Effects of parental history of suicidal behavior on middle/late childhood: Longitudinal assessment of early markers of suicide risk

父母自杀行为史对童年中后期的影响：自杀风险早期标记的纵向评估

• 批准号: 10750571
• 负责人: Arielle Hope Sheftall
• 金额: $ 42.69万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10750571
• 关键词: Adolescence; Adolescent; Age; Age of Onset; Arousal; Arousal and Regulatory Systems; Attention; Behavioral; Biological; Black race; Cause of Death; Child; Childhood; Development; Emergency department visit; Emotional; Enrollment; Family; Feeling suicidal; Female; Functional disorder; Future; Goals; Intervention; Interview; Knowledge; Learning; Measures; Mediating; Mediator; Mental Health; Methods; National Institute of Mental Health; Neurocognitive; Neurocognitive Deficit; Parents; Participant; Patient Self-Report; Population Heterogeneity; Populations at Risk; Positive Valence; Prevention; Prevention strategy; Primary Prevention; Public Health; Race; Recording of previous events; Regulation; Research; Research Domain Criteria; Research Priority; Rewards; Risk; Risk Factors; Role; Sampling; Social Processes; Strategic Planning; Suicide; Suicide attempt; System; Techniques; Testing; Visit; Youth; age group; age related; aged; black men; black women; cognitive control; cognitive system; cohort; computerized; early onset; emotion dysregulation; experience; externalizing behavior; high risk; high risk population; male; non-suicidal self injury; offspring; peer; prevent; racial disparity; racial population; recruit; sex; sex disparity; social communication; suicidal adolescent; suicidal behavior; suicidal risk; suicide rate; transmission process; trend

PROJECT SUMMARY/ABSTRACT Suicide is the fifth leading cause of death among U.S. children 5 to 12 years, yet limited research on childhood suicide and suicidal behavior (SB) exists. The National Institute of Mental Health (NIMH) has acknowledged this critical gap as a high research priority. A significant risk factor for the early onset of a first suicide attempt (SA) is a parental history of SB. Although the familial transmission of SB is well documented, research examining the specific mechanisms associated with familial risk is limited. Our ongoing NIMH-R21 study (Cohort 1) is investigating factors related to the familial risk of SB in children, 6-9 years, with (PH+; n=100) and without (PH-; n=100) a parental history of SA. This proposed R01 study will continue annual follow-ups for Cohort 1 and add an additional 300 newly enrolled families (Cohort 2; ages 9-11 years; 150 per PH group) for a total sample of 500 parent-child dyads. Youth will be followed for four years from mid/late-childhood through early/mid-adolescence. Using the Research Domain Criteria (RDoC) framework, we will examine the trajectories of neurocognitive function (NF), emotional reactivity/regulation (ERR), non-suicidal self-injury (NSSI), suicidal ideation (SI), and SA in PH+ and PH- youth along with contributions by sex and race. Study participants at first assessment include youth 7-12 years. At last assessment, youth ages will range from 10-15 years. Both groups, PH+ and PH-, will be balanced by sex and race. Two main research aims and one exploratory aim will be tested. Aim 1: Examine longitudinally how PH status is associated with trajectories of NF and ERR constructs measured during mid/late-childhood through early/mid-adolescence. Aim 2: Investigate the potential mediating role of NF and ERR constructs on the association between PH status and offspring NSSI, SI, and SA. Exploratory Aim: Test sex and race as potential moderators of ERR and NF trajectories, and on the association between PH status and offspring NSSI, SI, and SA. This proposal’s central hypotheses are that (1) PH+ status increases vulnerability for developmental trajectories characterized by NF deficits and emotional dysfunction/dysregulation; (2) these trajectories will mediate the association between PH status and youth NSSI, SI, and SA; and (3) these associations between trajectories and SB/NSSI will be moderated by both sex and race. The hypotheses are informed by preliminary findings from the ongoing NIMH- R21 study, where group differences were found for ERR, SB, and NF. The proposed R01 study aligns well with the NIMH 2020 Strategic Plan for Research with emphasis on Goal 2-investigating mental health trajectories and inclusion of diverse samples. Completing the proposed study will assist with the identification of specific mechanisms associated with the familial risk of SB, determine if sex and race moderate the associations between risks and youth SB, and provide direction for targeted prevention strategies for high-risk youth.

项目总结/文摘