Helium Recycling for UIC Nuclear Magnetic Resonance
Helium Recycling for UIC Nuclear Magnetic Resonance
批准号:
10533681
负责人:
Stephanie M Cologna
金额:
$35.09万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-08-01 至 2023-07-31
关键词:
AddressApplied ResearchAtmosphereBiomedical ResearchBiophysicsChicagoCommunitiesCore FacilityDevelopmentElectron MicroscopyEngineeringEnsureEnvironmental ImpactFundingGasesGeometryGoalsHealthHeliumIllinoisInstitutionLaboratoriesLiquid substanceMaintenanceManualsMass Spectrum AnalysisModernizationMonitorNatural ResourcesNuclear Magnetic ResonancePlumbingProteinsRadioactiveRecoveryRecyclingResearch PersonnelResearch SupportResourcesSiteStructureSystemTechniquesUniversitiesVendorWorkX-Ray Crystallographybasecold temperaturecostcost effectivenesscryogenicsdesigndrug discoveryinstrumentinstrumentationoperationpressurequantumresponsesmall moleculesolid statestructural biologytime use
中文摘要
项目总结
英文摘要
Project summary
Nuclear magnetic resonance (NMR) is a critical technique for characterization of small molecules such as
proteins, including their structure, dynamics monitoring and quantitative analysis, among others. For proper
operation of NMR instrumentation, cryogenic liquids such as helium are necessary to maintain low
temperatures required for operation. Helium is a limited natural resource and much of the cryogenic liquid used
for instruments such as NMR is released to the atmosphere during both routine operation and occasional
magnet fills. To address this issue, commercial vendors have developed helium gas capture and recycling
systems to be able to address the boil off loss. At the University of Illinois Chicago (UIC), our shared NMR
instrument core, located in the Center for Structural Biology, houses three NMR spectrometers with an
additional instrument planned for installation in the coming months. Thus, this facility demands substantial
liquid helium, which is both costly and uses a depleting natural resource. In response to this funding
announcement, we are proposing to prepare the site and install a helium recycling unit that has multi-
instrument capabilities in the Center for Structural Biology. The addition of this new system will streamline our
operations, modernize our facility and enable an increased user base for this shared facility.
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会议论文
Clinically Relevant Biomarkers for Niemann-Pick Type C
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批准号:10837461
-
项目类别:
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资助金额:$38.38万
-
财政年份:2023
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负责人:Stephanie M Cologna
-
依托单位:
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项目类别:
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资助金额:$38.56万
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财政年份:2020
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负责人:Stephanie M Cologna
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依托单位:
Training program in the biology and translational research on Alzheimer's diseaseand related dementias
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批准号:10628893
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项目类别:
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资助金额:$33.06万
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财政年份:2017
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负责人:Stephanie M Cologna
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依托单位:
海外基金