STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vitro immunomodulation
评估环境潜力的研究
基本信息
- 批准号:10906728
- 负责人:
- 金额:$ 21.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-13 至 2024-08-12
- 项目状态:已结题
- 来源:
- 关键词:AllergensAnimalsAutoimmune DiseasesBiological AssayBlindedChemical AgentsChemicalsCodeCollaborationsCommunicable DiseasesContractsDataData CollectionDermalDevelopmentEventExposure toFood AdditivesGene Expression ProfilingHazard IdentificationHealthHealth HazardsHematopoieticHumanHuman Cell LineHypersensitivityImmunologic TechniquesImmunologicsImmunosuppressionImmunotoxicologyIn VitroLaboratoriesMeasuresMethodsMolecularNational Toxicology ProgramNeoplasmsPeptidesPharmaceutical PreparationsPredictive ValuePreparationReportingResearchResistanceSkinStructureTechniquesTestingTherapeutic AgentsValidationXenobioticsdietary supplementsenvironmental agentexposed human populationimmune functionimmune system functionimmunoregulationimmunotoxicityin vitro Modelin vitro testingin vivokeratinocyteprogramsrespiratoryresponsescreening
项目摘要
In vitro techniques for hazard identification for potential sensitizers have been of increasing importance to the NIEHS. A research collaboration agreement with a commercial vendor was established to assess the utility of the GARDair assay to identify respiratory sensitizers. As an extension of the previously reported agency partner studies where >200 chemicals were evaluated using in vitro methods to assess their potential to induce skin sensitization, NIEHS requested nominations from partner agencies to evaluate the use of an in vitro method to evaluate chemicals for their potential to induce allergic responses in the lung. The GARDair assay uses a gene set that has potential for identifying respiratory sensitizers. Agency partners nominated a total of 100 chemicals to be tested, including known respiratory sensitizers as well as chemicals of unknown potential to induce sensitization. BRT completed procurement of the chemicals in FY23 and the laboratory studies are ongoing. To date, 20 chemicals have passed range finder assays and the main runs are completed. NIEHS funded BRT participation in validation trials for the Electrophilic Allergen Screening Assay (EASA). This assay uses non-protein/peptide probes in a cell-free assessment to measure the ability of a test substance to “react” with biologically important molecules for the identification of electrophilic allergic contact dermatitis hazards. Data collection for these chemicals was completed in FY22 and the study method transfer and validation reports were completed and closed in FY23.
潜在致敏剂危害识别的体外技术对于 NIEHS 来说越来越重要。我们与一家商业供应商签订了研究合作协议,以评估 GARDair 检测方法识别呼吸道致敏物的效用。作为先前报道的机构合作伙伴研究的延伸,其中使用体外方法评估了超过 200 种化学品,以评估其诱发皮肤过敏的潜力,NIEHS 要求合作机构提名,以评估使用体外方法来评估化学品诱发肺部过敏反应的潜力。 GARDair 检测使用具有识别呼吸致敏剂潜力的基因组。机构合作伙伴提名了总共 100 种化学物质进行测试,包括已知的呼吸道致敏物以及未知潜在诱发致敏作用的化学物质。 BRT 在 2023 财年完成了化学品采购,实验室研究正在进行中。迄今为止,20 种化学品已通过测距仪检测,主要运行已完成。 NIEHS 资助 BRT 参与亲电过敏原筛查测定 (EASA) 的验证试验。 该测定在无细胞评估中使用非蛋白质/肽探针来测量测试物质与生物学重要分子“反应”的能力,以识别亲电子过敏性接触性皮炎危害。这些化学品的数据收集已于 2022 财年完成,研究方法转移和验证报告已于 2023 财年完成并结束。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('FLORENCE BURLESON', 18)}}的其他基金
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vitro hypersensitivity
评估环境潜力的研究
- 批准号:
10421165 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
Enabling risk-based testing through characterization of environmentally induced immune dysregulation and susceptibility to the SARS-CoV2 virus and COVID-19
通过表征环境引起的免疫失调以及对 SARS-CoV2 病毒和 COVID-19 的易感性,实现基于风险的测试
- 批准号:
10906729 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vivo
评估环境潜力的研究
- 批准号:
10209928 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY
评估环境潜力的研究
- 批准号:
8937071 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vivo
评估环境潜力的研究
- 批准号:
10023392 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY
评估环境潜力的研究
- 批准号:
9129580 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
Enabling risk-based testing through characterization of environmentally induced immune dysregulation and susceptibility to the SARS-CoV2 virus and COVID-19
通过表征环境引起的免疫失调以及对 SARS-CoV2 病毒和 COVID-19 的易感性,实现基于风险的测试
- 批准号:
10682371 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vitro
评估环境潜力的研究
- 批准号:
10023468 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vivo
评估环境潜力的研究
- 批准号:
10906727 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vivo
评估环境潜力的研究
- 批准号:
10421164 - 财政年份:2014
- 资助金额:
$ 21.65万 - 项目类别:
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