Spatial repellents to reduce the outdoor transmission of malaria

空间驱虫剂可减少疟疾的户外传播

• 批准号: 10907059
• 负责人: Ingrid Ting-Ting Chen
• 金额: $ 4.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10907059
• 关键词: Achievement; Affect; Africa; Area; Beds; Bite; Cambodia; Cambodian; Characteristics; Climate; Culicidae; Data; Detergents; Disorientation; Entomology; Evolution; Formulation; Foundations; Frequencies; Future; Health behavior change; High temperature of physical object; Human; Humidity; Insecticides; Interruption; Intervention; Intervention Studies; Latin America; Malaria; Mentorship; Meta-Analysis; Pharmaceutical Preparations; Publishing; Rain; Research; Research Design; Research Personnel; Residual state; Shapes; Source; Southeastern Asia; Surface; Tanzania; Temperature; Testing; Textiles; Thailand; Theory of Change; Time; Training; Volatilization; Water; Weather; design; evidence base; experience; field study; forest; high risk population; malaria transmission; preference; protective efficacy; public health intervention; scale up; skills; small molecule; therapy design; therapy development; transmission process; uptake; vector

ABSTRACT Despite the recognized and urgent need for public health interventions that interrupt outdoor malaria transmission, no such proven interventions are available. Transfluthrin-treated hessian fabric strips (TTHFS) offer promise, showing more than six months of mosquito bite deterrence in Tanzanian settings. This project seeks to clarify and advance the evidence base on TTHFS through meta-analysis of Tanzanian studies, semi- field and field testing in Thailand and Cambodia, and user acceptability studies in Cambodia to inform future studies and intervention designs. Aim 1: To determine the relationship between TTHFS characteristics and their protective efficacy over time in Tanzania. I hypothesize that an optimal transfluthrin concentration, fabric strip size, and temperature range for TTHFS can be identified from prior studies in Tanzania, and that impacts on efficacy caused by high temperature and relative humidity can be quantified. Aim 2: To investigate the protective efficacy of TTHFS over time in Thai and Cambodian outdoor conditions. I hypothesize that TTHFS that are efficacious in Tanzania will show similar levels of efficacy in a very different setting against Thai and Cambodian malaria vectors, with similar effects of temperature and humidity on the duration of efficacy. Aim 3: To establish user acceptability and identify modifiable barriers to TTHFS uptake among Cambodian forest rangers and forest goers. I hypothesize that Cambodian forest rangers and forest goers will find TTHFS acceptable due to their ability to reduce mosquito bites, but will be uncomfortable with the product given their limited experience with TTHFS and will have preferences on the size, shape, and design of TTHFS. This study will inform a future interventional study of an optimized TTHFS in Southeast Asia, to be performed subsequent to this K01 study.

抽象的 尽管人们认识到迫切需要采取公共卫生干预措施来阻断户外疟疾 传播，目前尚无此类行之有效的干预措施。经过四氟苯菊酯处理的粗麻布条 (TTHFS) 提供承诺，展示了坦桑尼亚环境中六个月以上的蚊虫叮咬威慑作用。这个项目 旨在通过坦桑尼亚研究的荟萃分析来澄清和推进 TTHFS 的证据基础，半 在泰国和柬埔寨进行现场和现场测试，并在柬埔寨进行用户可接受性研究，为未来提供信息 研究和干预设计。 目标 1：确定 TTHFS 特征与其保护功效之间的关系 坦桑尼亚时间。我假设最佳四氟苯菊酯浓度、织物条尺寸和温度 TTHFS 的范围可以从坦桑尼亚的先前研究中确定，并且高浓度对疗效的影响 温度和相对湿度可以量化。 目标 2：调查 TTHFS 在泰国和柬埔寨户外活动中随时间的保护效果 状况。我假设在坦桑尼亚有效的 TTHFS 将在其他国家表现出类似的功效水平。 泰国和柬埔寨疟疾媒介的环境非常不同，温度和温度的影响相似 湿度对药效持续时间的影响。 目标 3：建立用户可接受性并确定可改变的 TTHFS 吸收障碍 柬埔寨护林员和森林游客。我假设柬埔寨护林员和森林游客 会发现 TTHFS 可以接受，因为它们能够减少蚊虫叮咬，但会对 鉴于他们对 TTHFS 的经验有限，并且会对产品的尺寸、形状和设计有偏好 TTHFS。 这项研究将为未来在东南亚进行的优化 TTHFS 干预研究提供信息 在这项 K01 研究之后。