PRECISE-TBI: PRE Clinical lnteragency research resourcE-TBI

项目总结 该项目的主要任务是建立一个名为临床前机构间研究的中心 以加速治疗为使命的资源型颅脑损伤(PRECISE-TBI) 对于TBI。PRECIST-TBI将通过使用企业方法来实现关键目标，从而实现这一使命 有针对性的战略。我们还将利用之前的合作努力。该公司的组织结构 Precision-TBI融合了来自商业模式和其他研究联盟的元素。战略上的 中心的任务分为五个核心，并将通过核心的活动实现里程碑 董事和成员。Precision-TBI的领导层将担任核心董事(Dixon博士、Gurkoff博士、 范德沃德、马托内、拉普拉卡、哈里斯、弗洛伊德)和指导委员会主席亚当·弗格森博士。 领导层将与指导委员会(由代表临床专业知识的人员、其他 退伍军人管理局项目、其他机构和所有模型类型)，以设定目标、里程碑和交付成果。我们会 有一个社区委员会将由100多人组成，具有广泛的TBI知识和观点。 委员会成员将分为以任务为导向的小组委员会，由 领导层和指导委员会。核心董事、指导委员会主席和指导 委员会成员经过精心挑选，以提供多样性和包容在TBI的专业知识、地理位置 地点、资助历史、性别认同、资历和研究重点。在急性和慢性脑外伤方面的专业知识 此外，还将包括儿科脑外伤模型。来自业界和非牟利组织的代表包括 包括在指导委员会中。行政主任/科学撰稿人将撰写文件草稿，以供最后敲定 委员会成员。Precision-TBI的组织结构将两个方向的研究人员联系在一起 委员会和社区委员会，以促进效率和广泛的参与。每一个 核心有一个总体目标，将通过目标和里程碑来实现。世界银行的使命是 行政管理的核心是促进所有要素之间有效和高效的沟通和互动 精准的-TBI。工作观点是，TBI调查员将既充当“雇员”，又充当 “顾客。”这一双重角色是因为TBI调查人员将被聘用来开发(员工)和使用 (客户)共识声明和翻译路线图。临床前研究的首要目标 模式目录的核心是创建、分发和维护临床前的在线目录 脑损伤模型以及创建对人类脑损伤具有本体论意义的临床前脑损伤结果数据库 病理学。公共数据元素的核心任务是开发新的和现有的数据元素并对其进行基准测试 使用来自资助财团的现有数据和来自新项目的数据的通用数据元素。这个 信息学核心寻求通过开发和实施 研究人员友好的基础设施，支持数据共享并实施标准和实践，以制定 临床前TBI数据可查找、可访问、可互操作和可重复使用(FAIR)。野战特种部队的使命 计划协调核心是通过以下方式在中心和更大的TBI社区之间架起桥梁 利用现有基础设施并发展互动社区以使用中心资源。总而言之， Precision-TBI的领导层、指导委员会、社区委员会和核心将支持和 加快开发治疗脑外伤的新候选疗法。

PROJECT SUMMARY The overarching mission of this project is to develop a Center entitled PRE-Clinical Interagency reSearch resourcE-Traumatic Brain Injury (PRECISE-TBI) with the mission of accelerating the development of therapies for TBI. PRECISE-TBI will achieve this mission by utilization of an enterprise approach to meet key objectives with targeted strategies. We will also leverage previous collaborative efforts. The organizational structure of PRECISE-TBI incorporates elements from business models and from other research consortia. The strategic missions of the Center are divided into five Cores and milestones will be achieved by activities of Core Directors and members. Leadership of PRECISE-TBI will be the Core Directors (Drs. Dixon, Gurkoff, VandeVord, Martone, LaPlaca, Harris, Floyd) and the Steering Committee Chair, Dr. Adam Ferguson. Leadership will interact with a Steering Committee (comprised of persons representing clinical expertise, other VA programs, other agencies, and all model types) to set objectives, milestones, and deliverables. We will have a Community Committee to be comprised of 100+ persons with wide TBI knowledge and perspectives. Committee members will be divided into task-oriented subcommittees, with oversight/guidance from Leadership and the Steering Committee. Core Directors, Steering Committee Chair, and the Steering Committee members are carefully selected to provide diversity and inclusion in TBI expertise, geographic location, funding history, gender identity, seniority, and research focus. Expertise in both acute and chronic TBI as well as pediatric TBI models will be included. Representatives from industry and non-profit organizations are included in the Steering Committee. The AO/Scientific Writer will compose drafts of documents for finalizing by Committee members. The organization structure of PRECISE-TBI connects investigators in both the Steering Committee and in the Community Committee which facilitates efficiency and wide-range engagement. Each of the Cores has an overarching objective that will be met by aims and milestones. The mission of the Administration Core is to promote effective and efficient communication and interactions between all elements of PRECISE-TBI. The working perspective is that the TBI investigators will act as both “employees” and “customers.” This dual role is because TBI investigators will be engaged to develop (employees) and use (customer) the consensus statements and translational roadmaps. The overarching goal of the Preclinical Model Catalogue Core is the creation, dissemination and maintenance of an online catalogue of preclinical models of TBI as well as create a database of preclinical TBI outcomes that are ontological to human TBI pathologies. The Common Data Elements Core mission is to develop and then benchmark new and existing common data elements using existing data from funded consortia and data from new endeavors. The Informatics Core seeks to fuel knowledge discovery through the development and implementation of a researcher-friendly infrastructure to support data sharing and implement standards and practices to make preclinical TBI data Findable, Accessible, Interoperable, and Reusable (FAIR). The mission of the Field TBI Program Coordination Core is to provide a bridge between the Center and the larger TBI community by leveraging existing infrastructure and growing the interactive community to use Center resources. Collectively, the Leadership, Steering Committee, Community Committee and Cores of PRECISE-TBI will support and accelerate the development of new candidate therapies for TBI.