Precision Monitoring: Understanding Momentary Affect, Glucose, and Self-care Behaviors in Adolescents and Young Adults with type 1 diabetes
精确监测:了解患有 1 型糖尿病的青少年和年轻人的瞬时情绪、血糖和自我保健行为
基本信息
- 批准号:10746032
- 负责人:
- 金额:$ 19.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AdolescentAdolescent and Young AdultAffectAreaBehaviorBehavior TherapyBehavioralBehavioral SciencesBlood GlucoseCaringClinicalComplementContinuous Glucose MonitorControl GroupsCoupledDataData CollectionDevelopment PlansDiabetes MellitusDistressDoctor of PhilosophyEcological momentary assessmentEmotionalEncapsulatedEvaluationFeedbackFingersFutureGlucoseGlycosylated hemoglobin AGoalsInsulin-Dependent Diabetes MellitusInterventionInterviewInvestigationLongevityMentorsMethodsModalityModernizationMonitorOutcomeParticipantPatternPersonsProgram DevelopmentProtocols documentationQualitative ResearchRandomizedRandomized, Controlled TrialsRegulationResearchResearch PersonnelRiskSamplingSelf CareSeriesSocial EnvironmentStandardizationStatistical MethodsStructureSurveysTechnologyTestingTimeVacuumVisualacceptability and feasibilityagedblood glucose regulationcareercareer developmentcatalystcontextual factorsdashboarddiabetes distressdiabetes self-managementemotional distressexperiencegroup interventionhuman centered designimprovedimproved outcomeinnovationintervention programmeetingsmulti-component interventionmultidisciplinarynovelpeerpilot testpost interventionprecision medicineprogramspsychosocialresearch studysatisfactionskillssocialtooltrendusabilityvulnerable adolescentwillingness
项目摘要
PROJECT SUMMARY/ABSTRACT
Adolescents and Young Adults (AYA) with type 1 diabetes (T1D) have the highest hemoglobin A1c values of
all across the lifespan. Continuous Glucose Monitoring (CGM) is a modern approach to glucose assessment
that provides in-the-moment information about glucose levels to help optimize time-in-range ([TIR] 70-180
mg/dL). Retrospective review of ambulatory glucose patterns is an essential component for improving diabetes
self-care. However, many CGM users become overwhelmed by the voluminous CGM data and rarely review or
download their CGM. Furthermore, interpretation of CGM data should not occur in a vacuum, rather one
should consider contextual factors that impact self-care in order to improve glycemic regulation. Thus, to
maximize the clinical value of CGM in AYA with T1D, a novel, ecologically grounded approach is needed to
contextualize CGM data with information on the intra- and inter-personal context in which glucose regulation
occurs. It is timely to pair ecological momentary assessment (EMA) with CGM to develop an intervention
program to improve self-care, glycemia, and psychosocial outcomes. We will use rigorous methods to capture
dynamic relationships between in-the-moment ratings of emotional and social experiences (using EMA) and
CGM-recorded glucose values, which will be collectively displayed on a dashboard, encapsulating the
emotional and social context of ambulatory glucose (psychosocial ambulatory glucose [PAG]). Tracking
and reviewing of PAG patterns, along with ongoing structured support, within a multicomponent intervention,
will help AYA with T1D to better interpret and behaviorally respond to out-of-range glucose values, and may
serve as a catalyst to improve A1c, TIR, and self-care, as well as reduce diabetes distress. Amit Shapira, PhD,
proposes a series of studies with an overarching goal of developing, iteratively refining, and testing a PAG
intervention in AYA with T1D. The proposed 3 specific aims are: 1) to identify salient components of a PAG
dashboard using EMA that will coordinate the display of emotional and social context coupled with CGM
recorded data to enhance self-care of AYA with T1D above target A1c values using mixed methods; 2) to
adapt and build upon the dashboard for use in a behavioral intervention through expert feedback and guidance
from pertinent stakeholders; and 3) to examine if a pilot RCT of a refined PAG behavioral intervention will be
acceptable, feasible, and satisfactory to participants and have potential to improve diabetes and psychosocial
outcomes compared with PAG-alone. Results from these studies will inform a fully powered RCT for a future
R01 application. Dr. Shapira’s career objective is to become an independent diabetes behavioral researcher
focused on optimizing self-care, including use of CGM and other technologies, to improve outcomes for people
with T1D. The 5-year, mentored career development program will provide her with necessary skills in diabetes
care (e.g., diabetes technologies), advanced statistical methods, and usability and qualitative research to
launch her independence in diabetes behavioral investigation.
