Developing, Refining, and Testing a Mobile Health Question Prompt List in Gastroesophageal Reflux Disease
开发、完善和测试胃食管反流病移动健康问题提示表
基本信息
- 批准号:10739903
- 负责人:
- 金额:$ 19.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AcidsAddressAdherenceAmericanBarrett EsophagusBehavioralClinicalClinical TrialsCommunicationCommunitiesDataDevelopmentDiseaseDoseEmpathyEsophageal AdenocarcinomaEsophageal DiseasesEsophagusFaceFeedbackFocus GroupsFoundationsFundingFutureGastroenterologyGastroesophageal reflux diseaseGoalsHealthHealth StatusHealthcareIndividualInfrastructureInterventionK-Series Research Career ProgramsKnowledgeManuscriptsMeasuresMedicalMentorshipMethodologyMethodsMobile Health ApplicationModelingOutcomePaperPatient-Focused OutcomesPatientsPhysiciansPilot ProjectsPopulation HeterogeneityProcessProtocols documentationQualitative MethodsQuality of lifeRandomizedResearchResourcesRiskRoleSamplingSeveritiesShapesSocioeconomic StatusSymptomsSystemTestingThinkingTimeTranslatingUpdateVisitWorkbehavior changecareer developmentclinical carecommunity settingcostdesigneffective interventionefficacy testingexperiencehealth care service utilizationhealth related quality of lifeideationimplementation scienceimprovedinnovationinsightmHealthmedication compliancemobile applicationmotivated behaviorpersistent symptompilot testprimary outcomeprototypereduce symptomssecondary outcomeskillsstandard of caresuccessusabilityuser centered design
项目摘要
Project Summary
Up to 42% of Americans with gastroesophageal reflux disease (GERD) experience uncontrolled, chronic
symptoms that reduce health-related quality of life and heighten the risk of long-term complications. My long-
term goal is to improve health outcomes for patients with esophageal disorders. This proposal aims to improve
health outcomes for patients with GERD, by harnessing patient activation and motivating behavioral change as
a framework for a mobile health (mHealth) Question Prompt List (QPL) intervention. Patient activation
emphasizes patients’ knowledge, skills, and confidence in managing their health care and predicts patients’
level of health success. However, almost half of patients with GERD demonstrate low patient activation scores.
Low patient activation leads to poor adherence to medical therapy. Remarkably, very little research has
focused on developing an intervention to improve patient activation and motivate behavior change in GERD.
Emerging evidence suggests effective patient-physician communication interventions, such as disease-specific
QPLs, increase patient activation. The objective of this proposal is to apply a 5-step user-centered Design
Thinking model to develop, refine, and test a mobile app based QPL specific for GERD patients titled
“Esophagus-Qs.” The central hypothesis is that Esophagus-Qs will be usable and has potential to harness
patient activation and motivate behavior change. Our specific aims include: 1) Develop the design of
Esophagus-Qs by empathizing, defining the problems patients face, and ideating to generate solutions; 2)
Refine the design of Esophagus-Qs by prototyping and testing usability; and 3) Collect preliminary data on
Esophagus-Qs in a randomized controlled pilot study to estimate the effect size of the intervention. We will
pursue these aims using an innovative combination of qualitative and quantitative methodologies and
implementation science to inform app development. The proposed research is significant, because it has
potential to harness patient activation and motivate behavior change, that can translate into improved health
outcomes. It is also significant because it will develop a platform that can be extended to develop mHealth
QPLs in other esophageal disorders. The proximate expected outcome of this work is to develop a usable
Esophagus-Qs and collect preliminary data on differences in patient activation over time, medication
adherence, health-related quality of life, and GERD symptom severity between Esophagus-Qs and standard of
care. Pilot data from this career development award will be the foundation for an R01-funded clinical trial to
rigorously test the efficacy of Esophagus-Qs among a large, diverse population.
项目摘要
高达42%的美国胃食管反流病(GERD)患者经历不受控制的慢性
降低健康相关生活质量和增加长期并发症风险的症状。我的长-
长期目标是改善食管疾病患者的健康结果。这项建议旨在改善
GERD患者的健康结果,通过利用患者激活和激励行为改变,
移动的健康(mHealth)问题提示列表(QPL)干预的框架。患者激活
强调患者的知识,技能和管理他们的医疗保健的信心,并预测患者的
健康成功的水平。然而,几乎一半的GERD患者表现出较低的患者激活评分。
低患者激活导致对药物治疗的依从性差。值得注意的是,很少有研究
专注于开发一种干预措施,以改善患者的激活和激励GERD的行为改变。
新出现的证据表明,有效的医患沟通干预措施,如疾病特异性
QPL,增加患者激活。本提案的目标是应用以用户为中心的5步设计
用于开发、完善和测试特定于GERD患者的基于移动的应用程序的QPL的思维模型,
“食道-Q”中心假设是,食道-Qs将是可用的,并有潜力利用
患者激活和激励行为改变。我们的具体目标包括:1)开发设计
食管-通过同情,定义患者面临的问题,并构思产生解决方案的问题; 2)
通过原型设计和可用性测试完善食管-Qs的设计;以及3)收集以下方面的初步数据:
食管-Qs在一项随机对照初步研究中估计干预的效应量。我们将
采用创新的定性和定量方法组合来实现这些目标,
实施科学为应用程序开发提供信息。这项研究意义重大,因为它
利用患者激活和激励行为改变的潜力,这可以转化为改善健康
结果。它也很重要,因为它将开发一个平台,可以扩展到发展mHealth
其他食管疾病中的QPL。这项工作的最接近的预期成果是开发一个可用的
食管-Qs,并收集患者激活随时间、药物
食管-Qs和标准之间的依从性、健康相关生活质量和GERD症状严重程度
在乎这项职业发展奖的试点数据将成为R 01资助的临床试验的基础,
在大量不同的人群中严格测试食管-Qs的疗效。
项目成果
期刊论文数量(0)
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