Investigating relationships between naturalistic light exposure and sleep

研究自然光照与睡眠之间的关系

• 批准号: 10739430
• 负责人: Danielle A. Wallace
• 金额: $ 16.59万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-05 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10739430
• 关键词: Address; Affect; Age; Area; Award; Behavior; Biological; Biological Markers; Body Temperature; Chronobiology; Circadian desynchrony; Clinical; Cohort Studies; Communities; Cues; DNA Methylation; Data; Data Analyses; Data Collection; Development; Development Plans; Dimensions; Disease; Drowsiness; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Epigenetic Process; Foundations; General Population; Genetic Materials; Goals; Grant; Health; Health Promotion; Health Status; Heart Rate; Hispanic Community Health Study/Study of Latinos; Humidity; Interdisciplinary Study; Intervention; Knowledge; Light; Linear Models; Link; Measurement; Measures; Mentors; Modeling; Molecular Epidemiology; Multi-Ethnic Study of Atherosclerosis; Mutation; Noise; Non-linear Models; Outcome; Participant; Pathway interactions; Patient Recruitments; Pattern; Phase; Population; Printing; Prospective cohort; Proxy; Public Health; Recording of previous events; Reporting; Research; Research Personnel; Role; Site; Sleep; Sleep Deprivation; Sleep disturbances; Statistical Data Interpretation; Statistical Models; Sum; System; Temperature; Training; United States National Institutes of Health; Vision research; Work; actigraphy; blood-based biomarker; candidate identification; cardiometabolism; career; career development; circadian; cohort; community setting; disorder prevention; genome-wide; high dimensionality; improvement on sleep; methylation biomarker; methylation pattern; molecular marker; multi-ethnic; novel; population health; programs; prospective; public health intervention; secondary analysis; sex; shift work; sleep health; successful intervention; tool

PROJECT SUMMARY Sleep irregularity is highly prevalent and linked to downstream adverse cardiometabolic health outcomes, but the upstream drivers of sleep irregularity are not well characterized. Adverse health outcomes associated with irregular sleep timing mirror those linked to shift work, and irregular sleep may represent a driver of circadian misalignment and related disease in the general population. Notably, sleep timing is modifiable and could serve as an inexpensive, non-invasive way to promote health, but further research on environmental factors influencing sleep regularity is required to inform successful interventions. Understanding the environmental drivers and molecular markers of irregular sleep are critical gaps that would aid public health intervention and disease prevention efforts. The recent 2021 NIH Sleep Research Plan highlights research on the effects of environmental exposures on sleep and on epigenetic mechanisms underlying sleep and circadian health as top priorities. Therefore, to address these gaps in knowledge and stated research needs, I propose to apply acquired training in sleep epidemiology, chronobiology, and advanced statistical analysis and epigenetics to: 1) investigate which dimensions of light exposure impact sleep regularity and moderation by factors such as age and sex (K99), 2) develop biological markers of sleep regularity (K99), 3) validate and establish the temporality of resulting findings with prospectively collected data (R00), and 4) expand measurement of light and environmental factors with prospectively collected data (R00). My goal is to establish an independent research program centered around how light and other environmental exposures affect sleep and chronobiology in population health. This proposed study and career development plan logically builds upon my training in environmental health, vision research, and molecular epidemiology, to gain expertise in light data analysis and collection, sleep epidemiology, chronobiology, advanced statistical modeling, and omics integration. With expert mentored guidance provided by Dr. Tamar Sofer, Dr. Susan Redline, and Dr. Frank Scheer, I will establish a unique interdisciplinary research program focusing on the interactions of the light environment and sleep. This award will provide key training in four areas: 1) sleep epidemiology; 2) clinical chronobiology; 3) integration and analysis of high-dimensional light and actigraphy data with omics data; and 4) professional development. This data collected during the R00 phase will also provide a strong foundation for R01 applications. This support provided by this award will allow me to launch a novel independent research program and address inherent gaps in our understanding of the role of naturalistic light exposure on sleep health in the general population.

项目摘要 睡眠不规则高度普遍，与下游不良心脏代谢健康结果有关，但是 睡眠不规则的上游驱动因素没有很好地表征。不利的健康结果 不规则的睡眠时机镜面镜子挂着与轮班工作相关的那些，不规则的睡眠可能代表昼夜节律的驾驶员 普通人群中的未对准和相关疾病。值得注意的是，睡眠时间是可修改的，可以 作为促进健康的廉价，无创的方法，但对环境因素的进一步研究 需要影响睡眠规律性以告知成功的干预措施。了解环境 不规则睡眠的驱动因素和分子标志物是有助于公共卫生干预和 疾病预防工作。 最近2021年NIH睡眠研究计划强调了有关环境暴露对的研究 睡眠和表观遗传机制的睡眠和昼夜节律作为首要任务。因此，要 解决这些知识和既定研究需求的差距，我建议在睡眠中应用获得的培训 流行病学，时间生物学和高级统计分析和表观遗传学：1） 光暴露的维度会影响年龄和性别等因素的睡眠规律性和适度性（K99），2） 开发睡眠规律性的生物标记（K99），3）验证并确定结果的时间性 具有前瞻性收集数据的发现（R00），以及4）扩展光和环境的测量 前瞻性收集数据的因素（R00）。 我的目标是建立一个围绕光和其他环境的独立研究计划 暴露会影响人口健康中的睡眠和时间生物学。这项拟议的研究和职业发展 从逻辑上讲，计划基于我在环境健康，视觉研究和分子流行病学方面的培训， 获得光数据分析和收集，睡眠流行病学，年代生物学，高级统计学方面的专业知识 建模和OMICS集成。在塔玛·索弗（Tamar Sofer）博士Susan博士提供的专家指导下 Redline和Frank Scheer博士，我将建立一个独特的跨学科研究计划，重点是 轻度环境和睡眠的相互作用。该奖项将在四个领域提供关键培训：1）睡眠 流行病学； 2）临床时间生物学； 3）高维光和动作法的整合和分析 使用OMICS数据的数据； 4）专业发展。在R00阶段收集的此数据也将 为R01应用程序提供了强大的基础。该奖项提供的支持将使我能够发起 新颖的独立研究计划并解决了我们对自然主义作用的理解中固有的差距 普通人群的睡眠健康暴露。