Interoception as a Novel Risk Factor for Suicidal Thoughts and Behaviors

内感受作为自杀想法和行为的新危险因素

• 批准号: 10750168
• 负责人: Azure Reid-Russell
• 金额: $ 3.39万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10750168
• 关键词: Adolescence; Adolescent; Adult; Area; Attention; Cause of Death; Clinical; Data Collection; Development; Ecological momentary assessment; Exhibits; Exposure to; Feeling suicidal; Goals; Hospitalization; Hospitals; Interoception; Intervention; Language; Learning; Link; Longevity; Measurement; Mediating; Mediator; Meta-Analysis; Methods; Modeling; Nature; Pathway interactions; Perception; Prevention; Process; Psychopathology; Psychophysiology; Public Health; Recording of previous events; Research; Risk; Risk Factors; Sampling; Severities; Statistical Methods; Statistical Models; Suicide; Suicide prevention; Surveys; Testing; Time; Training; United States; Work; aged; bodily sensation; directed attention; experience; high risk; high-risk adolescents; improved; innovation; insight; negative affect; novel; pediatric trauma; programs; psychologic; skills; statistics; suicidal adolescent; suicidal behavior; suicidal risk; suicide rate; traumatized children; years of life lost

Project Summary Suicide is a leading cause of death worldwide and the second leading cause of death for adolescents in the US. Despite advances in understanding of suicidal thoughts and behaviors and their treatment, the suicide rate has not decreased. One possible factor limiting progress in this area has been a lack of focus on understanding (and targeting) developmental mechanisms that may give rise to suicidal thoughts and behaviors. Interoception, the perception of internal bodily states, holds promise as a novel factor that may increase risk for suicide. Suicidal thoughts and behaviors center around inflicting harm to the body, yet surprisingly little work has tested whether and how disrupted interoceptive processes may contribute to risk for suicide. Given the centrality of the body in suicidal thoughts and behaviors and the unique interoceptive learning and processing that may occur during adolescence, altered interoceptive processing represents a novel risk factor that may advance understanding of suicidal thoughts and behaviors among adolescents. This proposal tests the associations between interoceptive processes and the occurrence of suicidal thoughts and behaviors. Eighty adolescents with and without suicidal thoughts and behaviors will undergo assessments of suicidal thoughts and behaviors, psychophysiological measurement of interoceptive processes, exposure to childhood trauma, and ecological momentary assessments of suicidal thoughts and behaviors and appraisals of body sensations. Aim 1 of this proposal is to test the association between perceptual interoceptive processes (i.e., interoceptive accuracy, sensitivity, and attention) and suicidal thoughts and behaviors. Aim 2 of this proposal is to test the association between appraisals and descriptions of body sensations and suicidal thoughts and behaviors. Aim 3 of this proposal is to test whether interoceptive processes are a potential mediator of the associations between childhood trauma and suicidal thoughts and behaviors. The proposed study’s greatest potential impacts are to use innovative strategies to study a novel potential risk factor for suicidal thoughts and behaviors, identify putative pathways that have clear translational value, and to potentially identify novel targets for intervention to treat suicidal thoughts and behaviors in adolescents.

项目摘要 自杀是世界范围内青少年死亡的主要原因，也是全世界青少年死亡的第二大原因。 我们。尽管对自杀想法和行为及其治疗的理解取得了进展，但自杀率 并没有减少。限制这一领域进展的一个可能因素是缺乏对 了解(和针对)可能导致自杀念头和 行为。内感是对身体内部状态的感知，作为一种新的因素，它可能 增加自杀风险。自杀的想法和行为以对身体造成伤害为中心，但 令人惊讶的是，很少有研究测试受扰的内感过程是否以及如何可能导致高血压风险 自杀。鉴于身体在自杀想法和行为中的中心地位以及独特的内感 青春期可能发生的学习和加工，改变的内感加工代表着一种 新的危险因素可能会促进青少年对自杀想法和行为的理解。这 Proposal测试了内感过程和自杀念头的发生之间的联系，以及 行为。80名有和没有自杀想法和行为的青少年将接受 自杀想法和行为，心理生理学测量的相互感觉过程，暴露于 童年创伤，自杀念头和行为的生态瞬间评估和评估 身体的感觉。这项建议的目的1是测试知觉间知觉之间的联系 过程(即感觉上的准确性、敏感度和注意力)以及自杀的想法和行为。目标2 这项建议是为了测试身体感觉的评价和描述与自杀之间的联系。 思想和行为。这项建议的目标3是测试内感过程是否具有潜在的 童年创伤与自杀念头和行为之间关系的调停者。建议数 这项研究最大的潜在影响是使用创新的策略来研究一种新的潜在风险因素 自杀想法和行为，确定具有明确翻译价值的假定路径，并 有可能确定干预青少年自杀念头和行为的新靶点。