Ssimusango: Multi-level intervention for intersectional stigma reduction to improve HIV outcomes for transgender women

西穆桑戈：多层次干预减少交叉耻辱，以改善跨性别女性的艾滋病毒结果

• 批准号: 10755926
• 负责人: Andrew Mujugira
• 金额: $ 18.62万
• 依托单位: INFECTIOUS DISEASES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10755926
• 关键词: AIDS prevention; Address; Adherence; Adoption; Adult; Africa South of the Sahara; African; Caring; Catchment Area; Clinic; Clinical; Clinical Trials; Communities; Consolidated Framework for Implementation Research; Consultations; Data; Disclosure; Discrimination; Education; Effectiveness; Empathy; Enrollment; Equity; Evaluation; Face; Feedback; Focus Groups; Fright; Gender Identity; General Population; HIV; HIV Infections; Health Personnel; Health Policy; Health Services; Health Status; Health care facility; Healthcare; High Risk Woman; Human immunodeficiency virus test; Hybrids; Incidence; Individual; Institution; Intervention; Interview; Manuals; Measures; Modeling; Outcome; Population; Prevalence; Prevention; Qualitative Methods; RNA; Randomized; Research; Risk; Sampling; Services; Sex Orientation; Stigmatization; Surveys; Tenofovir; Testing; Training; Uganda; Urine; Viral; Waiting Lists; Well in self; Woman; Work; acceptability and feasibility; aged; antiretroviral therapy; effectiveness evaluation; effectiveness/implementation trial; empowerment; evidence base; experience; gender minority; health assessment; health care settings; health training; implementation evaluation; implementation intervention; implementation outcomes; improved; informant; internalized stigma; intersectionality; intervention delivery; marginalized population; men; men who have sex with men; multidisciplinary; peer; perceived discrimination; pilot test; post intervention; pre-exposure prophylaxis; prevention service; primary outcome; programs; residence; response; scale up; secondary outcome; sex; social stigma; standard of care; synergism; therapy adherence; therapy design; transgender; transgender women; treatment services; uptake

PROJECT SUMMARY/ABSTRACT Transgender women (TGW) are at high risk for HIV infection, and are an important, under-researched key population in sub-Saharan Africa. Globally, HIV acquisition risk among TGW is 14 times higher than other adults aged 15-49 years. Intersectional stigma and discrimination (ISD) experienced by TGW at the intersections of HIV, sexual orientation, gender minority identity and sex work results in poor engagement in care and suboptimal adherence to HIV pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART). Much work remains in addressing HIV-related ISD and scaling up treatment and prevention coverage for TGW. Two evidence-based ISD-reduction interventions are available -- (1) Health Policy Plus (HP+) Total Facility Approach (TFA) to Stigma Reduction (a clinic-level intervention) and (2) HIV Education, Empathy and Empowerment (HIVE3) (an individual- level intervention) -- but these have not been adapted and implemented for TGW in sub-Saharan Africa. HP+ and HIVE3 are complementary interventions that could be combined to reduce health facility- and individual-level stigma. However, research is needed to show if the adapted multi-level HP+/HIVE3 intervention, Ssimusango (means “no self-blame or blaming others” in Luganda), decreases HIV-related stigma and improves HIV outcomes for TGW. To address these questions, we will conduct a randomized wait-list controlled trial to test the preliminary effectiveness of Ssimusango on PrEP adherence and viral suppression, compared with standard of care, using a status-neutral approach i.e., engagement in care regardless of HIV status. We will also use qualitative methods to assess mechanisms and synergies of intervention delivery. Leveraging the multi- disciplinary expertise of our multi-national research team, and working at four health facilities in Kampala ranked lowest on the PEPFAR Uganda stigma scorecard, we propose the following specific aims: (1) adapt the HP+ and HIVE3 stigma-reduction interventions to address ISD for TGW in Uganda (intervention adaptation); (2) conduct a hybrid type 1 effectiveness-implementation trial with 120 TGW to pilot test the preliminary effectiveness of Ssimusango on (a) PrEP adherence and (b) viral suppression (intervention implementation); and (3) evaluate Ssimusango using qualitative methods and the Intersectionality-Enhanced Consolidated Framework for Implementation Research (intervention evaluation). Clinic-level implementation outcomes are adoption, fidelity, and sustainability assessed using key informant interviews, training attendance sheets, observation checklists, and rapid feedback surveys. Individual-level outcomes: (1) PrEP adherence at 3 and 6 months post-intervention, measured by urine tenofovir levels (primary outcome) and (2) viral suppression (HIV RNA <50 copies/mL) and (3) ISD reduction 6 months post-intervention (secondary outcomes). This multi-level approach to implementing ISD interventions will improve PrEP and ART adherence outcomes among TGW - “the most vulnerable of the vulnerable” -, build stigma research capacity in Uganda, and generate actionable data for scale-up and program implementation in Uganda and sub-Saharan Africa.

项目总结/文摘