Diversity Center for Genome Research at Meharry

梅哈里基因组研究多样性中心

• 批准号: 10749781
• 负责人: Anil Shanker
• 金额: $ 86.62万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749781
• 关键词: Academic support; Acceleration; Accreditation; Address; African ancestry; Basic Science; Biological Markers; Biological Products; Blood; Cells; Chronic Disease; Clinical; Clinical Sciences; Collaborations; Collection; Communities; Competence; Complement; Computational Science; Dementia; Disadvantaged minority; Disease; Effectiveness; Elements; Ensure; Equity; Faculty; Financial Support; Fostering; Genetic; Genetic Counseling; Genetic Databases; Genetic study; Genome; Genomics; Healthcare; Historically Black Colleges and Universities; Immunophenotyping; Inequity; Inflammatory; Infrastructure; Institution; International; Investments; Letters; Lung; Malignant Neoplasms; Mentors; Mentorship; Minority Groups; Mitochondria; Monitor; Pathogenesis; Pathway interactions; Persons; Precision Health; Process; Research; Research Activity; Research Personnel; Sarcoidosis; Scholarship; Scientist; Skin; Southeastern United States; Students; Teacher Professional Development; Tennessee; Training; Training Programs; Translational Research; Tuberculosis; Universities; Variant; Vision; Visit; Workforce Development; career; career development; cohort; community building; community engagement; community organizations; exome; genome sciences; health disparity; human genomics; inattention; loss of function; lymph nodes; medical schools; migration; minority investigator; minority student; phenome; prognostic indicator; programs; recruit; repository; response; social; synergism; volunteer

Project Summary Meharry Medical College is committed to bridging the gaps for underrepresented, disadvantaged minority (URM) groups by establishing a Diversity Center for Genome Research (DCGR). The Diversity Center will narrow inequitable representation gaps for URM by realizing our vision to promote African ancestry genomic research through infrastructure building and the formation of basic, clinical, and computational science research teams that are inclusive, interdisciplinary, and community-engaged. Also, the proposed DCGR will facilitate a sustainable partnership among HBCU including MMC, Fisk University, and Tennessee State University in Nashville. The establishment of DCGR will complement MMC’s ongoing genomics capacity-building initiatives. Meharry DCGR research theme will focus on studying the genetic basis of chronic diseases prevalent in AA. Project 1 (Borza) will study the loss-of-function variant genome-phenome association in inflammatory diseases, such as dementia, cancer, tuberculosis, and sarcoidosis (also termed: Besnier-Boeck-Schauman) that typically presents in lungs (skin or lymph nodes) as abnormal collections of inflammatory cells. Project 2 (Ivanova) aims to correlate the genetics of inflammatory/mitochondrial responses to immunophenotypes to identify prognostic indicators of health disparities. Project 3 (Singh) aims to address barriers to recruitment and build a blood repository of AA people to evaluate disease biomarkers associated with health disparities. The DCGR efforts will be spearheaded by three Cores. The Administrative Core will manage the Center's administrative, fiscal, and scientific aspects, including accreditation of new graduate programs, oversight of career enhancement activities for students, trainees, and faculty, and fostering synergy with other ongoing genomic training and career development activities. The Genomic Workforce Development Core will initiate new academic activities, including new graduate programs in genomics and genetic counseling training to educate and train minority students and researchers in genomic sciences for diversifying the URM genomics research workforce. The Community Engagement Core will enhance sustainable partnerships with community-based organizations and the AA community to address their concerns and promote their participation in the Center’s research activities. The Cores will finalize, implement, and oversee a management plan that stimulates, coordinates, integrates, and monitors activities and functions across all elements of the Cores addressing: Aim 1. Transform the organizational infrastructure and processes supporting academic excellence in African ancestry genome research at MMC; Aim 2. Promote scholarship within the research collaborations and mentorship networks to enrich the quality of genome research and provide a nexus for scientific community building among basic, clinical, and computational science stakeholders with social and academic integration; Aim 3. Maximize the effectiveness of a faculty cohort to advance genome research competencies and attainment of career milestones by fostering faculty development and making MMC a magnet that attracts other URM genomics scholars.

项目摘要 梅哈里医学院致力于为代表不足、处境不利的少数群体弥合差距 (URM)通过建立基因组研究多样性中心(DCGR)。多样性中心将缩小 通过实现我们促进非洲血统基因组研究的愿景，URM的不公平代表差距 通过基础设施建设和基础、临床和计算科学研究团队的组建 具有包容性、跨学科和社区参与性。此外，拟议的区政府资源中心将有助 年，HBCU包括MMC、Fisk大学和田纳西州立大学之间的可持续合作伙伴关系 纳什维尔。DCGR的建立将补充MMC正在进行的基因组学能力建设倡议。 Meharry DCGR的研究主题将集中在研究再生障碍性贫血中流行的慢性疾病的遗传基础。 项目1(Borza)将研究炎症性疾病中功能丧失的变异基因组-表观组关联， 如痴呆症、癌症、肺结核和结节病(也称为：Besnier-Boeck-Schauman)，通常 肺部(皮肤或淋巴结节)出现异常炎性细胞聚集。项目2(伊万诺瓦)旨在 将炎症/线粒体反应的遗传学与免疫表型相关联以确定预后 健康差距的指标。项目3(Singh)旨在解决招募障碍和建立血液 AA人群的资料库，以评估与健康差异相关的疾病生物标志物。DCGR的努力将 由三个核心带头。行政核心将管理中心的行政、财务和 科学方面，包括认证新的研究生方案、监督职业发展活动 面向学生、实习生和教职员工，并促进与其他正在进行的基因组培训和职业生涯的协同 发展活动。基因组劳动力发展核心将发起新的学术活动， 包括新的基因组学研究生课程和遗传咨询培训，以教育和培训少数民族 基因组科学方面的学生和研究人员，以使URM基因组研究人员多样化。这个 社区参与核心将加强与社区组织的可持续伙伴关系 AA社区解决他们的关切，并促进他们参与中心的研究活动。 核心将最终确定、实施和监督一个管理计划，该计划旨在激励、协调、整合和 监控核心寻址的所有元素的活动和功能：目标1.转变 支持非洲血统基因组方面学术卓越的组织基础设施和程序 在MMC进行研究；目标2。在研究合作和导师网络中促进学术研究，以 丰富基因组研究的质量，为基础、临床、 与社会和学术整合的计算科学利益相关者；目标3.最大限度地提高有效性 提高基因组研究能力和实现职业里程碑的教职员工队伍 教师发展和使MMC成为吸引其他URM基因组学学者的磁石。