项目总结/摘要
患有1型糖尿病(T1 D)的青少年和年轻人(AYA)的血红蛋白A1 c值最高,
在整个生命周期中。动态血糖监测(CGM)是一种现代血糖评估方法
提供关于葡萄糖水平的即时信息,以帮助优化范围内时间([TIR] 70-180
毫克/分升)。回顾性回顾动态血糖模式是改善糖尿病的重要组成部分
自我照顾然而,许多CGM用户被大量的CGM数据弄得不知所措,并且很少回顾或
下载CGM此外,CGM数据的解释不应在真空中进行,而应在
应该考虑影响自我护理的背景因素,以改善血糖调节。从而
为了最大限度地发挥CGM在患有T1 D的AYA患者中的临床价值,需要一种新的、基于生态学的方法,
将CGM数据与关于葡萄糖调节的个人内和个人间背景的信息结合起来,
发生。将生态瞬时评估(EMA)与CGM相结合以制定干预措施是及时的
计划,以改善自我护理,康复和心理社会的结果。我们会用严格的方法
情绪和社会体验的即时评级之间的动态关系(使用EMA),
CGM记录的葡萄糖值,这些值将集中显示在仪表板上,
动态血糖的情绪和社会背景(心理社会动态血糖[PAG])。跟踪
在多成分干预中审查PAG模式,沿着持续的结构化支持,
将帮助患有T1 D的AYA更好地解释和行为响应超出范围的葡萄糖值,
作为一种催化剂,以改善A1 c,TIR和自我护理,以及减少糖尿病困扰。Amit Shapira博士,
提出了一系列的研究,其总体目标是开发、迭代改进和测试PAG
T1 D患者的AYA干预。建议的3个具体目标是:1)确定方案咨询组的主要组成部分
使用EMA的仪表板,将协调与CGM相结合的情感和社会背景的显示
使用混合方法记录数据,以增强T1 D高于目标A1 c值的AYA的自我护理; 2)
通过专家反馈和指导,调整和构建仪表板,用于行为干预
从相关的利益相关者;和3)检查是否有一个试点随机对照试验的一个完善的PAG行为干预将
可接受的,可行的,令人满意的参与者,并有可能改善糖尿病和心理社会
与单独使用PAG相比的结果。这些研究的结果将为未来的全面RCT提供信息
R 01应用程序。Shapira博士的职业目标是成为一名独立的糖尿病行为研究人员
专注于优化自我护理,包括使用CGM和其他技术,以改善人们的结果
关于T1 D为期5年的职业发展计划将为她提供必要的糖尿病技能
护理(例如,糖尿病技术),先进的统计方法,以及可用性和定性研究,
开展糖尿病行为独立调查。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Amit Shapira其他文献
Amit Shapira的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa
COVID-19 大流行期间健康社会决定因素的变化对青少年和年轻人心理健康的影响:南非 Asenze 队列的纵向研究
- 批准号:
10755168 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
A Priority Setting Partnership to Establish a Patient, Caregiver, and Clinician-identified Research Agenda for Adolescent and Young Adult Cancer in Canada
建立优先合作伙伴关系,以建立患者、护理人员和临床医生确定的加拿大青少年和年轻人癌症研究议程
- 批准号:
480840 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Miscellaneous Programs
Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise
青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
- 批准号:
10678157 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
不同种族青少年和年轻成年癌症幸存者的生育经历:一项基于人群的研究
- 批准号:
10744412 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Treatment development for refractory leukemia using childhood/adolescent, and young adult leukemia biobank
利用儿童/青少年和青年白血病生物库开发难治性白血病的治疗方法
- 批准号:
23K07305 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular design of Two-Way Player CAR-T cells to overcome disease/antigen heterogeneity of childhood, adolescent, and young adult cancers
双向 CAR-T 细胞的分子设计,以克服儿童、青少年和年轻成人癌症的疾病/抗原异质性
- 批准号:
23H02874 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
- 批准号:
10650648 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Developing and Testing a Culturally Tailored Mobile Health and Social MediaPhysical Activity Intervention Among Adolescent and Young Adult ChildhoodCancer Survivors
开发和测试针对青少年和青年儿童癌症幸存者的文化定制移动健康和社交媒体体育活动干预
- 批准号:
10736526 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别:
Pilot Project 1: Creating Bridges to Reproductive Health Care for Rural Adolescent and Young Adult Cancer Survivors
试点项目 1:为农村青少年和青年癌症幸存者搭建生殖保健桥梁
- 批准号:
10762146 - 财政年份:2023
- 资助金额:
$ 19.19万 - 项目类别: