Pre-exposure prophylaxis (PrEP) information on social media

社交媒体上的暴露前预防 (PrEP) 信息

• 批准号: 10619946
• 负责人: Eric Richard Walsh-Buhi
• 金额: $ 21.02万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-09 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10619946
• 关键词: 18 year old; AIDS prevention; Address; Adherence; Adolescent; Adult; Anal Sex; Area; Awareness; Behavioral; Bisexual; Black Populations; Black race; Characteristics; Clinic; Clinical Trials; Code; Cohort Studies; Communication; Couples; Data; Development; Diffusion; Education; Epidemic; Evaluation; FDA approved; Facebook; Future; Gays; HIV; HIV Infections; HIV Seronegativity; HIV diagnosis; HIV risk; HIV/AIDS; Health; Heterosexuals; Human; Human immunodeficiency virus test; Individual; Injectable; Injecting drug user; Instagram; Institution; Intervention; Knowledge; Lesbian; Lesbian Gay Bisexual Transgender Queer; Libraries; Methods; Modality; Modeling; Oral; Persons; Population; Populations at Risk; Prevention; Prevention strategy; Probability; Reporting; Research; Research Project Grants; Risk; Risk Reduction; Sampling; Services; Social Marketing; Social Network; Source; Testing; Theory of Change; Training; Twitter; Update; Youth; aged; analytical method; behavior change; black men who have sex with men; cis-male; condoms; cost; design; digital tool; evidence base; gender diversity; health communication; human centered design; improved; infection burden; innovation; machine learning method; medication compliance; men; men who have sex with men; multidisciplinary; multilevel analysis; new technology; nonbinary; pilot test; posters; pre-exposure prophylaxis; predictive modeling; recruit; sexually active; social influence; social media; social stigma; study population; theories; transgender; transgender women; uptake

Project Abstract The continuing HIV epidemic in the U.S. remains a critical health issue for young priority populations bearing a disproportionate burden of infection. Daily oral PrEP (and as of December 2021, a long-acting injectable cabotegravir) is safe and effective in reducing the risk of sexual HIV acquisition in adults and adolescents, yet PrEP awareness/usage remains low. Accordingly, interventions are sorely needed to address PrEP awareness and mitigate potential barriers related to PrEP use. One such intervention modality is social media (SM), as HIV knowledge, PrEP awareness, and communicating issues, such as access and cost, are easily addressable via clear SM messages on platforms young people already use frequently. Given that PrEP awareness/usage remains low and that SM may be a viable intervention modality for increasing PrEP facilitators and reducing barriers, the overall objective of this proposed exploratory research project is to 1) characterize the SM landscape regarding PrEP and HIV prevention messages and 2) develop new and improved behavioral theory-based messages about PrEP that are clear, specific, consistent, and scientifically up to date. With a robust and multidisciplinary team across 2 institutions, we will accomplish this objective via 3 SPECIFIC AIMS: AIM 1: Characterize PrEP-related communications across 3 popular social media platforms (Facebook, Instagram, and Twitter), identifying message and source characteristics. Using content analytic methods, we will access, human code, and analyze publicly available PrEP-related SM posts/messages, describing features of messages, posters/users, and social networks. AIM 2: Build a predictive, explainable health communication model, guided by the Multilevel Model of Meme Diffusion (M3D), to determine the diffusion potential of PrEP-related messages. We will apply machine learning methods to characterize PrEP message features; develop/evaluate a predictive model of a message diffusion potential using large-scale training data; and apply the model to predict a set of online diffusion metrics for a given message and assess its ability to reach online PrEP-relevant populations. AIM 3: Develop and pilot test PrEP promotion messages, for several young priority populations, for implementation/evaluation in a future project. Using human- centered design (HCD) principles, we will engage 2-3 end-user segments in iterative rounds of SM message development and testing. This proposed R21 will yield a deeper understanding of PrEP promotion messaging on SM and produce a “library of messages,” tailored for several young priority populations at risk for HIV. Such messages will be empirically tested in a future R01 project, and assessed for evidence of behavior change (i.e., PrEP usage). Such knowledge may be employed in innovative/targeted efforts via well-liked and accessible digital tools, such as SM, effectively supporting the updated National HIV/AIDS Strategy for the U.S.

项目摘要 美国持续的艾滋病毒流行仍然是年轻优先人群的一个关键健康问题， 不成比例的感染负担。每日口服PrEP（以及截至2021年12月，长效注射 cabotegravir）在降低成人和青少年性感染HIV的风险方面是安全有效的， PrEP意识/使用率仍然很低。因此，迫切需要采取干预措施来提高PrEP意识 并减少与PrEP使用相关的潜在障碍。一种这样的干预方式是社交媒体（SM），如艾滋病毒 知识，PrEP意识和沟通问题，如访问和成本，可以通过以下方式轻松解决： 在年轻人经常使用的平台上发布明确的SM信息。鉴于PrEP意识/使用 仍然很低，SM可能是一种可行的干预方式，用于增加PrEP促进者和减少 障碍，这个拟议的探索性研究项目的总体目标是1）描述SM景观 关于PrEP和艾滋病毒预防信息，2）开发新的和改进的基于行为理论的 关于PrEP的信息是明确的，具体的，一致的，科学上最新的。凭借强大的 跨2个机构的多学科团队，我们将通过3个具体目标实现这一目标：目标1： 描述3个流行社交媒体平台（Facebook， Instagram和Twitter），识别消息和源特征。利用内容分析方法， 我们将访问、人工编码和分析公开的PrEP相关SM帖子/消息， 消息、海报/用户和社交网络的特征。目标2：建立可预测的、可解释的健康 传播模型，由模因扩散的多层次模型（M3 D）指导，以确定 PrEP相关信息的扩散潜力。我们将应用机器学习方法来表征PrEP 信息特征;开发/评估使用大规模信息传播潜力的预测模型 训练数据;以及应用该模型来预测给定消息的一组在线扩散度量，并评估其 接触在线PrEP相关人群的能力。目标3：制定和试点测试PrEP推广信息， 为几个年轻的重点人群，在未来的项目中实施/评估。使用人类- 中心设计（HCD）原则，我们将在SM消息的迭代轮中吸引2-3个最终用户部分 开发和测试。这一拟议的R21将使人们更深入地了解PrEP推广信息 关于性行为和性虐待的信息，并为几个有艾滋病毒风险的青年优先群体量身定制“信息库”。等 消息将在未来的R 01项目中进行经验性测试，并评估行为变化的证据（即， PrEP使用）。这些知识可以通过广受欢迎和可访问的 数字化工具，如SM，有效地支持更新的美国国家艾滋病毒/艾滋病战略。