PrEParados: A Multi-Level Social Network Model to Increase PrEP Enrollment by Latino MSM Self-Identified as Gay, Bisexual

PrEParados：一种多层次社交网络模型，可提高自认是同性恋、双性恋的拉丁裔 MSM 的 PrEP 注册率

• 批准号: 10738838
• 负责人: Mariano Juan Kanamori Nishimura
• 金额: $ 6.61万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10738838
• 关键词: AIDS prevention; Address; Adherence; Alcohol consumption; Area; Bisexual; Characteristics; Clinic; Communication; County; Development; Diphosphates; Disclosure; Drug usage; Ego; Eligibility Determination; Emotional Bonds; Enrollment; Ensure; Epidemic; Ethnic Population; Frequencies; Friends; Friendships; Future; Gays; General Population; Geography; HIV; HIV risk; Health; Hearing; Incidence; Intervention; Knowledge; Latino; Latino Population; Learning; Measures; Mediation; Modeling; Motivation; Network-based; Outcome; Participant; Perception; Persons; Pharmaceutical Preparations; Population; Prevention Measures; Prevention strategy; Random Allocation; Research Personnel; Respondent; Safe Sex; Sample Size; Sampling; Services; Sexual Partners; Social Network; Structure; Study of Latinos; Subgroup; System; Tenofovir; Testing; Universities; Unmarried person; Work; cohesion; community organizations; male; men; men who have sex with men; metropolitan; network models; novel strategies; pre-exposure prophylaxis; pressure; programs; racial population; recruit; self organization; sex; sexual encounter; social; social organization; structural determinants; uptake

PROJECT SUMMARY PrEParados is a three-year developmental R01 study that will determine how social networks impact PrEP uptake and adherence among Latino men who have sex with men (LMSM), both those who self-identify as gay, and the unstudied group of LMSM who self-identify as bisexual/straight. This study will be implemented in Miami-Dade County (Miami), the epicenter of the HIV epidemic in the US. Among racial/ethnic groups in Miami, LMSM have the highest HIV incidence. Despite PrEP being the most effective HIV prevention measure currently available, few eligible LMSM in Miami are enrolled in a PrEP program (only 6% in 2018). Our preliminary study (N=130) suggests that social network structures may be contributing to LMSM’s low PrEP use. In that study of LMSM self-identified as gay, we discovered a large proportion of sexual encounters involved bisexual/straight LMSM. Self-identified bisexual/straight LMSM are a bridge between MSM—in whom the HIV epidemic is concentrated—and the general population in Miami. Before developing interventions, we need to implement this R01, which studies a larger sample to identify network configurations and dynamics impacting HIV risk among LMSM by their sexual self-identification (gay or bisexual/straight). To inform future interventions, our study will examine how social network structural factors suppress or promote access, encouragement, uptake, and adherence to PrEP. These findings will allow better deployment of accurate information and interventions, resulting in increased PrEP initiation and adherence amongst LMSM. PrEParados will study three social networks: 1) Friendship Networks—to identify social network mechanisms that promote PrEP use among LMSM friends in Miami. 2) Sexual Networks—to distinguish homophily and dyadic characteristics and dynamics associated with PrEP communication between sexual partners. 3) Venue Networks—to determine affiliations with geographic and online venues that could increase PrEP knowledge. Our established partnerships with Latinos Salud, Miami-Dade County Health Department PrEP Clinic, and the University of Miami’s Mobile PrEP Clinic and Rapid Access Wellness Clinic will provide access to 8,000+ LMSM, including 1,500+ PrEP users and 500+ who self-identify as bisexual/straight. This R01 study will provide new information that will allow PrEP interventions to include social network components and be tailored based on LMSM’s sexual self-identification. These new interventions could then serve as models for PrEP programs targeting males from other hard to reach populations.

项目概要 PrEParados 是一项为期三年的 R01 发展研究，将确定社交网络如何影响 PrEP 与男性发生性关系的拉丁裔男性 (LMSM) 的接受度和依从性，他们都自认为是 同性恋，以及未经研究的自称为双性恋/异性恋的 LMSM 群体。这项研究将在 迈阿密戴德县（迈阿密）是美国艾滋病毒流行的中心。在种族/族裔群体中 迈阿密、LMSM 的艾滋病毒发病率最高。尽管 PrEP 是最有效的艾滋病毒预防措施 目前，迈阿密很少有符合资格的 LMSM 参加 PrEP 计划（2018 年仅为 6%）。我们的 初步研究 (N=130) 表明社交网络结构可能导致 LMSM 的低 PrEP 使用。在对自我认定为同性恋的 LMSM 的研究中，我们发现很大比例的性接触 涉及双性恋/异性恋 LMSM。自我认定的双性恋/异性恋 LMSM 是 MSM 之间的一座桥梁——在他们中 艾滋病毒流行集中在迈阿密的一般人群。在制定干预措施之前，我们 需要实现这个 R01，它研究更大的样本来识别网络配置和动态 通过性别自我认同（同性恋或双性恋/异性恋）影响 LMSM 的艾滋病毒风险。告知未来 干预措施，我们的研究将研究社交网络结构因素如何抑制或促进访问， 鼓励、采用和坚持 PrEP。这些发现将有助于更好地部署准确的 信息和干预措施，从而提高 LMSM 中 PrEP 的启动率和坚持率。 PrEParados 将研究三种社交网络：1）友谊网络——识别社交网络机制 促进迈阿密 LMSM 朋友中 PrEP 的使用。 2) 性网络——区分同质性和同质性 与性伴侣之间的 PrEP 沟通相关的二元特征和动态。 3）场地 网络——确定与可以增加 PrEP 知识的地理和在线场所的联系。 我们与 Latinos Salud、迈阿密戴德县卫生局 PrEP 诊所以及 迈阿密大学的移动 PrEP 诊所和快速访问健康诊所将为 8,000 多名患者提供服务 LMSM，包括 1,500 多名 PrEP 用户和 500 多名自我认定为双性恋/异性恋的人。这项 R01 研究将 提供新的信息，使 PrEP 干预措施能够纳入社交网络组成部分并成为可能 根据LMSM的性别自我认同量身定制。这些新的干预措施可以作为模型 PrEP 计划针对其他难以接触人群的男性。