Shared Resource Management

共享资源管理

• 批准号: 10628581
• 负责人: JOHN S TERMINI
• 金额: $ 14.55万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628581
• 关键词: Admixture; Advisory Committees; Biological Products; Biometry; Biostatistics Shared Resource; Breast; Cancer Center; Cancer Center Support Grant; Cells; City of Hope Comprehensive Cancer Center; Clinical; Clinical Treatment; Collaborations; Complement; Comprehensive Cancer Center; Core Facility; DNA sequencing; Data; Doctor of Philosophy; Ecosystem; Equipment; Evaluation; Faculty; Feedback; Future; Genetic; Genomics; Goals; Grant; Health Disparities Research; Image; Image Cytometry; Infrastructure; Leadership; Maintenance; Malignant Neoplasms; Maps; Mass Spectrum Analysis; Mathematics; Mission; Modeling; Monitor; NCI Center for Cancer Research; Oncology; Pathology; Pathway interactions; Phase; Play; Policies; Population; Precision Medicine Initiative; Production; Publications; Research; Research Activity; Resource Sharing; Resources; Review Committee; Robotics; Role; Services; Standardization; Structure; Surveys; Technology; The Jackson Laboratory; Therapeutic; Tissue imaging; United States National Institutes of Health; assay development; cancer initiation; cancer research center director; data management; digital imaging; drug discovery; equipment acquisition; experience; high throughput screening; humanized mouse; imaging facilities; imaging platform; improved; insight; instrument; interdisciplinary collaboration; light microscopy; manufacture; mass spectrometry shared resource; member; microbiome; microscopic imaging; mouse model; nano-string; novel; operation; phase 1 study; pre-clinical; programs; recruit; screening; small molecule; small molecule libraries; structural biology; translational pipeline; vector

Abstract Shared Resource Management The COHCCC Shared Resources play a vital role in support of the cancer-focused research of all five programs within the CC, spanning the translational pipeline from the earliest phase of discovery to the manufacture of new biologics, cell therapeutics, and small molecules for preclinical and Phase 1 studies. Specific Aims for SRM: Aim 1. Provide centralized SR leadership and oversight to meet the scientific needs of COHCCC Members. Aim 2. Implement effective, standardized policies and practices that govern the use and evaluation of SRs. Aim 3. Respond to the current and future scientific needs of COHCCC Members via targeted enhancements to SR infrastructure, services, and operations. The Shared Resources management structure oversees all operational aspects including equipment acquisition and maintenance, billing, staffing, informational seminars, and consistent monitoring of service quality and operational efficiency. This is accomplished via cooperative interactions between the SR Directors, their respective Advisory Committees (SRAC), the Shared Resources Steering Committee (SRSC), Shared Resources Administration (SRA), and the AD for Shared Resources. User feedback is provided from multiple inputs, through formal and informal mechanisms, and provides the basis for continual surveying of all aspects of COHCCC SR operations. Changes in service lines, SR leadership, and addition of new SRs are finalized under the direction of the COHCCC Director and COHCCC EC working in conjunction with the AD, SRSC, and SRM with the goal of constant improvement. Since the last review, significant changes have included complete integration of SRs between COH and TGen, enhancement of high throughput screening and digital imaging services, inclusion of mathematical oncology under biostatistics (BMOC), and significant upgrades in services and leadership structure for both Integrated Mass Spectrometry (IMS) and Research Pathology (RP). A Clinical Microbiome (CMB) SR is proposed as a new CCSG resource to enhance collaborative interactions between COH and TGen CCC faculty, and complement existing SRs in support of the strategic goals of the cancer center. Aggregate of all CCSG Cores: Members Utilization by %Revenue 2017–21: 92.7 Total (14.5 MCBC, 13 DCT, 26.5 CI, 32.1 HM, 6.6 CCPS,) Publications by Members: 637, 180 with Impact Factor >10 Grants Supported: 303 Total (7 ACS, 17 CIRM, 19 DoD, 7 LLS, 139 NCI of 226 NIH (1 P01, 145 R01, 12 U01))

抽象共享资源管理 COHCCC共享资源在支持所有五个项目以癌症为重点的研究方面发挥着至关重要的作用 在CC内，从最早的发现阶段到新产品的制造，跨越翻译管道 用于临床前和第一阶段研究的生物制剂、细胞治疗药物和小分子药物。 SRM的具体目标： 目标1.提供集中的SR领导和监督，以满足COHCCC的科学需求 会员。 目标2.实施有效、标准化的政策和做法，管理使用和评价 SRS。 目标3.通过有针对性地满足COHCCC成员当前和未来的科学需求 增强了SR基础架构、服务和运营。 共享资源管理结构监督所有业务方面，包括设备采购 和维护、计费、人员配备、信息研讨会以及对服务质量和 运营效率。这是通过SR Director、他们的 各自的咨询委员会(SRAC)、共享资源指导委员会(SRSC) 资源管理(SRA)和共享资源的AD。用户反馈来自多个 通过正式和非正式机制提供投入，并为持续调查以下各方面提供基础 COHCCC SR运营。服务线、服务请求领导层和添加新服务代表的更改将根据以下条款完成 COHCCC主任和COHCCC EC与AD、SRSC和SRM一起工作的指导 以不断改进为目标。自上次审查以来，重大变化包括完成 集成COH和TGen之间的SRS，增强高通量筛选和数字成像 服务，将数学肿瘤学纳入生物统计学(BMOC)，并对服务进行重大升级 以及集成质谱学(IMS)和研究病理学(RP)的领导结构。一家临床诊所 微生物组(CMB)SR是一种新的CCSG资源，用于增强 COH和TGen CCC教职员工，并补充现有的SRS，以支持癌症中心的战略目标。 所有CCSG核心的合计： 2017-21年度按收入百分比划分的成员利用率：总计92.7(14.5 MCBC、13 DCT、26.5 CI、32.1 HM、6.6 CCPS、) 会员出版物：637,180，含影响因子&>10 支持的拨款：总共303笔(7个ACS、17个CIRM、19个DoD、7个LLS、226个NIH的139个NCI(1个P01、145个R01、12个U01))