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Training program in the biology and translational research on Alzheimer's diseaseand related dementias

阿尔茨海默病和相关痴呆症的生物学和转化研究培训计划

基本信息

批准号：
10628893
负责人：
Stephanie M Cologna
金额：
$ 33.06万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628893
关键词：
Alzheimer&apos s Disease Biology Dementia Training Programs Translational Research

项目摘要

Project Summary This T32 renewal application seeks support for the multidisciplinary education of trainees in Alzheimer’s disease and Related Dementia (ADRD). The goal of this program is to train the next generation of creative and meritorious ADRD researchers at the predoctoral level. We acknowledge that the development of future therapy for dementia will require strong training in multiple disciplines, such as, the molecular biology of dementia, drug discovery and development, clinical studies and the analysis of large data sets. We will answer the imperative need for scientists who can synthesize across disciplines. Our Training Program comprises of four discplines/themes: (1) biological mechanisms (2) drug discovery and development (3) clinical ADRD (4) computational science. Each student gets trained in at least two of the four disciplines, utilizing a multidisciplinary approach for tackling scientific questions in ADRD. Attentive to the latest recommendation of the NIA and Alzheimer’s Association guidelines, there will be special emphasize on the analysis of lifestyle, environmental factors and preventative approaches for ADRD. The mentor/preceptor team has outstanding expertise to establish this innovative, interdisciplinary training program, to integrate otherwise disparate centers of excellence at UIC and Rush, leveraged by industry collaborations. Preceptor expertise is diverse; from molecular mechanisms of dementia, vascular biology, diabetes and inflammation, neuronal and neural imaging to clinical diagnosis of human ADRD patients and large scale data analysis. Expertise is from 12 departments and 6 clinical and translational entities. We will train ADRD researchers with diverse backgrounds and cross- disciplinary skills, including neuroscientists, but also computational biologists, chemists, and engineers interested in translational ADRD research. To facilitate interdisciplinary training, trainees will have two preceptors from different disciplines. We will build individual development plans (IDPs) for each trainee and offer multidisciplinary coursework from ADRD-TP faculty and pharma scientists. Importantly, trainees can perform translational research at any of the affiliated clinical and translational entities. Trainees will be encouraged to collaborate with large community-based NIH-supported studies (ROS/MAP) or NIA’s large-scale collaborative consortia (AMP-AD, M2OVE-AD, ADNI, ACTC), and with our pharma partners, Eli Lilly, Abbott and Baxter. Trainees are encouraged to participate in workshops geared towards -omics and drug discovery and the CIM/MATTER entrepreneurial program that aids commercialization of scientific innovation. We seek to support 6 predoctoral trainees. The success of this program in the last five years is reflected by our alumni who have moved on to successful careers in academia and pharma. The ADRD-TP’s vitality is reflected by the numbers of highly qualified applicants and state-of-the-art scientific endevours and publications. We expect the next five year to surpass this success. In summary, the ADRD-TP will provide a rigorous, inspiring and nurturing environment to ensure training of the highest level of scientists needed to unravel dementia.

项目摘要此T32更新申请寻求对阿尔茨海默病学员多学科教育的支持相关痴呆症（ADRD）该计划的目标是培养下一代创造性和优秀的ADRD研究人员在博士前水平。我们承认未来治疗的发展痴呆症的治疗需要多个学科的强有力的培训，如痴呆症的分子生物学，药物治疗，发现和开发，临床研究和大型数据集的分析。我们会回答需要能够跨学科综合的科学家。我们的培训计划包括四个学科/主题：（1）生物学机制（2）药物发现和开发（3）临床ADRD（4）计算科学每个学生得到至少在四个学科中的两个培训，利用多学科解决ADRD中科学问题的方法。注意NIA的最新建议，老年痴呆症协会的指南中，会特别强调对生活方式、环境的分析 ADRD的因素和预防方法。导师/导师团队具有出色的专业知识，建立这种创新的跨学科培训计划，以整合其他不同的卓越中心在UIC和Rush，通过行业合作来利用。导师的专业知识是多样化的;从分子痴呆的机制，血管生物学，糖尿病和炎症，神经元和神经成像，以临床人类ADRD患者的诊断和大规模数据分析。专业知识来自12个部门和6个临床和翻译实体。我们将培养具有不同背景和跨学科的ADRD研究人员- 学科技能，包括神经科学家，但也计算生物学家，化学家和工程师对转化型ADRD研究感兴趣。为了促进跨学科的培训，学员将有两名导师来自不同的学科。我们将为每位学员制定个人发展计划（IDP），并提供 ADRD-TP教师和制药科学家的多学科课程。重要的是，学员可以在任何附属的临床和转化实体进行转化研究。将鼓励学员与基于社区的大型NIH支持的研究（ROS/MAP）或NIA的大规模合作联盟（AMP-AD、M2 OVE-AD、ADNI、ACTC）以及我们的制药合作伙伴礼来、雅培和巴克斯特。鼓励学员参加针对组学和药物发现以及 CIM/MATTER创业计划，帮助科学创新的商业化。我们寻求支持 6名博士生。该计划在过去五年中的成功反映在我们的校友中，后来在学术界和制药业取得了成功ADRD-TP的活力反映在数字上高素质的申请人和最先进的科学研究和出版物。我们预计未来五年年，超越这一成功。总之，ADRD-TP将提供一个严格的，鼓舞人心的和培养环境，以确保培训最高水平的科学家需要解开痴呆症。