Reducing HIV vaccine and prevention hesitancy among sexual and gender minority adolescents

减少性少数和性别少数青少年对艾滋病毒疫苗和预防的犹豫

• 批准号: 10620502
• 负责人: Brandon J Hill
• 金额: $ 65.67万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-16 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620502
• 关键词: AIDS prevention; Accounting; Address; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Area; Attitude; Awareness; Behavior; Behavioral; Belief; Bisexual; Black, Indigenous, People of Color; COVID-19 pandemic; COVID-19 vaccine; Chicago; Clinic; Clinical; Communities; Development; Education; Effectiveness; Ensure; Epidemic; Exposure to; Face; Feedback; Focus Groups; Fostering; Friends; Future; Gays; HIV; HIV vaccine; HIV/STD; Health; Human Papilloma Virus Vaccine; Hybrids; Industry; Infection; Injectable; Intervention; Interview; Knowledge; Learning; Media Campaign; Medical; Methods; Misinformation; Modeling; Motivation; Oral; Outcome; Participant; Perception; Persons; Predisposition; Prevention; Prevention approach; Prevention strategy; Primary Prevention; Production; Proxy; Public Health; Randomized, Controlled Trials; Research; Safety; Sampling; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Source; Stream; Surveys; Teenagers; Testing; Time; Trust; United States; Vaccines; Work; Youth; adolescent HIV prevention; age group; behavior change; boys; burden of illness; condoms; design; effectiveness testing; effectiveness/implementation design; girls; health communication; implementation intervention; improved; insight; minority children; novel; peer; phase I trial; post intervention; pre-exposure prophylaxis; preference; preventive intervention; randomized trial; recruit; social media; social norm; social stigma; success; therapy development; transgender; truvada; uptake; vaccine acceptance; vaccine distribution; vaccine efficacy; vaccine refusal

Project Summary Adolescents and young adults are disproportionately affected by HIV in the USA, accounting for 21% of new infections, with sexual and gender minority (SGM) youth carrying the greatest burden of disease. Recently, phase I trials of potential HIV vaccines have opened possibilities for more prevention options available to youth (in addition to oral and injectable PrEP). However, implementation of biomedical HIV prevention (e.g., PrEP) among youth is hindered by numerous barriers that will likely affect HIV vaccine uptake, including misinformation/lack of information, medical mistrust, and stigma. Youth-focused messaging on biomedical HIV prevention is nearly nonexistent, leaving SGM teens with incomplete knowledge and fostering misunderstanding and negative perceptions about biomedical HIV prevention methods. In addition, lessons learned from the rollout of the HPV and COVID-19 vaccines indicate that unclear public health messaging, dis- or misinformation from media/online sources, and vaccine stigma contributed to lack of trust, delayed uptake, or outright refusal of vaccines. As HIV vaccines are in development, and PrEP remains underutilized among SGM adolescents, now is the best time to understand and address biomedical HIV prevention concerns and misinformation among youth. Therefore, this study proposes to preemptively debunk (i.e., “prebunk”) misinformation about HIV vaccines, improve attitudes regarding multiple methods of biomedical HIV prevention, and improve awareness, intentions, and uptake among SGM youth. In Aim 1, using an online survey, we will gain comprehensive understanding of biomedical-HIV-prevention-related knowledge, social norms and attitudes, and behavioral intent among a diverse nationwide sample of 700 SGM youth age 13-21. In Aim 2, we will develop 8 brief youth-centered video vignettes aimed at prebunking vaccine misinformation and presenting one or more complementary biomedical prevention methods (vaccine, PrEP, condoms). These video messages will be delivered through narrative storytelling formats that are relevant, compelling, and persuasive for youth. We will obtain feedback about the video vignettes from SGM youth and adult stakeholders at multiple timepoints during video production and integrate this feedback into the final cuts. In Aim 3, we will test the effectiveness of our messages in a randomized controlled trial with 500 SGM youth, which will compare the video messages against an information-only control (e.g., publicly available information from CDC on HIV vaccines and other forms of biomedical prevention). Three-month post-test outcomes include vaccine acceptability and intentions, vaccine beliefs, and proxies for vaccine uptake (e.g., prevention information seeking, HIV/STI testing, PrEP initiation.) Within this aim, we will also explore barriers and facilitators to online- and in-person implementation via interviews with staff in community/clinical settings and experts in entertainment education and streaming media.

项目总结