Administrative and Engagement Core

行政和参与核心

• 批准号: 10738104
• 负责人: DELIVETTE CASTOR
• 金额: $ 18.85万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10738104
• 关键词: Acceleration; Address; Affect; Black race; Cancer Control; Cancer Etiology; Cervical; Cervical Cancer Screening; Cessation of life; Clinical; Clinical Trials; Collaborations; Communities; Coordination and Collaboration; Country; Decision Making; Disease; Eligibility Determination; Ensure; Equity; Evidence based intervention; Food; Fostering; Generations; Goals; Government; Guidelines; HIV/TB; Health; Health Services; Healthcare; Home; Human Papillomavirus; Incidence; Inequity; Infrastructure; Iron; Knowledge; Lead; Leadership; Malignant neoplasm of cervix uteri; Mission; Performance; Persons; Prevention strategy; Primary Prevention; Productivity; Province; Public Health; Recommendation; Research; Research Personnel; Research Project Grants; Resource Sharing; Resource-limited setting; Resources; Rest; Safety; Scientific Advances and Accomplishments; Secondary Prevention; Seminal; Shapes; Site; South Africa; Testing; Unemployment; Universities; Vaccinated; Woman; Women' s Health; Wood material; World Health Organization; access disparities; aged; burden of illness; cancer health disparity; clinical care; community engagement; evidence base; experience; girls; global health; healing; health disparity; health inequalities; implementation research; implementation study; infection rate; low and middle-income countries; mortality; peri-urban; point of care; programs; response; scale up; screening; screening program; social; success; synergism; treatment duration; uptake

Our investigator team at Columbia University and the University of Cape Town, through a nearly thirty-year collaboration under the Khayelitsha Cervical Cancer Screening Program (KCCSP) have conducted some seminal clinical trials demonstrating the safety and efficacy of HPV-based SAT, both with treatment within 2-6 days and with on-site, same-day treatment.3-5 HPV-based SAT is included in South Africa’s national guidelines.6 Like most countries, South Africa is grappling with how to operationalize and promote equitable uptake and integration of HPV-based screening in public health and clinical care settings. Aligned with RFA-CA-22-019 the KCCSP has been formalizing its longstanding partnership with the Western Cape Department of Health (WCDoH) with the mission to accelerate the integration and scale-up of evidence-based interventions for equitable cervical cancer elimination among women in resource-constrained settings. Under this formal partnership, we propose the Empilisweni (a place of healing) Center for Women’s Health. The Center seeks to support the WHO’s global strategy to accelerate the elimination of cervical cancer by the end of this millennium by equitably integrating scalable, affordable HPV-based point-of-care screen-and-treat (HPV-POC) strategies, by fostering effective collaboration, coordination, decision-making, resource and knowledge sharing regionally, and building implementation capacity in local implementers, researchers, and stakeholder community. Success of the Center’s goals rest on the principles that shape strong administration and best practices for stakeholder engagement. MPIs; Denny (UCT), and Kuhn (CUIMC), who founded KCCSP, will be joined by MPI Castor (Contact: CUIMC), Mbatani (UCT), Saidu (UCT), and Arendse (UCT/WCDoH) in the daily management to ensure that the Center’s productivity, performance meet its goals. MPIs Shelton (CUIMC) and Tehranifar (CUIMC), who lead the capacity building core and research project 1, respectively, have experience in community engagement and will ensure that all aspects of the Center's responsibilities is met. The leadership team will be completed with the addition of another WCDoH collaborator, Dr. Cloete, who will ensure equitable representation of health services implementation in collaboration and coordination with stakeholders. Through this administrative and stakeholder engagement core, we propose to: 1) Strategically guide the Center’s efficiency, productivity, and success through administrative support, infrastructure, and program management that synergizes activities across the Center’s cores and projects; and 2) Foster effective collaboration, coordination, decision-making, knowledge and resource sharing across the Western Cape Province informed by best practices on community engagement and ongoing theoretically grounded qualitative and quantitative research and engagement from regional partners. By the end of five years, the Empilisweni Center will contribute to the scale-up of HPV-based SAT as part of the cervical cancer elimination goals through strategic management of the Center’s core and project activities for synergy, generation, and scientific advancement.

我们在哥伦比亚大学和开普敦大学的研究团队，经过近三十年的 Khayelitsha宫颈癌筛查计划（KCCSP）下的合作进行了一些 开创性的临床试验证明了基于HPV的SAT的安全性和有效性，两者的治疗范围均为2-6 3 -5基于HPV的SAT已纳入南非国家指南6。 与大多数国家一样，南非正在努力解决如何实施和促进公平吸收， 在公共卫生和临床护理环境中整合HPV筛查。与RFA-CA-22-019一致， KCCSP一直在正式确定与西开普省卫生部的长期合作伙伴关系 （WCDoH）的使命是加速整合和扩大循证干预措施， 在资源有限的环境中公平消除妇女宫颈癌。在这种形式下， 我们建议建立Empilisweni（一个治疗的地方）妇女健康中心。该中心力求 支持世卫组织在本千年末加速消除宫颈癌的全球战略 通过公平地整合可扩展的、负担得起的基于HPV的即时筛查和治疗（HPV-POC）策略， 通过促进区域有效合作、协调、决策、资源和知识共享， 以及建设当地执行者、研究人员和利益攸关方社区的执行能力。成功 中心的目标建立在为利益相关者塑造强有力的管理和最佳实践的原则之上 订婚MPI; Denny（UCT）和Kuhn（CUIMC），他们创立了KCCSP，将加入MPI Castor （联系人：CUIMC），Mbatani（UCT），Saidu（UCT）和Arendse（UCT/WCDoH）在日常管理中，以确保 该中心的生产力，性能达到其目标。MPI谢尔顿（CUIMC）和德黑兰法尔（CUIMC）， 分别领导能力建设核心和研究项目1，有社区参与经验 并将确保履行中心各方面的职责。领导班子将组建完成 随着另一位WCDoH合作者Cloete博士的加入，他将确保健康的公平代表性， 与利益攸关方合作和协调实施服务。通过这一行政和 利益相关者参与的核心，我们建议：1）战略指导中心的效率，生产力， 通过行政支持、基础设施和计划管理来实现活动的协同增效，从而取得成功 跨中心的核心和项目;和2）促进有效的合作，协调，决策， 通过社区最佳做法，在西开普省分享知识和资源 参与和正在进行的理论基础的定性和定量研究， 区域伙伴。到五年结束时，Empilisweni中心将为扩大基于HPV的 SAT作为消除宫颈癌目标的一部分，通过战略管理中心的核心， 项目活动的协同作用，发电和科学进步。