Establishing Readiness of Dental Professionals in Practice-Based Research and Inter-Professional Care

项目摘要 基于实践的研究（PBR）已证明将循证护理纳入临床的有效性 实践，提高研究结果的普遍性，并进行纵向研究，这是通过 传统的随机对照研究。医学领域的PBR网络（PBRN）始于1970年， 在推进医学研究成果和将研究证据转化为实践方面发挥了关键作用 以改善患者的治疗效果。国家牙科和颅面研究所（NIDCR） 2005年建立了牙科实践为基础的研究网络，它现在被认为是最大的 世界上最大的牙科PBRN。然而，PBR经验尚未成为牙科的一部分， 博士前/博士后课程。根据NIDCR，“让牙科学生参与研究”是至关重要的 活动，并将循证原则纳入牙科课程，以提高他们的批判性思维 评估新知识并将其融入实践的技能。在本申请中，印第安纳州大学（IU） 牙科学院（IUSD）研究人员具有基础科学，PBR，信息学和唾液 诊断学已经与印第安纳州临床和转化科学研究所（CTSI）建立了合作， IU医学院（IUSM），普渡大学药学院，Regenstrief研究所，Inc。和印第安纳州卫生部 信息交流促进牙科临床教师和学员的临床研究培训，并加强 学生、临床教师和研究人员之间的研究指导伙伴关系。我们将增进知识 唾液和血清生物标志物在识别易患舍格伦病（SD）的牙科患者中的作用， 改善患者结局，管理有SD风险的患者，并通过跨专业人员进行管理 牙科临床医生（DC）、药剂师、风湿病学家和患者之间的沟通和协作。这 应用是重要的，因为它寻求1）提高下一代发展中国家的知识和技能， 进行和领导PBR，2）通过虚拟健康平台促进专业间的沟通和护理， 解决牙科患者的状况，如需要多学科专业知识进行及时诊断的SD， 管理和3）开发唾液功能减退指数与唾液生物标志物的组合，以检测 易患SD的患者，从而改善有SD风险的患者的共同决策和管理。 结果包括DC学生和教师完成临床研究的可衡量的增加， 指导培训和参与拟议的PBR研究，验证生物标志物以早期发现 PBR环境中的SD，以及与其他卫生保健提供者协调护理的改进。拟议 研究是重要的，因为它为多学科团队诊断和管理奠定了基础 社区实践环境中受SD影响的个人，并减少目前由于 分散和孤立的牙科医疗保健。

Project Summary Practice-based research (PBR) has demonstrated effectiveness to integrate evidence-based care into clinical practice, enhance the generalizability of research findings and conduct longitudinal studies not possible through traditional randomized controlled studies. The PBR Networks (PBRN) in medicine began in 1970 and have played a crucial role in advancing medical research findings and translating research evidence to practice settings to enhance patient outcomes. The National Institute of Dental and Craniofacial Research (NIDCR) established the Dental Practice-Based Research Network in 2005 and it is now considered to be the largest dental PBRN in the world. However, PBR experiences have yet to become part of the dental predoctoral/postdoctoral curriculum. According to NIDCR, it is essential to ‘engage dental students in research activities and incorporate evidence-based principles into the dental curriculum to enhance their critical thinking skills to evaluate and incorporate new knowledge into practice.’ In this application, the Indiana University (IU) School of Dentistry (IUSD) investigators with expertise in basic science, PBR, informatics, and salivary diagnostics have established collaborations with the Indiana Clinical and Translational Science Institute (CTSI), IU School of Medicine (IUSM), Purdue College of Pharmacy, Regenstrief Institute, Inc. and Indiana Health Information Exchange to advance clinical research training of dental clinical faculty and trainees, and strengthen research mentoring partnership amongst students, clinical faculty and researchers. We will advance knowledge of salivary and serum biomarkers in identifying dental patients susceptible to Sjögren’s Disease (SD), thus improving patient outcomes and management of patients at risk for SD and manage through interprofessional communication and collaboration of dental clinicians (DC), pharmacists, rheumatologists, and patients. This application is significant because it seeks to 1) advance the knowledge and skills of next-generation DCs to conduct and lead PBR, 2) facilitate interprofessional communication and care via virtual health platforms to address dental patients’ conditions such as SD that require multidisciplinary expertise for timely diagnosis and management and 3) develop a salivary hypofunction index in combination with salivary biomarkers to detect patients susceptible to SD thus improving shared decision making and management of patients at risk for SD. The outcomes include measurable increases in DC students and faculty completing clinical research and mentoring training and participation in the proposed PBR study, validation of biomarkers for early detection of SD in PBR settings, and improvement in coordinating care with other health care providers. The proposed research is significant because it lays the foundation for multidisciplinary teams to diagnose and manage individuals affected with SD in community practice settings and reduce current delays in diagnosis due to fragmented and siloed dental-medical care.