权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The Effects of Prenatal Thirdhand E-cigarette Exposure on Platelets

产前三手电子烟暴露对血小板的影响

基本信息

批准号：
10759130
负责人：
Fadi T Khasawneh
金额：
$ 2.6万
依托单位：
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10759130
关键词：
Address Animal Diseases Animal Model Biochemical Markers Biology Blood Blood Platelets C-reactive protein Cardiovascular Diseases Cardiovascular system Cigarette Critical Thinking Data Deposition Development Disease Electronic cigarette Electronics Elements Exposure to Foundations Funding Future Gender Goals Health Hemostatic function Home Human Hyperactivity Ingestion Inhalation Laboratories Light Mediating Mentors Minority Nature Pathogenesis Persons Phenotype Plasma Platelet Activation Platelet Count measurement Play Policies Prevention Process Publishing Risk Role Safety Scientist Skin Absorption Smoke Smoking Societies Surface System Testing Therapeutic Thrombosis Time Tobacco Tobacco smoke Toxic effect Training Vulnerable Populations Writing cardiovascular health chemical reaction clinically relevant combustible cigarette design electronic hookah evidence base experimental study exposed human population exposure route in utero novel platelet function pre-doctoral prenatal prenatal exposure research study response sex skills smoking cessation thirdhand smoke thrombogenesis tobacco products toxicant

项目摘要

While smoking has been on the decline, Electronic Delivery Systems (ENDS) usage has been on the rise; especially in vulnerable populations. Furthermore, even though the contribution of in utero third-hand smoke (THS) and e-cigarettes to the pathogenesis of thrombotic diseases have recently been documented, the involvement of prenatal third-hand e-hookah (another form of ENDS) in such disease processes remains unknown. Consequently, the present application outlines studies that address fundamental, mechanistic, and clinically-relevant translational aspects of the adverse-health effects of prenatal thirdhand e-hookah, in the context of thrombotic disease and platelet biology, and in a sex-specific manner. These studies are of paramount significance given the “perceived safety” of e-hookahs. The Aims of this proposal are: Aim 1. Investigate the impact of prenatal thirdhand e-hookah exposure on platelet-dependent disease states. While there is compelling evidence that e-cigarettes and in utero thrdhand smoke from traditional cigarettes (THS) do exert negative health effects, the impact of prenatal thirdhand e-hookah on platelet- dependent diseases is still unknown. To address this issue, the consequences of prenatal thirdhand e-hookah exposure on normal hemostasis and platelet counts will be determined. Subsequent studies will examine whether it participates in the development of thrombosis-based disease, and exerts effects on a plasma “marker” of thrombosis. Notably, experiments will be designed in a manner that addresses the role of sex in mediating the “platelet”-dependent negative effects of prenatal thirdhand e-hookah. Aim 2. Investigate the mechanism by which prenatal thirdhand e-hookah exposure modulates platelet function. Even though published data indicate that in utero THS and e-cigarettes modulate platelet activation, whether prenatal thirdhand e-hookah produces similar effects (i.e., the mechanism by which it modulates platelet function) remains to be investigated. Thus, the overall goal of the mechanistic experiments proposed in this section is to determine the impact of prenatal thirdhand e-hookah exposure on the various platelet functional responses (e.g., GPIIb-IIIa activation) and biochemical “markers” of platelet activation. Collectively, these experiments will make significant contributions to the understanding of the consequences of prenatal thirdhand e-hookah/e-hookah on platelet activation and cardiovascular human health, and the mechanism by/through which it exerts these effects, in a sex-specific manner.

在吸烟人数下降的同时，电子传送系统（ENDS）的使用率却在上升；