Investigation of Sex Differences in Physical Activity and its Relationships with Stress After Myocardial Infarction

心肌梗死后体力活动的性别差异及其与应激的关系调查

• 批准号: 10751366
• 负责人: Kara Suvada
• 金额: $ 4.77万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10751366
• 关键词: Adult; Affect; Age Years; Ambulatory Monitoring; Ancillary Study; Area; Assessment tool; Atherosclerosis; Automobile Driving; Autonomic nervous system; Behavioral; Blood Pressure; Cardiovascular Diseases; Cardiovascular Manifestation; Cardiovascular system; Cause of Death; Cessation of life; Collaborations; Data; Decision Making; Disparity; Elderly; Enrollment; Ensure; Event; Fellowship; Frequencies; Functional disorder; Funding; Future; Goals; Guidelines; Health Technology; Heart Diseases; Hormonal; Hour; Individual; Inflammation; Investigation; Link; Lipoproteins; Measures; Mental Health; Mentors; Metabolic; Monitor; Motivation; Myocardial Infarction; Myocardial Ischemia; National Heart, Lung, and Blood Institute; Nervous System Physiology; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Physical activity; Physiological; Physiology; Plasma; Play; Policies; Policy Maker; Population; Prevention; Prevention program; Prognosis; Psyche structure; Psychological Stress; Public Health; Reporting; Research; Research Project Grants; Risk Factors; Risk Reduction; Role; Sex Differences; Stress; Training; United States; United States Dept. of Health and Human Services; Woman; Work; Wrist; actigraphy; aged; behavioral study; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular risk factor; career; clinical practice; cohort; design; early onset; emotional symptom; experience; heart rate variability; high risk; indexing; insight; insulin sensitivity; mHealth; men; modifiable risk; older women; outcome disparities; personalized intervention; physical inactivity; physical symptom; post intervention; primary outcome; protective factors; sex; stress reduction; therapy design; young man; young woman

PROJECT ABSTRACT/SUMMARY Although heart disease is the number one cause of death among women, prevention efforts in women have lagged. Additionally, in most studies to date, research on heart disease has focused on older women, but there is a growing burden of myocardial infarction among women under 60 years of age. Recent studies point to stress as playing a more important role in the manifestation of cardiovascular disease risk factors in younger women compared to younger men. Women experience increased emotional and physical symptoms as a result of stress. Psychological stress and autonomic physiological (i.e., heart rate variability) are associated with physical inactivity. Physical inactivity is a major risk factor for cardiovascular diseases and death. Therefore, more research is needed to investigate the role of physical inactivity as a unique risk factor for cardiovascular diseases amongst young women. We will leverage data from the NHLBI-funded study: Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis (MIMS3) (2 R01 HL109413) in order to investigate the role of stress and physical activity in a group of post-MI women and men. In AIM 1, we will compare physical activity levels between young post-MI women and men. In AIM 2, we will investigate whether daily reports of psychological stress are temporally associated with physical activity levels in post-MI individuals and examine for interaction by sex. And in AIM 3, we will examine whether autonomic physiology (i.e., heart rate variability) is temporally associated with physical activity levels in post-MI individuals and examine for interaction by sex. We hypothesize that there will be differences in physical activity between women and men who are post-MI. We also hypothesize that there will be a bi-directional, temporal relationship between both physiological and autonomic physiology and physical activity. This research project will be important in generating the impetus for future studies regarding risk factors for cardiovascular diseases in young, post-MI individuals, especially with regards to stress reduction as a lever for increasing physical activity. We hope that this research aids in decisions made by public health practitioners, clinicians, and policy-makers in the design of interventions for post-MI populations that could help narrow the gap in and reduce the risk factors for negative cardiovascular outcomes by sex.

项目摘要/摘要 尽管心脏病是妇女死亡的头号原因，但妇女的预防工作 落后了。此外，到目前为止，在大多数研究中，关于心脏病的研究都集中在老年女性身上，但 在60岁以下的女性中，心肌梗死是一个日益沉重的负担。最近的研究指出 应激在年轻人心血管疾病危险因素的表现中发挥更重要的作用 女性与年轻男性相比。女性的情绪和身体症状随着年龄的增长而增加 这是压力的结果。心理应激和自主神经生理(即心率变异性)相关。 缺乏体力活动。缺乏运动是心血管疾病和死亡的主要风险因素。 因此，需要更多的研究来调查缺乏运动作为一种独特的危险因素对高血压的作用 年轻女性中的心血管疾病。我们将利用NHLBI资助的研究数据：Mind 心肌梗死后的应激和心肌缺血：性别差异、机制和预后(MIMS3)(2 R01 HL109413)，以调查压力和体力活动在一组心肌梗死后女性和男性中的作用。 在目标1中，我们将比较心肌梗死后年轻女性和男性的体力活动水平。在AIM 2中，我们将 调查每日报告的心理压力是否与体力活动水平暂时相关 在心肌梗塞后的个体中，检查性别的相互作用。在AIM 3中，我们将检查自主神经 生理学(即心率变异性)与心肌梗死后个体的体力活动水平在时间上相关。 并检查性行为的相互作用。我们假设两国在体力活动方面会有所不同 MI后的女性和男性。我们还假设，将会有一种双向的、暂时的关系 生理和自主神经生理学和体力活动之间的关系。这项研究项目将是 对推动未来关于中国心血管疾病危险因素的研究具有重要意义 年轻人，心肌梗塞后，特别是在减轻压力作为增加体力活动的杠杆方面。 我们希望这项研究有助于公共卫生从业者、临床医生和政策制定者的决策。 在为心肌梗死后人群设计干预措施时，可以帮助缩小差距和降低风险 按性别划分的心血管负性结局的因素。