Pre-exposure prophylaxis (PrEP) information on social media

项目摘要 美国持续的艾滋病毒流行仍然是年轻优先人群面临的关键健康问题 不成比例的感染负担。每日口服PrEP(截至2021年12月，长效注射剂 卡替格列韦)在降低成人和青少年获得性感染艾滋病毒的风险方面是安全有效的，但 备考意识/使用率仍然较低。因此，迫切需要干预措施来提高对PrEP的认识 并缓解与PrEP使用相关的潜在障碍。一种这样的干预方式是社交媒体(SM)，如艾滋病毒 知识、PrEP意识和沟通问题(如接入和成本)都可以通过以下方式轻松解决 在年轻人已经经常使用的平台上发布清晰的短信。鉴于PrEP的认知/使用情况 仍然较低，SM可能是增加PrEP促进者和减少 障碍，这个拟议的探索性研究项目的总体目标是1)表征SM景观 关于PrEP和艾滋病毒预防信息和2)发展新的和改进的行为理论为基础 关于PrEP的信息是明确、具体、一致和科学上最新的。具有健壮的和 跨两个机构的多学科团队，我们将通过三个具体目标实现这一目标：目标1： 描述3个流行的社交媒体平台(Facebook、 Instagram和Twitter)，识别消息和来源特征。使用内容分析方法， 我们将访问、人工编码和分析公开可用的PrEP相关SM帖子/消息，描述 消息、海报/用户和社交网络的功能。目标2：建立一种可预测、可解释的健康 沟通模型，以模因扩散的多水平模型(M3D)为指导，以确定 PrEP相关消息的扩散潜力。我们将应用机器学习方法来表征PrEP 消息特征；使用大规模开发/评估消息扩散潜力的预测模型 训练数据；以及应用该模型来预测给定消息的一组在线扩散度量并评估其 能够接触到与PrEP相关的在线人群。目标3：制定和试行PrEP宣传信息， 对于几个年轻的优先群体，供在未来的项目中实施/评估。使用人类- 按照以设计为中心(HCD)的原则，我们将让2-3个终端用户群参与SM消息的迭代轮次 开发和测试。建议的R21将使您更深入地了解PrEP促销信息 并制作了一个“信息库”，为几个有艾滋病毒风险的年轻优先人群量身定做。是这样的 消息将在未来的R01项目中进行经验性测试，并评估行为变化的证据(即， 准备用法)。这样的知识可用于创新/有针对性的工作，通过良好的点赞和可访问 数字工具，如SM，有效地支持更新的美国国家艾滋病毒/艾滋病战略

Project Abstract The continuing HIV epidemic in the U.S. remains a critical health issue for young priority populations bearing a disproportionate burden of infection. Daily oral PrEP (and as of December 2021, a long-acting injectable cabotegravir) is safe and effective in reducing the risk of sexual HIV acquisition in adults and adolescents, yet PrEP awareness/usage remains low. Accordingly, interventions are sorely needed to address PrEP awareness and mitigate potential barriers related to PrEP use. One such intervention modality is social media (SM), as HIV knowledge, PrEP awareness, and communicating issues, such as access and cost, are easily addressable via clear SM messages on platforms young people already use frequently. Given that PrEP awareness/usage remains low and that SM may be a viable intervention modality for increasing PrEP facilitators and reducing barriers, the overall objective of this proposed exploratory research project is to 1) characterize the SM landscape regarding PrEP and HIV prevention messages and 2) develop new and improved behavioral theory-based messages about PrEP that are clear, specific, consistent, and scientifically up to date. With a robust and multidisciplinary team across 2 institutions, we will accomplish this objective via 3 SPECIFIC AIMS: AIM 1: Characterize PrEP-related communications across 3 popular social media platforms (Facebook, Instagram, and Twitter), identifying message and source characteristics. Using content analytic methods, we will access, human code, and analyze publicly available PrEP-related SM posts/messages, describing features of messages, posters/users, and social networks. AIM 2: Build a predictive, explainable health communication model, guided by the Multilevel Model of Meme Diffusion (M3D), to determine the diffusion potential of PrEP-related messages. We will apply machine learning methods to characterize PrEP message features; develop/evaluate a predictive model of a message diffusion potential using large-scale training data; and apply the model to predict a set of online diffusion metrics for a given message and assess its ability to reach online PrEP-relevant populations. AIM 3: Develop and pilot test PrEP promotion messages, for several young priority populations, for implementation/evaluation in a future project. Using human- centered design (HCD) principles, we will engage 2-3 end-user segments in iterative rounds of SM message development and testing. This proposed R21 will yield a deeper understanding of PrEP promotion messaging on SM and produce a “library of messages,” tailored for several young priority populations at risk for HIV. Such messages will be empirically tested in a future R01 project, and assessed for evidence of behavior change (i.e., PrEP usage). Such knowledge may be employed in innovative/targeted efforts via well-liked and accessible digital tools, such as SM, effectively supporting the updated National HIV/AIDS Strategy for the U.S.