Diversity Center for Genome Research at Meharry

梅哈里基因组研究多样性中心

• 批准号: 10749781
• 负责人: Anil Shanker
• 金额: $ 86.62万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749781
• 关键词: Academic support; Acceleration; Accreditation; Address; African ancestry; Basic Science; Biological Markers; Biological Products; Blood; Cells; Chronic Disease; Clinical; Clinical Sciences; Collaborations; Collection; Communities; Competence; Complement; Computational Science; Dementia; Disadvantaged minority; Disease; Effectiveness; Elements; Ensure; Equity; Faculty; Financial Support; Fostering; Genetic; Genetic Counseling; Genetic Databases; Genetic study; Genome; Genomics; Healthcare; Historically Black Colleges and Universities; Immunophenotyping; Inequity; Inflammatory; Infrastructure; Institution; International; Investments; Letters; Lung; Malignant Neoplasms; Mentors; Mentorship; Minority Groups; Mitochondria; Monitor; Pathogenesis; Pathway interactions; Persons; Precision Health; Process; Research; Research Activity; Research Personnel; Sarcoidosis; Scholarship; Scientist; Skin; Southeastern United States; Students; Teacher Professional Development; Tennessee; Training; Training Programs; Translational Research; Tuberculosis; Universities; Variant; Vision; Visit; Workforce Development; career; career development; cohort; community building; community engagement; community organizations; exome; genome sciences; health disparity; human genomics; inattention; loss of function; lymph nodes; medical schools; migration; minority investigator; minority student; phenome; prognostic indicator; programs; recruit; repository; response; social; synergism; volunteer

Project Summary Meharry Medical College is committed to bridging the gaps for underrepresented, disadvantaged minority (URM) groups by establishing a Diversity Center for Genome Research (DCGR). The Diversity Center will narrow inequitable representation gaps for URM by realizing our vision to promote African ancestry genomic research through infrastructure building and the formation of basic, clinical, and computational science research teams that are inclusive, interdisciplinary, and community-engaged. Also, the proposed DCGR will facilitate a sustainable partnership among HBCU including MMC, Fisk University, and Tennessee State University in Nashville. The establishment of DCGR will complement MMC’s ongoing genomics capacity-building initiatives. Meharry DCGR research theme will focus on studying the genetic basis of chronic diseases prevalent in AA. Project 1 (Borza) will study the loss-of-function variant genome-phenome association in inflammatory diseases, such as dementia, cancer, tuberculosis, and sarcoidosis (also termed: Besnier-Boeck-Schauman) that typically presents in lungs (skin or lymph nodes) as abnormal collections of inflammatory cells. Project 2 (Ivanova) aims to correlate the genetics of inflammatory/mitochondrial responses to immunophenotypes to identify prognostic indicators of health disparities. Project 3 (Singh) aims to address barriers to recruitment and build a blood repository of AA people to evaluate disease biomarkers associated with health disparities. The DCGR efforts will be spearheaded by three Cores. The Administrative Core will manage the Center's administrative, fiscal, and scientific aspects, including accreditation of new graduate programs, oversight of career enhancement activities for students, trainees, and faculty, and fostering synergy with other ongoing genomic training and career development activities. The Genomic Workforce Development Core will initiate new academic activities, including new graduate programs in genomics and genetic counseling training to educate and train minority students and researchers in genomic sciences for diversifying the URM genomics research workforce. The Community Engagement Core will enhance sustainable partnerships with community-based organizations and the AA community to address their concerns and promote their participation in the Center’s research activities. The Cores will finalize, implement, and oversee a management plan that stimulates, coordinates, integrates, and monitors activities and functions across all elements of the Cores addressing: Aim 1. Transform the organizational infrastructure and processes supporting academic excellence in African ancestry genome research at MMC; Aim 2. Promote scholarship within the research collaborations and mentorship networks to enrich the quality of genome research and provide a nexus for scientific community building among basic, clinical, and computational science stakeholders with social and academic integration; Aim 3. Maximize the effectiveness of a faculty cohort to advance genome research competencies and attainment of career milestones by fostering faculty development and making MMC a magnet that attracts other URM genomics scholars.

项目概要 梅哈里医学院致力于缩小代表性不足的弱势少数群体的差距 (URM) 集团通过建立基因组研究多样性中心 (DCGR)。多元化中心将缩小 通过实现促进非洲血统基因组研究的愿景，消除 URM 的不平等代表性差距 通过基础设施建设和基础、临床和计算科学研究团队的组建 具有包容性、跨学科和社区参与。此外，拟议的 DCGR 将促进 HBCU 之间的可持续伙伴关系，包括 MMC、菲斯克大学和田纳西州立大学 纳什维尔。 DCGR 的建立将补充 MMC 正在进行的基因组学能力建设计划。 Meharry DCGR 研究主题将集中于研究 AA 中流行的慢性疾病的遗传基础。 项目 1 (Borza) 将研究炎症性疾病中功能丧失变异基因组-表型组的关联， 例如痴呆症、癌症、结核病和结节病（也称为：Besnier-Boeck-Schauman），通常 出现在肺部（皮肤或淋巴结）中，表现为异常的炎症细胞聚集。项目 2 (Ivanova) 的目标 将炎症/线粒体反应的遗传学与免疫表型相关联，以确定预后 健康差异指标。项目 3（Singh）旨在解决招募障碍并建立血液 AA 人员存储库，用于评估与健康差异相关的疾病生物标志物。 DCGR 的努力将 由三个核心带头。行政核心将管理中心的行政、财政和 科学方面，包括新研究生课程的认证、职业提升活动的监督 为学生、实习生和教师提供帮助，并促进与其他正在进行的基因组培训和职业的协同作用 发展活动。基因组劳动力发展核心将启动新的学术活动， 包括基因组学和遗传咨询培训方面的新研究生课程，以教育和培训少数群体 基因组科学领域的学生和研究人员，使 URM 基因组学研究队伍多样化。这 社区参与核心将加强与社区组织的可持续伙伴关系 AA 社区解决他们的担忧并促进他们参与中心的研究活动。 核心人员将最终确定、实施和监督一项管理计划，该计划旨在激励、协调、整合和管理 监控核心所有要素的活动和职能，解决： 目标 1. 转变 支持非洲血统基因组学术卓越的组织基础设施和流程 MMC 的研究；目标 2. 在研究合作和导师网络中促进奖学金， 丰富基因组研究的质量，并为基础、临床、 以及具有社会和学术一体化的计算科学利益相关者；目标 3. 最大化效率 一支教师队伍，通过培养 师资队伍的发展，使 MMC 成为吸引其他 URM 基因组学学者的磁石。