Resilient HIV Implementation Science with Sexual and Gender Minority Youths using Evidence (RISE) Clinical Research Center

使用证据对性和性别少数青少年进行弹性艾滋病毒实施科学 (RISE) 临床研究中心

• 批准号: 10749084
• 负责人: Sylvia Adebajo
• 金额: $ 125.29万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749084
• 关键词: AIDS prevention; Acceleration; Address; Affect; Africa; Africa South of the Sahara; African; Age; Baltimore; Behavioral; Case Management; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Centers for Population Health; Characteristics; Clinical Management; Clinical Research; Clinical effectiveness; Collaborations; Communities; Community Health; Consolidated Framework for Implementation Research; Continuity of Patient Care; Country; Cybersex; Data; Data Analyses; Development; Doctor of Medicine; Doctor of Philosophy; Epidemic; Equity; Goals; Guidelines; HIV; HIV Infections; HIV Seropositivity; Health; Health Services; Health education; Health system; High Prevalence; Human; Implementation readiness; Incidence; Interdisciplinary Study; International; Internet; Intervention; Kenya; Knowledge; Leadership; Malawi; Maryland; Morbidity - disease rate; Nigeria; Outcome; Penetration; Persons; Policies; Policy Making; Prevention; Prevention Research; Process; Randomized, Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Readiness; Recommendation; Research; Resources; Risk; Risk Reduction; Role; Scientist; Services; Sex Behavior; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Shapes; Site; Southern Africa; Strategic Planning; System; Testing; Translating; USAID; United States; Universities; Viral Load result; Vision; Work; Youth; Zambia; biosecurity; care systems; clinical implementation; community engagement; cost effectiveness; data management; data quality; design; digital health; effectiveness evaluation; effectiveness/implementation study; epidemic response; experience; follow-up; fortification; implementation science; implementation strategy; implementation/effectiveness; improved; international center; man; mortality; multidisciplinary; outreach; peer; pre-exposure prophylaxis; programs; provider adoption; resilience; seropositive; service delivery; service providers; sexual role; social; social stigma; transgender women; treatment as usual; trial design; uptake; virology; young men who have sex with men

PROJECT SUMMARY Sexual and gender minority (young men who have sex with men [YMSM] and young transgender women [YTW]) youths (ages 15-24 years) at risk of and living with HIV are poorly represented in international implementation science (IS) research. The overarching goal of Resilient HIV Implementation Science with SGM Youths using Evidence (RISE) Clinical Research Center is to make significant contributions to the development and conduct of IS studies to improve HIV prevention and care continuum (PHCC). A strategic planning process including a comprehensive review of our CRC's role in accelerating and maximizing the integration of digital health into practice, increasing the scientific capacity for IS research with SGM youths, translating findings to inform national and global guidelines on clinical management of SGM youths was conducted to inform this proposal. A vision statement encompassing four Themes – Equity in Partnerships for Access, Youth-tailored Intervention, Rigor IS Research, and Collaboration Capacity for Sustainability shapes our work. The RISE Clinical Research Center is a multidisciplinary research group composed of an administrative core at the University of Maryland Baltimore and five clinical research performing sites (CRPSs) that represent a network of implementing partners and community-based HIV service providers (CBSPs) in West, East, and Southern Africa: (1) Centre for Population Health Initiatives, Nigeria (CPHI); (2) Institute of Human Virology, Nigeria (IHVN); (3) Partners for Health & Development in Africa, Kenya (PHDA); (4) Centre for the Development of People (CEDEP); and (5) Center for International Health Education Biosecurity, Zambia (Ciheb Zambia). Together, we have over fifteen years of leadership experience in the design, implementation, and conduct of health service studies with SGM youths in SSA and the United States (US). Under the leadership of the multiple PIs, Man Charurat Ph.D, Lisa Hightow-Weidman M.D., Sylvia Adebajo, PhD, a youth and SGM service delivery and policy-making multidisciplinary investigative team together with representatives from AHISA in each country including Kate Muessig, Ph.D, – a behavioral scientist, Nadia Sam-Agudu M.D. – AHISA Nigeria, Kwango Agot Ph.D, M.P.H – AHISA Kenya, Nora Rosenberg, Ph.D. – AHISA Malawi, and Maurice Musheke, Ph.D. M.P.H – AHISA Zambia, we will participate in the adaptation and customization of a digital health platform and conduct its implementation to support PHCC among SGM youths. Centralized resources for regulatory compliance, data management, data quality, and data analysis across the CRPSs promote RISE CRC's efficiency and quality. Collaboration capacity with AHISA, health ministries, and youth advisory boards for community engagement, IS capacity development, and sustainability will promote RISE CRC's impact locally and globally.

项目概要 性少数和性别少数（男男性行为的年轻男性 [YMSM] 和年轻的变性女性 [YTW]）面临艾滋病毒感染风险和感染艾滋病毒的青少年（15-24 岁）在国际社会中的代表性很低 实施科学（IS）研究。弹性艾滋病毒实施科学的总体目标 SGM青少年循证（RISE）临床研究中心将为SGM青年循证医学研究做出重大贡献 开发和开展 IS 研究，以改善艾滋病毒预防和护理连续体 (PHCC)。战略性的 规划过程，包括全面审查我们的 CRC 在加速和最大化 将数字健康融入实践，提高SGM青年的IS研究科学能力， 将研究结果转化为 SGM 青少年临床管理的国家和全球指南 为告知本提案而进行。包含四个主题的愿景声明——伙伴关系中的公平 的获取、针对青年的干预、严谨的信息系统研究以及协作能力 可持续发展塑造了我们的工作。 RISE临床研究中心是一个多学科研究小组 由马里兰大学巴尔的摩分校的行政核心和五个临床研究组成 代表实施伙伴和社区艾滋病毒网络的执行站点 (CRPS) 西非、东非和南部非洲的服务提供商 (CBSP)：(1) 人口健康倡议中心， 尼日利亚（CPHI）； (2) 尼日利亚人类病毒学研究所（IHVN）； (3) 健康与发展合作伙伴 非洲，肯尼亚（哲学博士）； (4) 人类发展中心（CEDEP）； (5) 国际中心 赞比亚健康教育生物安全（Ciheb Zambia）。我们共同拥有超过十五年的领导地位 在SSA和SGM青少年中设计、实施和进行健康服务研究的经验 美国（US）。在多个 PI 的领导下，Man Charurat Ph.D、Lisa Hightow-Weidman M.D.、Sylvia Adebajo 博士、青年和 SGM 服务提供和政策制定多学科调查 团队与 AHISA 在每个国家的代表一起工作，其中包括 Kate Muessig 博士（行为学博士） 科学家，Nadia Sam-Agudu 医学博士 – AHISA 尼日利亚，Kwango Agot 博士，公共卫生硕士 – AHISA 肯尼亚，Nora 罗森伯格博士– AHISA Malawi 和 Maurice Musheke 博士M.P.H – AHISA 赞比亚，我们将参加 数字健康平台的调整和定制并进行实施以支持 SGM青年中的PHCC。用于法规遵从性、数据管理、数据质量的集中资源， 跨 CRPS 的数据分析提升了 RISE CRC 的效率和质量。协作能力 与 AHISA、卫生部和青年咨询委员会一起促进社区参与、IS 能力 发展和可持续性将提升 RISE CRC 在当地和全球的影响力。