Neural Correlates of Auditory, Visual, and Audiovisual Motion Perception in Macaque Extrastriate Cortex

猕猴纹状体外皮层听觉、视觉和视听运动知觉的神经相关性

• 批准号: 10751148
• 负责人: Adriana Schoenhaut
• 金额: $ 3.3万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10751148
• 关键词: Address; Algorithms; Anatomy; Anesthesia procedures; Animals; Area; Attention deficit hyperactivity disorder; Auditory; Automobile Driving; Behavior; Behavioral; Behavioral Model; Behavioral Paradigm; Binding; Blindness; Brain; Clinical; Complex; Cues; Darkness; Diagnostic; Discrimination; Effectiveness; Environment; Event; Functional disorder; Future; Human; Individual; Individual Differences; Knowledge; Link; Macaca; Maps; Medial; Modality; Modeling; Motion; Motion Perception; Perception; Performance; Psychophysics; Pulvinar structure; Recording of previous events; Role; Schizophrenia; Sensory; Signal Transduction; Source; Specific qualifier value; Stimulus; Symptoms; Task Performances; Technology; Therapeutic; Training; Virtual and Augmented reality; Visual; Visual Motion; Visual Pathways; Work; area MST; autism spectrum disorder; behavioral response; experimental study; extrastriate visual cortex; goal oriented behavior; hearing impairment; human imaging; imaging study; improved; insight; loss of function; multisensory; neglect; neural; neural correlate; nonhuman primate; response; sample fixation; segregation; sensory cortex; sensory integration; sensory stimulus; sensory system; sound; success

PROJECT SUMMARY Our world is highly multisensory, and we acquire information about it via a number of distinct sensory systems. Typically, objects or events are specified by more than a single sense, and the integration of this multisensory information confers powerful and adaptive perceptual and behavioral advantages such as faster and more accurate responses. These advantages become pivotal when navigating complex environments where motion is ubiquitous, as is the case in the real world. However, multisensory processing also presents a computational challenge for the brain: to carry it out efficiently, the brain needs to not only decide which pieces of sensory information belong to the same event (and thus should be integrated or bound), but also which information needs to be segregated. Although great strides have been made in recent years to further our understanding of multisensory perception and its neural correlates, there are still significant gaps in our knowledge with regards to processing more ecologically-valid stimuli, such as those containing motion. One of these gaps revolves around how motion information is transformed in the presence of modulatory, cross-modal input as it makes its way through successive stages of the cortical processing hierarchy, and how these transformations map on to behavior/perception. The experiments outlined in the current proposal begin to address this issue using behavioral paradigms that we have developed in which macaques signal the direction of an auditory, visual, or audiovisual motion stimulus. During performance of the task, we will record neural activity in two cortical domains reflecting successive levels in the processing hierarchy: the medial temporal (MT) and medial superior temporal (MST) areas. The first aim will examine how modality and motion strength within audiovisual stimuli impact discrimination behavior and contribute towards causal inference. The second aim seeks to characterize responses to auditory, visual, and audiovisual motion information in these areas with the overarching hypothesis that as motion information ascends from MT to MST, there will be an increase in the role of modulatory auditory input, reflective of a gradual shift from encoding low-level stimulus features such as signal strength toward the encoding of features relevant to goal-oriented behavior such as stimulus direction and task demands. Collectively, the work will shed great light on the mechanistic underpinnings of multisensory perception in nodes critical to motion processing. Additionally, success in these experiments would challenge how we think about the modularity of the sensory cortical processing hierarchy. Such knowledge is of increasing importance given the growing recognition of altered multisensory function in those with neurodevelopmental conditions and/or sensory function loss, as well as the value of brain-informed algorithms for naturalistic virtual and augmented reality technology.

项目总结