Resilient HIV Implementation Science with Sexual and Gender Minority Youths using Evidence (RISE) Clinical Research Center

使用证据对性和性别少数青少年进行弹性艾滋病毒实施科学 (RISE) 临床研究中心

• 批准号: 10749084
• 负责人: Sylvia Adebajo
• 金额: $ 125.29万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749084
• 关键词: AIDS prevention; Acceleration; Address; Affect; Africa; Africa South of the Sahara; African; Age; Baltimore; Behavioral; Case Management; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Centers for Population Health; Characteristics; Clinical Management; Clinical Research; Clinical effectiveness; Collaborations; Communities; Community Health; Consolidated Framework for Implementation Research; Continuity of Patient Care; Country; Cybersex; Data; Data Analyses; Development; Doctor of Medicine; Doctor of Philosophy; Epidemic; Equity; Goals; Guidelines; HIV; HIV Infections; HIV Seropositivity; Health; Health Services; Health education; Health system; High Prevalence; Human; Implementation readiness; Incidence; Interdisciplinary Study; International; Internet; Intervention; Kenya; Knowledge; Leadership; Malawi; Maryland; Morbidity - disease rate; Nigeria; Outcome; Penetration; Persons; Policies; Policy Making; Prevention; Prevention Research; Process; Randomized, Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Readiness; Recommendation; Research; Resources; Risk; Risk Reduction; Role; Scientist; Services; Sex Behavior; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Shapes; Site; Southern Africa; Strategic Planning; System; Testing; Translating; USAID; United States; Universities; Viral Load result; Vision; Work; Youth; Zambia; biosecurity; care systems; clinical implementation; community engagement; cost effectiveness; data management; data quality; design; digital health; effectiveness evaluation; effectiveness/implementation study; epidemic response; experience; follow-up; fortification; implementation science; implementation strategy; implementation/effectiveness; improved; international center; man; mortality; multidisciplinary; outreach; peer; pre-exposure prophylaxis; programs; provider adoption; resilience; seropositive; service delivery; service providers; sexual role; social; social stigma; transgender women; treatment as usual; trial design; uptake; virology; young men who have sex with men

PROJECT SUMMARY Sexual and gender minority (young men who have sex with men [YMSM] and young transgender women [YTW]) youths (ages 15-24 years) at risk of and living with HIV are poorly represented in international implementation science (IS) research. The overarching goal of Resilient HIV Implementation Science with SGM Youths using Evidence (RISE) Clinical Research Center is to make significant contributions to the development and conduct of IS studies to improve HIV prevention and care continuum (PHCC). A strategic planning process including a comprehensive review of our CRC's role in accelerating and maximizing the integration of digital health into practice, increasing the scientific capacity for IS research with SGM youths, translating findings to inform national and global guidelines on clinical management of SGM youths was conducted to inform this proposal. A vision statement encompassing four Themes – Equity in Partnerships for Access, Youth-tailored Intervention, Rigor IS Research, and Collaboration Capacity for Sustainability shapes our work. The RISE Clinical Research Center is a multidisciplinary research group composed of an administrative core at the University of Maryland Baltimore and five clinical research performing sites (CRPSs) that represent a network of implementing partners and community-based HIV service providers (CBSPs) in West, East, and Southern Africa: (1) Centre for Population Health Initiatives, Nigeria (CPHI); (2) Institute of Human Virology, Nigeria (IHVN); (3) Partners for Health & Development in Africa, Kenya (PHDA); (4) Centre for the Development of People (CEDEP); and (5) Center for International Health Education Biosecurity, Zambia (Ciheb Zambia). Together, we have over fifteen years of leadership experience in the design, implementation, and conduct of health service studies with SGM youths in SSA and the United States (US). Under the leadership of the multiple PIs, Man Charurat Ph.D, Lisa Hightow-Weidman M.D., Sylvia Adebajo, PhD, a youth and SGM service delivery and policy-making multidisciplinary investigative team together with representatives from AHISA in each country including Kate Muessig, Ph.D, – a behavioral scientist, Nadia Sam-Agudu M.D. – AHISA Nigeria, Kwango Agot Ph.D, M.P.H – AHISA Kenya, Nora Rosenberg, Ph.D. – AHISA Malawi, and Maurice Musheke, Ph.D. M.P.H – AHISA Zambia, we will participate in the adaptation and customization of a digital health platform and conduct its implementation to support PHCC among SGM youths. Centralized resources for regulatory compliance, data management, data quality, and data analysis across the CRPSs promote RISE CRC's efficiency and quality. Collaboration capacity with AHISA, health ministries, and youth advisory boards for community engagement, IS capacity development, and sustainability will promote RISE CRC's impact locally and globally.

项目摘要 性和性别少数群体（与男性发生性关系的年轻男性[YMSM]和年轻变性女性 [YTW]）在国际上，有感染艾滋病毒风险和已感染艾滋病毒的青年（15-24岁）所占比例很低。 实施科学（IS）研究。艾滋病毒实施科学的总体目标是， SGM青少年循证医学（RISE）临床研究中心正在为 制定和开展信息系统研究，以改进艾滋病毒预防和护理连续体。战略 规划过程，包括全面审查我们的CRC在加速和最大限度地提高 将数字健康融入实践，提高SGM青年IS研究的科学能力， 将研究结果转化为关于SGM青少年临床管理的国家和全球指南， 为这一提议提供信息。一份包含四个主题的愿景声明-伙伴关系中的平等 获取，青年量身定制的干预，严谨的研究，和协作能力， 可持续性塑造了我们的工作。RISE临床研究中心是一个多学科研究小组 由马里兰州巴尔的摩大学的一个行政核心和五个临床研究组成 代表实施伙伴和社区艾滋病毒网络的执行地点（CRPS） 西非、东非和南部非洲的保健服务提供者：（1）人口保健倡议中心， 尼日利亚（CPHI）;（2）人类病毒学研究所，尼日利亚（IHVN）;（3）非洲健康与发展伙伴组织 非洲，肯尼亚（PHDA）;（4）人民发展中心（CEDEP）;（5）国际发展中心 卫生教育和生物安全，赞比亚（Ciheb Zambia）。我们共同拥有超过15年的领导经验 在设计，实施和开展卫生服务研究的经验，与SGM青年在SSA和 美国（US）。在多名PI的领导下，Man Charurat博士、丽莎海托-魏德曼 医学博士，西尔维娅Adebajo，博士，青年和SGM服务交付和决策多学科调查 团队与AHISA在每个国家的代表一起，包括Kate Muessig博士-一个行为 科学家Nadia Sam-Agudu医学博士- AHISA尼日利亚，Kwango Agot Ph.D，M. P. H- AHISA肯尼亚，诺拉 Rosenberg博士- AHISA Malawi和Maurice Musheke博士MPH- AHISA赞比亚，我们将参加 在数字健康平台的适应和定制，并进行其实施，以支持 SGM年轻人中的PHCC。集中资源，用于法规遵从性、数据管理、数据质量， 跨CRPS的数据分析提高了RISE CRC的效率和质量。协作能力 与AHISA、卫生部和青年咨询委员会合作，促进社区参与， 发展和可持续性将促进RISE CRC在当地和全球的影响。