Behavioral Exercise Training to Reduce Cardiovascular Disease Risk in Men Undergoing Androgen Deprivation Therapy
行为运动训练可降低接受雄激素剥夺治疗的男性心血管疾病风险
基本信息
- 批准号:10740615
- 负责人:
- 金额:$ 12.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-25 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationActivities of Daily LivingAddressAdoptionAerobic ExerciseAgeBehavior TherapyBehavioralBody CompositionBuffersCancer CenterCancer PatientCancer SurvivorCardiacCardiac OutputCardiopulmonaryCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemClinicClinical TrialsCommunitiesConduct Clinical TrialsDataDevelopment PlansDiagnosisDropoutEducationEducational InterventionEffectivenessEnvironmentEventExerciseExercise TestFatigueFatty acid glycerol estersFunctional disorderFutureGeographyGoalsGuidelinesHealthHealth educationHeart failureHomeImaging TechniquesImpairmentIndividualInterventionInterviewIntramuscularLearning ModuleLeftMagnetic ResonanceMaintenanceMalignant NeoplasmsMalignant neoplasm of prostateMeasuresMedical centerMentored Research Scientist Development AwardMentorsMetabolicMetabolic syndromeMethodologyMethodsMorbidity - disease rateMuscleMusculoskeletalMusculoskeletal SystemMyocardial dysfunctionObesityOutcomeOxygenParticipantPatientsPeripheralPhysical FunctionPhysical activityPopulationProstate Cancer therapyQualifyingRaceRandomizedResearchResearch DesignResearch PersonnelResearch Project GrantsSamplingSkeletal MuscleStructureSurveysSymptomsTestingTrainingTraining ProgramsTreatment Side EffectsUnited States Department of Veterans AffairsVenousVentricularVirginiaWalkingWorkagedandrogen deprivation therapyarmcardiac magnetic resonance imagingcardiovascular disorder riskcardiovascular healthcardiovascular risk factorcareercareer developmentcomparison controlcoronary fibrosisdesigndisorder riskeffective interventionevidence baseexercise capacityexercise interventionexercise intoleranceexercise prescriptionexercise programexercise trainingexperiencefuture implementationhealth care availabilityhealth related quality of lifeheart functionhigh riskimprovedinsightintervention effectintervention refinementintraperitoneallean body massmalemenmortalitymuscle formnovelolder menoutcome predictionpreservationprogramsprostate cancer riskrecruitremote deliveryresistance exerciseskillsstrength trainingtherapy designtreatment effectvigorous intensity
项目摘要
1 PROJECT SUMMARY
2 A primary goal of this K01 proposal is to equip the candidate, Dr. Alexander Lucas, with the expertise to become
3 an independent investigator who is able to utilize state-of-the-art imaging techniques to evaluate subclinical
4 outcomes that predict future cardiovascular (CV) events in cancer patients, and that respond to behavioral
5 adaptations (i.e., exercise). Prostate cancer (PC) patients undergoing androgen deprivation therapy (ADT)
6 experience deleterious changes in CV risk factors (body composition, exercise intolerance, metabolic
7 dysfunction). Exercise training interventions are an effective non-pharmacological approach for managing these
8 negative effects of treatment. Furthermore, the use of non-invasive methods to determine CV and
9 musculoskeletal contributors to exercise capacity can inform the design of more precise exercise prescriptions
10 to address specific functional deficits in men initiating ADT. However, while supervised exercise training is
11 effective, many men lack access to such programs and establishing whether home-based behavioral exercise
12 programs can effectively improve exercise capacity (peak VO2) is important. Dr. Lucas’s preliminary data from
13 PC patients and other populations of cancer survivors support the feasibility and potential of exercise training to
14 limit treatment side effects. The proposed research project will provide critical data important for determining
15 whether exercise training leads to improvements in aerobic fitness (peak VO2), and whether central and/or
16 peripheral factors and components of body composition are key determinants of peak VO2 among men
17 undergoing treatment with ADT. Our primary hypothesis is that a combined aerobic and resistance training
18 intervention will improve peak VO2 by maintaining cardiovascular function, enhancing oxygen extraction at the
19 muscle, maintaining lean body mass, and reducing accumulation of fat mass. We propose a 2-arm, randomized
20 controlled trial to test a 12-week home-based and remotely delivered exercise intervention among
21 60 men undergoing ADT for intermediate to high-risk PC (Aim 1). We will use highly sensitive, non-
22 invasive cardiac magnetic resonance (CMR) imaging techniques with cardiopulmonary exercise testing
23 (CPET) to test effects of the intervention. We will also determine the relative contribution of central and peripheral
24 components of peak VO2 and their association with body composition (Aim 2). Surveys and qualitative semi-
25 structured interviews will be conducted with men who complete or dropout of the intervention to assess
26 intervention acceptability and to refine both content and delivery of a future intervention to be tested in a larger
27 RCT. This work focuses on optimizing cardiovascular health in men diagnosed with prostate cancer – a growing
28 population. The proposed K01 will provide essential training for the candidate, who will work closely with an
29 expert mentoring team with regard to study design and execution and the Career Development Plan. A specific
30 goal of training is to also gain advanced skills in design and conduct of clinical trials thus supporting the
31 implementation of future programs aiming to improve health outcomes in diverse communities.
1项目总结
项目成果
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Alexander Russell Lucas的其他文献
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