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Chemistry Biology Interface Training Program

化学生物学界面培训计划

基本信息

批准号：
10620696
负责人：
Patrick G. Harran
金额：
$ 47.42万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10620696
关键词：
Biology Chemistry Training Programs

项目摘要

Project Summary The overall objective of the UCLA CBI Training Program is to educate a diverse group of scientists who will ethically lead rigorous research and training at the interface between chemistry and biology in the decades to come. Specifically, it is proposed that brilliant chemists who are amateurs in biology will be trained to identify and rigorously solve the most important problems in biology and be highly collaborative with biologists. Likewise, it is proposed that the biologist using a chemical technique as a black box will be converted into an expert who can identify new chemical approaches to solve their biological problems, and who are comfortable collaborating with chemists. The UCLA CBI Program provides this by breaking down the isolation between departments, and immersing trainees in state-of-the-art interdisciplinary research that spans the interface of chemistry and biology. The following specific aims are proposed: First, CBI will train graduate students in the language and techniques of research at the interface of chemistry and biology. Specifically, chemists will learn to be able to critically evaluate papers, be familiar with techniques and be able to rigorously discuss research topics in biology, and vice versa. Second, CBI will teach students the background to understand both the fundamentals and cutting edge research at the chemistry biology interface to enable them to distill this information in order to independently apply it to their own research and to develop new ideas. Third, CBI will enable students to hone their speaking skills and to work effectively in teams, especially with people in biology for chemists and vice versa. Fourth, the students will be instructed about ethical and responsible conduct of research so that they follow the ethical principals in their own research and hold these standards to others. Fifth, CBI trainees will be educated on the fundamentals of rigor and reproducibility in order to apply this to their own research and enable identification and interpretation of these factors in the work of others. Sixth and seventh, CBI will empower students to develop to their full potential professionally, providing them with all the tools necessary to make informed and successful career trajectory decisions and deliver additional mentoring and oversight on each trainee to enable them to graduate within the average time period for graduate students at UCLA. Eighth, CBI will provide an inclusive, supportive and diverse environment with approximately equal numbers of chemically and biologically oriented students, equal numbers of males and females, and 30% persons from underrepresented groups, as well as individuals with disabilities that have a strong identity as the UCLA CBI both as trainees and as alumni. To reach these aims a rigorous program of classes, training, and mentoring, coupled with recruitment and retention of persons from all groups and physical and learning abilities and a building of a strong UCLA CBI identity are proposed. An excellent team of world class faculty scholars is assembled who are also focused and serious about training and mentoring. UCLA provides extensive support and a large and diverse pool of excellent students to draw from to successfully reach these goals.

项目摘要加州大学洛杉矶分校CBI培训计划的总体目标是教育一个多元化的科学家群体，在几十年中，在化学和生物学之间的界面上进行严格的研究和培训，来了具体地说，它提出，在生物学方面业余的杰出化学家将被训练来识别严格解决生物学中最重要的问题，并与生物学家高度合作。同样，有人提议，使用化学技术作为黑盒的生物学家将被转换为专家谁可以确定新的化学方法来解决他们的生物问题，谁是舒适的，与化学家合作。加州大学洛杉矶分校的CBI计划通过打破部门，并沉浸在国家的最先进的跨学科研究，跨越接口的学员化学和生物学。提出了以下具体目标：第一，CBI将培养研究生在在化学和生物学的界面研究的语言和技术。具体来说，化学家将学习能够批判性地评估论文，熟悉技术，并能够严格地讨论研究生物学的主题，反之亦然。第二，CBI将教学生的背景，以了解双方的基础知识和前沿研究在化学生物学接口，使他们能够提取这一点，这些信息，以便独立地将其应用于自己的研究和开发新的想法。第三，CBI将使学生能够磨练他们的口语技能，并在团队中有效地工作，特别是与生物学方面的人对化学家来说，反之亦然。第四，学生将被教导道德和负责任的行为，研究，使他们遵循道德原则，在自己的研究和持有这些标准，以他人。第五，CBI学员将接受严格性和可重复性的基本教育，以便将其应用于他们自己的研究，并使这些因素的识别和解释，在其他人的工作。六和第第七，CBI将使学生能够在专业上充分发挥潜力，为他们提供所有提供必要的工具，以做出明智和成功的职业轨迹决定，并提供额外的指导并监督每个受训人员，使他们能够在研究生的平均时间内毕业在加州大学洛杉矶分校第八，CBI将提供一个包容、支持和多样化的环境，化学和生物方向的学生人数，男女人数相等，30% 代表性不足群体的人，以及残疾人，他们有强烈的认同感，加州大学洛杉矶分校加调局的实习生和校友。为了达到这些目标，我们制定了严格的课程、培训和指导，再加上招募和保留来自所有群体以及身体和学习能力的人员并提出了一个强大的加州大学洛杉矶分校CBI身份的建设。一个由世界一流的教师学者组成的优秀团队，他们也专注于并认真对待培训和指导。UCLA提供广泛的支持以及大量多元化的优秀学生可供选择，以成功实现这些目标。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure.

DOI：
10.1021/jacs.3c10179
发表时间：
2023-11-22
期刊：
Journal of the American Chemical Society
影响因子：
15
作者：
Yan C;Han W;Zhou Q;Niwa K;Tang MJ;Burch JE;Zhang Y;Delgadillo DA;Sun Z;Wu Z;Jacobsen SE;Nelson H;Houk KN;Tang Y
通讯作者：
Tang Y

Biosynthesis and synthetic biology of psychoactive natural products.