Investigating relationships between naturalistic light exposure and sleep

研究自然光照与睡眠之间的关系

基本信息

  • 批准号:
    10739430
  • 负责人:
  • 金额:
    $ 16.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-05 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Sleep irregularity is highly prevalent and linked to downstream adverse cardiometabolic health outcomes, but the upstream drivers of sleep irregularity are not well characterized. Adverse health outcomes associated with irregular sleep timing mirror those linked to shift work, and irregular sleep may represent a driver of circadian misalignment and related disease in the general population. Notably, sleep timing is modifiable and could serve as an inexpensive, non-invasive way to promote health, but further research on environmental factors influencing sleep regularity is required to inform successful interventions. Understanding the environmental drivers and molecular markers of irregular sleep are critical gaps that would aid public health intervention and disease prevention efforts. The recent 2021 NIH Sleep Research Plan highlights research on the effects of environmental exposures on sleep and on epigenetic mechanisms underlying sleep and circadian health as top priorities. Therefore, to address these gaps in knowledge and stated research needs, I propose to apply acquired training in sleep epidemiology, chronobiology, and advanced statistical analysis and epigenetics to: 1) investigate which dimensions of light exposure impact sleep regularity and moderation by factors such as age and sex (K99), 2) develop biological markers of sleep regularity (K99), 3) validate and establish the temporality of resulting findings with prospectively collected data (R00), and 4) expand measurement of light and environmental factors with prospectively collected data (R00). My goal is to establish an independent research program centered around how light and other environmental exposures affect sleep and chronobiology in population health. This proposed study and career development plan logically builds upon my training in environmental health, vision research, and molecular epidemiology, to gain expertise in light data analysis and collection, sleep epidemiology, chronobiology, advanced statistical modeling, and omics integration. With expert mentored guidance provided by Dr. Tamar Sofer, Dr. Susan Redline, and Dr. Frank Scheer, I will establish a unique interdisciplinary research program focusing on the interactions of the light environment and sleep. This award will provide key training in four areas: 1) sleep epidemiology; 2) clinical chronobiology; 3) integration and analysis of high-dimensional light and actigraphy data with omics data; and 4) professional development. This data collected during the R00 phase will also provide a strong foundation for R01 applications. This support provided by this award will allow me to launch a novel independent research program and address inherent gaps in our understanding of the role of naturalistic light exposure on sleep health in the general population.
项目摘要 睡眠不规律非常普遍,与下游不良心脏代谢健康结果有关, 睡眠不规律的上游驱动因素没有得到很好的表征。与下列因素相关的不良健康结果 不规律的睡眠时间反映了那些与轮班工作有关的人,而不规律的睡眠可能代表了昼夜节律的驱动因素。 一般人群中的失调和相关疾病。值得注意的是,睡眠时间是可以修改的, 作为一种廉价,非侵入性的方式来促进健康,但进一步研究环境因素, 影响睡眠规律是成功干预的必要条件。了解环境 睡眠不规律的驱动因素和分子标志物是有助于公共卫生干预的关键差距, 疾病预防工作。 最近的2021年NIH睡眠研究计划强调了环境暴露对睡眠的影响。 睡眠和睡眠和昼夜健康的表观遗传机制作为首要任务。因此 为了解决这些知识上的差距和既定的研究需求,我建议在睡眠中应用后天训练 流行病学,时间生物学,先进的统计分析和表观遗传学:1)调查 光暴露的维度影响睡眠规律性和适度的因素,如年龄和性别(K99),2) 开发睡眠规律的生物标志物(K99),3)验证并建立结果的时间性 研究结果与前瞻性收集的数据(R 00),和4)扩大测量的光和环境 前瞻性收集数据的因素(R 00)。 我的目标是建立一个独立的研究计划,围绕光和其他环境如何 暴露会影响人口健康中的睡眠和时间生物学。本建议的学习和职业发展 计划逻辑上建立在我在环境健康,视觉研究和分子流行病学方面的培训基础上, 获得光数据分析和收集,睡眠流行病学,时间生物学,高级统计 建模和组学集成。在Tamar Sofer博士提供的专家指导下,Susan博士 Redline和Frank Scheer博士,我将建立一个独特的跨学科研究计划,重点是 光环境和睡眠的相互作用。该奖项将提供四个领域的关键培训:1)睡眠 流行病学; 2)临床时间生物学; 3)高维光和活动记录的整合和分析 数据与组学数据;和4)专业发展。在R 00阶段收集的数据还将 为R 01应用提供了坚实的基础。这个奖项提供的支持将使我能够发起一个 新颖的独立研究计划,并解决我们对自然主义的作用的理解中固有的差距 光暴露对一般人群睡眠健康的影响。

