2023 Cell Growth and Proliferation Gordon Research Conference and Seminar

摘要 这项建议是请求NCI支持戈登研究会议(GRC)的部分支持 《细胞生长与增殖：发育与癌症中的细胞周期与增殖》会议将于 聚集150-200名研究生、博士后研究员、教职员工、初级和高级教职员工、实验室负责人 行业和政府讨论他们最新的未发表发现。会议的重点将是 关于正常细胞增殖控制的机制，正常生长所需的许多细胞周期变化， 以及癌症和其他增殖性疾病中细胞周期异常扰动的种类。该计划 格式是邀请的演讲者与从 2023年春季，重点是来自多个学科、职业阶段、 人口统计和地理背景。主席和副主席特别致力于创建一个 多元化和包容性的会议，反映了细胞周期控制和基本癌细胞的广度 生物学研究，展示了该领域初级和高级成员的贡献；44% 已确认的受邀演讲者为女性，所有讨论者均为女性。正式研究会议的主题 计划包括一次以发育和癌症中的蛋白质降解为重点的开幕式，以及其他 会议包括1)细胞周期机制和细胞分裂，2)增殖和基因组稳定性，3) 细胞周期进展和静止的机制，4)驱动细胞周期，4)靶向肿瘤中的CDKs， 5)发育和癌症中的信号通路，6)基因组完整性和免疫，以及7)系统生物学 和基因组学。此外，还将举行四场宣传性会议，并为非正式会议提供充足的自由时间 网络。我们还将使用资金部分支持附属的戈登研究研讨会(GRS)。这个 GRS是一项为期1.5天的活动，紧接着由博士后和学生组织的GRC之前 展示他们的工作，并参与职业发展。这两项活动都将在西部雪山度假村举行 2023年7月9日至14日在佛蒙特州多佛市举行，GRC是一个在广度上相对独特的主要会议，因为 它汇集了来自学术和行业环境的专注于基础生物学和翻译生物学的研究人员。

SUMMARY This proposal is a request for support from the NCI for partial support of the Gordon Research Conference (GRC) “Cell Growth and Proliferation: Cell Cycle and Proliferation in Development and Cancer.” The conference will gather 150-200 graduate students, postdoctoral fellows, staff scientists, junior and senior faculty, lab leaders in industry and government for discussions of their most recent unpublished discoveries. The Conference will focus on mechanisms of normal cell proliferation control, the many cell cycle variations required for normal growth, and the variety of abnormal cell cycle perturbations in cancer and other proliferative diseases. The program format is an approximately equal mix of invited speakers with speakers selected from abstract submitted in the spring of 2023 with an emphasis on broad representation of speakers from multiple disciplines, career stages, demographic and geographic backgrounds. The Chair and Vice Chair are specifically committed to creating a diverse and inclusive conference that reflects the breadth of cell cycle control and fundamental cancer cell biology research and that showcases the contributions of both junior and senior members of the field; 44% of the confirmed invited speakers are women and all discussants are women. Topics of formal research sessions planned include an opening session focused on Protein Degradation in Development and Cancer and additional sessions including 1) Cell Cycle Machinery and Cell Division, 2) Proliferation and Genome Stability, 3) Mechanisms of Cell Cycle Progression and Quiescence, 4) Driving the Cell Cycle, 4) Targeting CDKs in Cancer, 5) Signaling Pathways in Development and Cancer, 6) Genome Integrity and Immunity, and 7) System biology and Genomics. In addition, there will be four poster sessions and ample unstructured time for informal networking. We will also use funding to partially support the affiliated Gordon Research Seminar (GRS). The GRS is a 1.5day event that immediately precedes the GRC organized by and for postdocs and students to present their work and engage in career development. Both events will be held at Mount Snow Resort, West Dover, Vermont from July 9-14, 2023, and the GRC is a major conference relatively unique in its breadth because it brings together researchers focused on basic and translational biology from academic and industry settings.