志俱乐部，数据会议，研讨会系列，和年度 多学科静修参与国家和国际代谢，糖尿病和/或肥胖 预计将举行科学会议。有强大的机构支持，以及大量的新分配， MMTP的研究空间和设备。许多优秀的申请人目前申请CMMN， 生物医学科学集群（免疫学，微生物学和癌症生物学），以及招聘成功率 这些项目的成本很高。最近从CMMN毕业的博士前实习生已经找到了博士后 在最重要的学术代谢研究实验室的职位，有些已经转移到建立他们的 我们有自己的学术研究小组，我们希望在MMTP下继续进行。MMTP的最终目标 是建立年轻的研究人员的道路上成为独立的学术糖尿病研究科学家， 导师自己-致力于优秀的奖学金，并取得突破性的发现，这将导致 新的疗法来更好地治疗，预防甚至治愈这些疾病。