项目成果

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Danielle A. Wallace其他文献

Associations between evening shift work, irregular sleep timing, and gestational diabetes in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b)
未产儿妊娠结局研究中夜班工作、不规则睡眠时间和妊娠糖尿病之间的关联:监测准妈妈 (nuMoM2b)
  • DOI:
    10.1101/2022.05.23.22274967
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5.6
  • 作者:
    Danielle A. Wallace;K. Reid;W. Grobman;F. Facco;R. Silver;G. Pien;J. Louis;P. Zee;S. Redline;T. Sofer
  • 通讯作者:
    T. Sofer
Untargeted metabolome atlas for sleep-related phenotypes in the Hispanic community health study/study of Latinos
  • DOI:
    10.1016/j.ebiom.2024.105507
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Ying Zhang;Brian W. Spitzer;Yu Zhang;Danielle A. Wallace;Bing Yu;Qibin Qi;Maria Argos;M Larissa Avilés-Santa;Eric Boerwinkle;Martha L. Daviglus;Robert Kaplan;Jianwen Cai;Susan Redline;Tamar Sofer
  • 通讯作者:
    Tamar Sofer
Characteristics of objectively-measured naturalistic light exposure patterns in U.S. adults: A cross-sectional analysis of two cohorts
美国成年人客观测量的自然采光模式特征:两个队列的横断面分析
  • DOI:
    10.1016/j.scitotenv.2025.178839
  • 发表时间:
    2025-03-15
  • 期刊:
  • 影响因子:
    8.000
  • 作者:
    Danielle A. Wallace;Kelly R. Evenson;Carmen R. Isasi;Sanjay R. Patel;Daniela Sotres-Alvarez;Phyllis C. Zee;Susan Redline;Frank A.J.L. Scheer;Tamar Sofer
  • 通讯作者:
    Tamar Sofer
Methylation risk score of C-reactive protein associates sleep health with related health outcomes
C 反应蛋白的甲基化风险评分将睡眠健康与相关健康结果联系起来
  • DOI:
    10.1038/s42003-025-08226-1
  • 发表时间:
    2025-05-28
  • 期刊:
  • 影响因子:
    5.100
  • 作者:
    Ziqing Wang;Danielle A. Wallace;Brian W. Spitzer;Tianyi Huang;Kent D. Taylor;Jerome I. Rotter;Stephen S. Rich;Peter Y. Liu;Martha L. Daviglus;Lifang Hou;Alberto R. Ramos;Sonya Kaur;J. Peter Durda;Hector M. González;Myriam Fornage;Susan Redline;Carmen R. Isasi;Tamar Sofer
  • 通讯作者:
    Tamar Sofer

Danielle A. Wallace的其他文献

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{{ truncateString('Danielle A. Wallace', 18)}}的其他基金

Investigating the Impacts of in utero Circadian Disruption on Epigenetic Regulation of Metabolism and Diabetes
研究子宫内昼夜节律紊乱对代谢和糖尿病表观遗传调节的影响
  • 批准号:
    10000943
  • 财政年份:
    2018
  • 资助金额:
    $ 16.59万
  • 项目类别:

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