Prenatal exposure to phthalates and associations with gestational weight gain and fetal growth trajectories.

产前接触邻苯二甲酸盐以及与妊娠体重增加和胎儿生长轨迹的关系。

• 批准号: 10746946
• 负责人: Shabnaz Siddiq
• 金额: $ 4.77万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746946
• 关键词: Asian; Biological Process; Biometry; Birth Weight; Black race; Body Weight; Chemicals; Classification; Complex Mixtures; Data; Development; Disparity; Education; Endocrine; Endocrine Disruptors; Ensure; Environment; Environmental Exposure; Epidemiology; Epigenetic Process; Equation; Ethnic Origin; Ethnic Population; Exposure to; Failure; Fetal Development; Fetal Growth; General Population; Genetic; Goals; Gonadal Steroid Hormones; Growth; Health; Hispanic; Hormonal; Immunity; Individual; Intervention; Kilogram; Knowledge; Life Cycle Stages; Literature; Longevity; Maternal and Child Health; Measures; Metabolism; Methodology; Methods; Mission; Modeling; Modification; Mothers; National Institute of Environmental Health Sciences; Nested Case-Control Study; Not Hispanic or Latino; Nulliparity; Outcome; Oxidative Stress; Participant; Pattern; Placenta; Placentation; Plastics; Policies; Population Heterogeneity; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Pregnant Women; Process; Productivity; Proxy; Race; Regulation; Reproduction; Research; Research Personnel; Research Proposals; Risk; Socioeconomic Factors; Specific qualifier value; Statistical Methods; Sum; Testing; Time; Training; United States; Universities; Woman; Work; advanced analytics; analytical method; career; cohort; critical period; environmental agent; environmental chemical; ethnic disparity; fetal; flexibility; gestational weight gain; glucose metabolism; healthy pregnancy; innovation; insulin sensitivity; lipid metabolism; maternal obesity; maternal outcome; maternal weight; obesity in children; personal care products; phthalates; pregnant; prenatal; prenatal exposure; racial disparity; racial diversity; racial population; sex; skills; theories; therapy design; urinary

PROJECT SUMMARY/ABSTRACT Widespread exposure to ubiquitous endocrine disrupting chemicals, such as phthalates, during pregnancy, a sensitive period in the life course for both mother and baby, is of global concern. Phthalates and their metabolites (PMs) are associated with increased oxidative stress, hormonal disturbances and epigenetic changes that may interfere with maternal gestational weight gain (GWG) and fetal growth patterns. Maternal GWG and fetal growth rates are important as they influence both short and long-term health outcomes of the mother and baby. Further, pregnancy related racial and ethnic disparities in pregnancy outcomes have persisted over time and environmental exposures may contribute to these. Non-Hispanic Black, Hispanic and Asian women have higher concentrations of PMs likely due to the use of specific personal care products. Although several studies have evaluated PM’s effect on birthweight (the end point of fetal growth) or on periods of GWG, few have considered associations between PMs and fetal growth and GWG rates and those that have are subject to methodological limitations. In addition, there is scarcity of evidence regarding associations between mixtures of PMs and adverse health outcomes. Using data from a nested case control study in a racially diverse population (Nulliparous Mothers To Be (nuMoM2b)), and specifically among healthy controls, we will explore associations between PMs and GWG and fetal growth trajectories using sophisticated statistical methods (i.e., growth mixture models, generalized estimating equations and weighted quantile sum regression) which account for multiple measures of both exposures and outcomes, and account for PM mixtures. We propose the following aims: 1) to examine associations between prenatal exposure to PMs (and their mixtures), measured in each pregnancy trimester and a) GWG and b) estimated fetal growth trajectories among 960 healthy pregnant women across the United States; 2) to evaluate modification by race/ethnicity and fetal-sex between PMs and GWG and fetal growth. This will be the first study to evaluate the effect of a ubiquitous environmental exposure on GWG and fetal growth trajectories. Findings from the proposed study are important to identify critical windows of gestation when maternal GWG and fetal growth may be more be more sensitive to insults from PMs. Importantly, this will aid the design of interventions to reduce phthalate exposure levels, inform policies to regulate phthalate concentrations in products, and educate and target women at greatest risk of exposure. Execution of these specific aims will advance NIEHS’s mission to understand the impact of a ubiquitous environmental exposure, phthalates, on salient maternal fetal outcomes. The proposed training plan will be delivered within Columbia University, one of the world’s preeminent research universities, providing skills in environmental exposures including mixtures analysis, maternal child health and advanced analytic methods that will, with the support of an excellent sponsor team, will ensure successful completion of the study aims and prepare me to a career as an independent productive researcher.

项目总结/摘要 怀孕期间广泛接触普遍存在的内分泌干扰化学品，如邻苯二甲酸盐， 这是母亲和婴儿生命历程中的敏感期，受到全球关注。邻苯二甲酸酯及其 代谢物（PMs）与氧化应激增加、激素紊乱和表观遗传有关。 可能干扰母体妊娠期体重增加（GWG）和胎儿生长模式的变化。产妇 GWG和胎儿生长率是重要的，因为它们会影响胎儿的短期和长期健康结果。 母亲和婴儿。此外，妊娠结局中与妊娠相关的种族和民族差异， 长期持续存在，环境暴露可能是原因之一。非西班牙裔黑人、西班牙裔和 亚洲女性有较高的PMs浓度可能是由于使用特定的个人护理产品。 尽管有几项研究评估了PM对出生体重（胎儿生长的终点）或月经周期的影响， 在GWG中，很少有人考虑PM与胎儿生长和GWG率之间的关系， 这些问题受到方法上的限制。此外，缺乏有关关联的证据， PMs的混合物和不良健康结果之间的关系。使用嵌套病例对照研究的数据， 种族多样性人群（未生育母亲（Nulliparous Mothers To Be，nuMoM 2b）），特别是健康对照人群， 我们将使用复杂的统计学方法来探讨PM和GWG与胎儿生长轨迹之间的关系， 方法（即，增长混合模型、广义估计方程和加权分位数和回归） 这说明了暴露和结果的多种测量，并说明了PM混合物。我们 提出以下目标：1）检查产前暴露于PM（及其 混合物），在每个妊娠三个月测量，和a）GWG和B）估计的胎儿生长轨迹 在美国960名健康孕妇中; 2）评估人种/种族的改变， PM和GWG之间的胎儿性别和胎儿生长。这将是第一项评估 普遍存在的环境暴露对GWG和胎儿生长轨迹的影响。拟议研究的结果 当母体GWG和胎儿生长可能更重要时， 对首相的侮辱更敏感重要的是，这将有助于设计减少邻苯二甲酸酯的干预措施 暴露水平，为监管产品中邻苯二甲酸酯浓度的政策提供信息， 女性暴露风险最大。这些具体目标的执行将推进NIEHS的使命， 了解普遍存在的环境暴露邻苯二甲酸盐对显著的母婴结局的影响。 拟议的培训计划将在哥伦比亚大学内实施，哥伦比亚大学是世界上最杰出的大学之一。 研究型大学，提供环境暴露技能，包括混合物分析、孕产妇和儿童 健康和先进的分析方法，在优秀的赞助商团队的支持下，将确保 成功地完成研究的目的，并准备我的职业生涯作为一个独立的生产研究。