Shared Resource Management

共享资源管理

Abstract Shared Resource Management The COHCCC Shared Resources play a vital role in support of the cancer-focused research of all five programs within the CC, spanning the translational pipeline from the earliest phase of discovery to the manufacture of new biologics, cell therapeutics, and small molecules for preclinical and Phase 1 studies. Specific Aims for SRM: Aim 1. Provide centralized SR leadership and oversight to meet the scientific needs of COHCCC Members. Aim 2. Implement effective, standardized policies and practices that govern the use and evaluation of SRs. Aim 3. Respond to the current and future scientific needs of COHCCC Members via targeted enhancements to SR infrastructure, services, and operations. The Shared Resources management structure oversees all operational aspects including equipment acquisition and maintenance, billing, staffing, informational seminars, and consistent monitoring of service quality and operational efficiency. This is accomplished via cooperative interactions between the SR Directors, their respective Advisory Committees (SRAC), the Shared Resources Steering Committee (SRSC), Shared Resources Administration (SRA), and the AD for Shared Resources. User feedback is provided from multiple inputs, through formal and informal mechanisms, and provides the basis for continual surveying of all aspects of COHCCC SR operations. Changes in service lines, SR leadership, and addition of new SRs are finalized under the direction of the COHCCC Director and COHCCC EC working in conjunction with the AD, SRSC, and SRM with the goal of constant improvement. Since the last review, significant changes have included complete integration of SRs between COH and TGen, enhancement of high throughput screening and digital imaging services, inclusion of mathematical oncology under biostatistics (BMOC), and significant upgrades in services and leadership structure for both Integrated Mass Spectrometry (IMS) and Research Pathology (RP). A Clinical Microbiome (CMB) SR is proposed as a new CCSG resource to enhance collaborative interactions between COH and TGen CCC faculty, and complement existing SRs in support of the strategic goals of the cancer center. Aggregate of all CCSG Cores: Members Utilization by %Revenue 2017–21: 92.7 Total (14.5 MCBC, 13 DCT, 26.5 CI, 32.1 HM, 6.6 CCPS,) Publications by Members: 637, 180 with Impact Factor >10 Grants Supported: 303 Total (7 ACS, 17 CIRM, 19 DoD, 7 LLS, 139 NCI of 226 NIH (1 P01, 145 R01, 12 U01))