Effects of parental history of suicidal behavior on middle/late childhood: Longitudinal assessment of early markers of suicide risk

父母自杀行为史对童年中后期的影响：自杀风险早期标记的纵向评估

• 批准号: 10366565
• 负责人: Arielle Hope Sheftall
• 金额: $ 45.88万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10366565
• 关键词: Adolescence; Adolescent; Age; Age of Onset; Arousal; Arousal and Regulatory Systems; Behavioral; Biological; Black race; Cause of Death; Child; Childhood; Development; Emergency department visit; Emotional; Enrollment; Family; Feeling suicidal; Female; Frustration; Functional disorder; Future; Goals; Intervention; Interview; Knowledge; Learning; Measures; Mediating; Mediator of activation protein; Mental Health; Methods; National Institute of Mental Health; Neurocognitive; Neurocognitive Deficit; Parents; Participant; Patient Self-Report; Population Heterogeneity; Positive Valence; Prevention; Prevention strategy; Primary Prevention; Public Health; Race; Recording of previous events; Regulation; Research; Research Domain Criteria; Research Priority; Rewards; Risk; Risk Factors; Role; Sampling; Social Processes; Strategic Planning; Suicide; Suicide attempt; System; Techniques; Testing; Visit; Youth; age group; age related; aged; attentional control; black men; black women; cognitive control; cognitive system; cohort; computerized; early onset; emotion dysregulation; experience; externalizing behavior; high risk; high risk population; male; non-suicidal self injury; offspring; peer; prevent; racial disparity; recruit; sex; sex disparity; social communication; suicidal adolescent; suicidal behavior; suicidal risk; suicide rate; transmission process; trend

PROJECT SUMMARY/ABSTRACT Suicide is the fifth leading cause of death among U.S. children 5 to 12 years, yet limited research on childhood suicide and suicidal behavior (SB) exists. The National Institute of Mental Health (NIMH) has acknowledged this critical gap as a high research priority. A significant risk factor for the early onset of a first suicide attempt (SA) is a parental history of SB. Although the familial transmission of SB is well documented, research examining the specific mechanisms associated with familial risk is limited. Our ongoing NIMH-R21 study (Cohort 1) is investigating factors related to the familial risk of SB in children, 6-9 years, with (PH+; n=100) and without (PH-; n=100) a parental history of SA. This proposed R01 study will continue annual follow-ups for Cohort 1 and add an additional 300 newly enrolled families (Cohort 2; ages 9-11 years; 150 per PH group) for a total sample of 500 parent-child dyads. Youth will be followed for four years from mid/late-childhood through early/mid-adolescence. Using the Research Domain Criteria (RDoC) framework, we will examine the trajectories of neurocognitive function (NF), emotional reactivity/regulation (ERR), non-suicidal self-injury (NSSI), suicidal ideation (SI), and SA in PH+ and PH- youth along with contributions by sex and race. Study participants at first assessment include youth 7-12 years. At last assessment, youth ages will range from 10-15 years. Both groups, PH+ and PH-, will be balanced by sex and race. Two main research aims and one exploratory aim will be tested. Aim 1: Examine longitudinally how PH status is associated with trajectories of NF and ERR constructs measured during mid/late-childhood through early/mid-adolescence. Aim 2: Investigate the potential mediating role of NF and ERR constructs on the association between PH status and offspring NSSI, SI, and SA. Exploratory Aim: Test sex and race as potential moderators of ERR and NF trajectories, and on the association between PH status and offspring NSSI, SI, and SA. This proposal’s central hypotheses are that (1) PH+ status increases vulnerability for developmental trajectories characterized by NF deficits and emotional dysfunction/dysregulation; (2) these trajectories will mediate the association between PH status and youth NSSI, SI, and SA; and (3) these associations between trajectories and SB/NSSI will be moderated by both sex and race. The hypotheses are informed by preliminary findings from the ongoing NIMH- R21 study, where group differences were found for ERR, SB, and NF. The proposed R01 study aligns well with the NIMH 2020 Strategic Plan for Research with emphasis on Goal 2-investigating mental health trajectories and inclusion of diverse samples. Completing the proposed study will assist with the identification of specific mechanisms associated with the familial risk of SB, determine if sex and race moderate the associations between risks and youth SB, and provide direction for targeted prevention strategies for high-risk youth.

项目摘要/摘要 自杀是美国5-12岁儿童的第五大死因，但对儿童的研究有限 自杀和自杀行为(SB)存在。美国国家精神卫生研究所(NIMH)承认 这一关键差距被视为高度优先的研究事项。导致首次自杀未遂提前发生的重要危险因素 (Sa)是某人的父母史。尽管SB的家族传播有很好的记录，但研究 研究与家族性风险相关的具体机制是有限的。我们正在进行的NIMH-R21研究 (队列1)正在调查与6-9岁儿童(PH+；n=100)的SB家庭风险相关的因素 无亲代SA病史(PH-；n=100)。这项拟议的R01研究将继续进行年度跟踪 队列1，并增加额外300个新登记的家庭(队列2；年龄9-11岁；每个PH组150个) 总共500个亲子二人组的样本。将对青少年进行为期四年的跟踪调查，从儿童时期中期/后期到 青春期早期/中期。使用研究领域标准(RDoC)框架，我们将检查 神经认知功能(NF)、情绪反应/调节(ERR)、非自杀性自我伤害的轨迹 PH+和PH-青年中的NSSI、自杀意念(SI)和SA以及性别和种族的贡献。学习 第一次评估的参与者包括7-12岁的青少年。根据最新评估，青少年年龄将从10岁到15岁不等。 好几年了。这两组人，PH+和PH-，都将按性别和种族进行平衡。两个主要研究目标和一个 将测试探索性目标。目标1：纵向检查PH状态与运动轨迹的关系 在儿童期中期/后期到青春期早期/中期测量的NF和ERR结构。目标2： 研究NF和ERR结构在PH状态和PH值之间关系中的潜在中介作用 后代NSSI、SI和SA。探索性目标：测试性别和种族作为ERR和NF的潜在调节因素 以及PH状态与后代NSSI、SI和SA之间的关联。这项提议的核心是 假说是(1)PH+状态增加了以NF为特征的发育轨迹的易感性 缺陷和情绪障碍/调节失调；(2)这些轨迹将在PH之间的联系中起中介作用 地位和青年NSSI、SI和SA；以及(3)轨迹与SB/NSSI之间的这些关联将是 受到性别和种族的影响。这些假设是由正在进行的NIMH的初步发现- R21研究，其中发现ERR、SB和NF的组差异。拟议的R01研究很好地符合 NIMH 2020研究战略计划，重点是目标2--调查心理健康轨迹 以及包含不同的样本。完成拟议的研究将有助于确定具体的 与SB家族风险相关的机制决定了性别和种族是否缓和了这种联系 风险与青年SB之间的关系，并为针对高危青年的有针对性的预防战略提供方向。