UAB-UCSD O'Brien Center for Acute Kidney Injury Research

UAB-UCSD 奥布莱恩急性肾损伤研究中心

• 批准号: 10746567
• 负责人: ANUPAM AGARWAL
• 金额: $ 88.37万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746567
• 关键词: Acceleration; Acute Renal Failure with Renal Papillary Necrosis; Address; Alabama; Biomedical Research; California; Center Core Grants; Chronic Kidney Failure; Clinical; Clinical Research; Collaborations; Collection; Communities; Core Facility; Data; Development; Ecosystem; Electronic Health Record; Ensure; Environment; Extramural Activities; Fostering; Functional disorder; Funding; Health; Healthcare; Hospitalization; Hospitals; Imagination; Infrastructure; Institution; Investigation; Kidney; Kidney Diseases; Learning; Length of Stay; Machine Learning; Methods; Mission; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Paper; Patients; Prevention; Publications; Quality Control; Reproducibility; Research; Research Peer Review; Research Personnel; Resource Development; Resource Sharing; Resources; Rodent Model; Services; Technology; Testing; Training Programs; Translational Research; Universities; digital; experience; improved; in vivo imaging; innovation; member; metabolomics; mortality; pre-clinical; pre-clinical research; quality assurance; summer student; tool

Overall - Project Summary Kidney diseases in general and acute kidney injury (AKI) in particular impose substantial morbidity and mortality that remain unabated despite concerted efforts in recent decades to reduce both. The overall mission of the UAB-UCSD O’Brien Center for AKI Research is to improve the health of patients by fostering research specifically targeted to the prevention and treatment of AKI and its complications. To achieve this mission, our two institution-based Center crosses institutional boundaries and research fields, harnessing the momentum and ingenuity of ongoing pre-clinical and clinical research in each of our institutions and nationally. In this application to become a National Resource Center (NRC) in the O’Brien Kidney Consortium, our theme- based Center proposes to share and combine resources, methods, innovations, and other expertise with the other NRCs, under the guidance of the Steering Committee, National Coordinating Center, and NIDDK, to attract new scientific expertise into the field and coordinate and prioritize resource development and innovative services that are most essential to the Consortium. The following aims are proposed: (1) Integrate our O’Brien Center into the Consortium to accelerate the pace of AKI-related research through the support of shared Core facilities and expertise while ensuring quality assurance/quality control, rigor, and reproducibility for the Core services; (2) Foster meaningful interactions among investigators in the Consortium; (3) Through the NCC and the Consortium, share the Center’s intellectual resources and infrastructure to expand the diversity of investigators in AKI-related research, with an emphasis on early-stage investigators; (4) Utilize our Resource Development Core to respond to the evolving needs of investigators through promotion of innovative lines of investigation in AKI-related research; (5) Develop tomorrow’s thought leaders through our Summer Student Training Program; and (6) Leverage our substantial institutional commitments to propel the development of AKI-related research within the Consortium. The proposed Biomedical Research Cores (a Clinical Core and a Pre-clinical Core) and Resource Development Core will integrate existing intellectual and technological resources to provide the Consortium a set of services/resources for innovative investigation in AKI-related research. Our Clinical Core will uniquely build upon established networks and infrastructure in clinical AKI research, including a large biospecimen collection, and through the use of a collaborative digital workspace, enhance these resources and make them readily available to the Consortium. Simultaneously, our Pre-Clinical Core will uniquely provide the breadth of expertise, experimental tools, and resources to help investigators overcome barriers to the utilization of relevant rodent models and advance understanding of the pathophysiology of AKI. To advance both realms, our Resource Development Core will provide a dynamic platform to develop, test, and refine innovations, including new analytical approaches in metabolomics and functional in vivo imaging and tools for federated machine learning using big electronic health record data.

总体 - 项目摘要 肾脏疾病一般和急性肾脏损伤（AKI）尤其引发了大量的发病率和 近几十年来，死亡率仍然是尚未减弱的一致努力，以减少两者。整体任务 UAB-UCSD O'Brien AKI研究中心是通过促进研究来改善患者的健康状况 专门针对预防和治疗AKI及其并发症。为了实现这一任务， 我们的两个基于机构的中心跨越机构边界和研究领域，利用 我们每个机构和全国范围内正在进行的临床前和临床研究的动力和创造力。 在此申请中成为奥布莱恩肾脏财团的国家资源中心（NRC），我们的主题 - 基于共享和结合资源，方法，创新和其他专业知识的中心建议 在指导委员会，国家协调中心和NIDDK的指导下，其他NRCS 吸引新的科学专业知识进入该领域，协调和优先考虑资源开发和优先级 对财团最重要的创新服务。提出了以下目的：（1）整合 我们的奥布莱恩中心进入财团，通过支持 共享核心设施和专业知识，同时确保质量保证/质量控制，严格和可重复性 用于核心服务； （2）促进财团研究人员之间有意义的相互作用； （3）通过 NCC和财团，共享该中心的智力资源和基础设施，以扩展 研究人员在与AKI相关的研究中的多样性，重点是早期研究人员； （4）利用 我们的资源开发核心通过促进调查人员的需求做出响应 与AKI相关研究的创新投资线； （5）通过我们的明天的思想领袖 夏季学生培训计划； （6）利用我们实质性的机构承诺来推动 在财团内开发与AKI相关的研究。提出的生物医学研究核心（a 临床核心以及临床前的核心）和资源开发核心将整合现有的知识分子和 为财团提供一组服务/资源以创新投资的技术资源 与AKI相关的研究。我们的临床核心将在既定的网络和基础设施中唯一建立 临床AKI研究，包括大型的生物循环收集，并通过使用协作数字 工作空间，增强这些资源，并使财团容易获得。同时地， 我们的临床前核心将唯一提供专业知识，实验工具和资源的广度，以帮助 研究人员克服了利用相关啮齿动物模型的障碍，并提高了对 AKI的病理生理学。为了促进这两个领域，我们的资源开发核心将提供动态 开发，测试和完善创新的平台，包括代谢组学和 使用大型电子健康记录数据，用于联合机器学习的体内成像和工具。