Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance

摘要 美国最近扩大了肺癌筛查计划，导致肺癌筛查人数显着增加 需要采样以评估其恶性状况的肺部病变数量。基于支气管镜 周围肺活检的手术并发症发生率最低。然而，诊断率已 仍然中等，主要是由于缺乏高分辨率、实时成像引导。技术如 支气管内超声和电磁导航支气管镜为治疗提供了一些指导 介入治疗，但对于活检针尖和病变的必要精细定位仍然有限 采样前。基于标准 CT 的成像方法对于内部检查而言过于昂贵且繁琐 程序使用。我们开发了一种基于固定式数字胸部断层合成成像方法 基于碳纳米管场发射源的线性X射线阵列。我们的方法提供了潜力 快速、高分辨率的面内成像与低剂量立体成像相结合，所有这些都不需要 X 射线源或探测器的任何物理运动。我们寻求改进固定式胸部断层合成 系统，评估快速 CT 到断层合成图像配准技术并集成软件控制 临床前大型动物评估系统中的指导系统。我们的学术与工业合作伙伴关系 将由物理学家、计算机科学家、放射科医生和介入肺科医生组成的团队组成 开发这个系统。

ABSTRACT The recent expansion of lung cancer screening programs in the United States has led to a significant increase in the number of lung lesions requiring sampling to evaluate their malignancy status. Bronchoscopic based peripheral lung biopsy offers the lowest rate of procedural complication. However, diagnostic yields have remained moderate, primarily due to the lack of high resolution, real-time imaging guidance. Techniques such as endobronchial ultrasound and electromagnetic navigational bronchoscopy offer some guidance for the interventionalist, but remain limited for the necessary fine localization of the biopsy needle tip and lesion just prior to sampling. Standard CT based imaging approaches are too expensive and cumbersome for intra- procedural use. We have developed a stationary digital chest tomosynthesis imaging approach based on the linear x-ray array based on the carbon nanotube field emission sources. Our approach offers the potential for rapid, high resolution in-plane imaging combined with low-dose stereoscopic imaging, all without the need for any physical motion of the x-ray source or detector. We seek to refine our stationary chest tomosynthesis system, evaluate rapid CT to tomosynthesis image registration techniques and integrate the software control and guidance system in a system for pre-clinical large animal evaluation. Our academic-industrial partnership will incorporate a team of physicists, computer scientists, radiologists and interventional pulmonologists to develop this system.