Resilient HIV Implementation Science with Sexual and Gender Minority Youths using Evidence (RISE) Clinical Research Center

使用证据对性和性别少数青少年进行弹性艾滋病毒实施科学 (RISE) 临床研究中心

• 批准号: 10749084
• 负责人: Sylvia Adebajo
• 金额: $ 125.29万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749084
• 关键词: AIDS prevention; Acceleration; Address; Affect; Africa; Africa South of the Sahara; African; Age; Baltimore; Behavioral; Case Management; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Centers for Population Health; Characteristics; Clinical Management; Clinical Research; Clinical effectiveness; Collaborations; Communities; Community Health; Consolidated Framework for Implementation Research; Continuity of Patient Care; Country; Cybersex; Data; Data Analyses; Development; Doctor of Medicine; Doctor of Philosophy; Epidemic; Equity; Goals; Guidelines; HIV; HIV Infections; HIV Seropositivity; Health; Health Services; Health education; Health system; High Prevalence; Human; Implementation readiness; Incidence; Interdisciplinary Study; International; Internet; Intervention; Kenya; Knowledge; Leadership; Malawi; Maryland; Morbidity - disease rate; Nigeria; Outcome; Penetration; Persons; Policies; Policy Making; Prevention; Prevention Research; Process; Randomized, Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Readiness; Recommendation; Research; Resources; Risk; Risk Reduction; Role; Scientist; Services; Sex Behavior; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Shapes; Site; Southern Africa; Strategic Planning; System; Testing; Translating; USAID; United States; Universities; Viral Load result; Vision; Work; Youth; Zambia; biosecurity; care systems; clinical implementation; community engagement; cost effectiveness; data management; data quality; design; digital health; effectiveness evaluation; effectiveness/implementation study; epidemic response; experience; follow-up; fortification; implementation science; implementation strategy; implementation/effectiveness; improved; international center; man; mortality; multidisciplinary; outreach; peer; pre-exposure prophylaxis; programs; provider adoption; resilience; seropositive; service delivery; service providers; sexual role; social; social stigma; transgender women; treatment as usual; trial design; uptake; virology; young men who have sex with men

PROJECT SUMMARY Sexual and gender minority (young men who have sex with men [YMSM] and young transgender women [YTW]) youths (ages 15-24 years) at risk of and living with HIV are poorly represented in international implementation science (IS) research. The overarching goal of Resilient HIV Implementation Science with SGM Youths using Evidence (RISE) Clinical Research Center is to make significant contributions to the development and conduct of IS studies to improve HIV prevention and care continuum (PHCC). A strategic planning process including a comprehensive review of our CRC's role in accelerating and maximizing the integration of digital health into practice, increasing the scientific capacity for IS research with SGM youths, translating findings to inform national and global guidelines on clinical management of SGM youths was conducted to inform this proposal. A vision statement encompassing four Themes – Equity in Partnerships for Access, Youth-tailored Intervention, Rigor IS Research, and Collaboration Capacity for Sustainability shapes our work. The RISE Clinical Research Center is a multidisciplinary research group composed of an administrative core at the University of Maryland Baltimore and five clinical research performing sites (CRPSs) that represent a network of implementing partners and community-based HIV service providers (CBSPs) in West, East, and Southern Africa: (1) Centre for Population Health Initiatives, Nigeria (CPHI); (2) Institute of Human Virology, Nigeria (IHVN); (3) Partners for Health & Development in Africa, Kenya (PHDA); (4) Centre for the Development of People (CEDEP); and (5) Center for International Health Education Biosecurity, Zambia (Ciheb Zambia). Together, we have over fifteen years of leadership experience in the design, implementation, and conduct of health service studies with SGM youths in SSA and the United States (US). Under the leadership of the multiple PIs, Man Charurat Ph.D, Lisa Hightow-Weidman M.D., Sylvia Adebajo, PhD, a youth and SGM service delivery and policy-making multidisciplinary investigative team together with representatives from AHISA in each country including Kate Muessig, Ph.D, – a behavioral scientist, Nadia Sam-Agudu M.D. – AHISA Nigeria, Kwango Agot Ph.D, M.P.H – AHISA Kenya, Nora Rosenberg, Ph.D. – AHISA Malawi, and Maurice Musheke, Ph.D. M.P.H – AHISA Zambia, we will participate in the adaptation and customization of a digital health platform and conduct its implementation to support PHCC among SGM youths. Centralized resources for regulatory compliance, data management, data quality, and data analysis across the CRPSs promote RISE CRC's efficiency and quality. Collaboration capacity with AHISA, health ministries, and youth advisory boards for community engagement, IS capacity development, and sustainability will promote RISE CRC's impact locally and globally.

项目总结