Arterial input function Independent Measures of Perfusion with Physics Driven Models
动脉输入功能 通过物理驱动模型独立测量灌注
基本信息
- 批准号:10688978
- 负责人:
- 金额:$ 20.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:Accident and Emergency departmentAccountingAcuteAffectAssimilationsBlood CirculationBlood flowBolus InfusionBrainCerebrovascular CirculationCerebrumClinicalClinical ManagementComputer softwareContrast MediaDataDecision MakingDependenceDevelopmentDiffusionEvaluationFDA approvedGoalsImageInfarctionInstitutionInterventionIntravenousIschemic PenumbraIschemic StrokeMagnetic Resonance ImagingMapsMeasurementMeasuresMechanicsMethodsModalityModelingMotionMovementNoisePathway interactionsPatient SelectionPatient TriagePatient-Focused OutcomesPatientsPerfusionPerfusion Weighted MRIPhysicsProcessRadiation exposureReperfusion TherapyRiskScanningSelection for TreatmentsShapesStrokeSystemTechniquesThrombectomyTimeTissuesTreatment ProtocolsUnited StatesX-Ray Computed Tomographybasecerebral blood volumeclinical predictorsclinically relevanteffective therapyfluid flowimprovedneuroimagingperfusion imagingpost strokespatial relationshipstroke outcomestroke patientstroke therapythrombolysis
项目摘要
ABSTRACT
Acute Ischemic Stroke (AIS) affects approximately 700,000 patients each year in the United States. [Benjamin
EJ 2019, Circulation] Though the introduction of intravenous thrombolytics improved patient outcomes, the
development of effective treatment regimens with mechanical thrombectomy has significantly altered the
clinical management of AIS patients, especially when appropriate patients are selected for intervention. The
current treatment selection approaches utilize patient specific data heavily relies on quantitative neuroimaging
approaches, derived from either Computer Tomography (CT), or to a lesser extent magnetic resonance
imaging (MRI). CT, with its relative availability within the US, has been the primary modality used for stroke
patient triage.
Brain perfusion imaging has been central to the evaluation of the ischemic penumbra and infarct core enabling
precision in patient selection for intra-arterial thrombolysis. Typically dynamic CT perfusion scans with
repeated scans 40 to 60 time points with the administration of iodinated contrast are obtained upon the arrival
in the emergency room. These images are automatically or semi-automatically post-processed into perfusion
metrics, using a number of FDA approved software packages. These packages all essentially rely on a similar
post-processing pathway for the dynamically acquired images, consisting of motion correction, arterial input
function selection and some form of deconvolution post-processing. A set of perfusion maps are generated,
typically including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time
to the maximum contrast concentration (Tmax). The software packages then apply thresholds to the CBF and
Tmax maps to generate a presumed ischemic “core” from the CBF and “penumbra” from the Tmax. However,
the dependence of these values on the arterial input function (AIF) selected has resulted in extensive efforts to
automate AIF selection, or explore systematic methods to produce local AIFs to improve perfusion
measurements. Defining a perfusion metric that is independent of AIF selection could substantially improve
stroke perfusion analysis, and reduce patient radiation exposure. The goal of this study is to evaluate a physics
based model of cerebral perfusion for evaluating perfusion parameters from CT perfusion modalities. The
critical requirements of the new technique include independence from AIF selection, quantitative and stable
measurements of perfusion that are clinically relevant and predictive of stroke outcomes.
摘要
急性缺血性卒中(AIS)在美国每年影响约70万患者。[本杰明
EJ 2019,循环]尽管静脉溶栓的引入改善了患者结局,
采用机械血栓切除术的有效治疗方案的发展显著改变了
AIS患者的临床管理,特别是在选择适当的患者进行干预时。的
目前的治疗选择方法利用患者特异性数据,
方法,来自计算机断层扫描(CT),或在较小程度上来自磁共振
成像(MRI)。CT在美国的相对可用性,一直是用于卒中的主要方式
病人分诊
脑灌注成像已成为评价缺血半暗带和梗死核心的核心,
动脉内溶栓患者选择的精确性。典型的动态CT灌注扫描,
在到达时获得40至60个时间点的重复扫描
在急诊室里。这些图像被自动或半自动地后处理成灌注
使用许多FDA批准的软件包。这些软件包基本上都依赖于一个类似的
动态采集图像的后处理路径,包括运动校正、动脉输入
函数选择和某种形式的反卷积后处理。生成一组灌注图,
典型地包括脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT)和时间
最大对比浓度(Tmax)。然后,软件包将阈值应用于CBF,
Tmax映射以从CBF生成假定的缺血性“核心”和从Tmax生成“半暗带”。然而,在这方面,
这些值对所选择的动脉输入函数(AIF)的依赖性导致了广泛的努力,
自动化AIF选择,或探索系统方法来产生局部AIF以改善灌注
测量.定义一个独立于AIF选择的灌注指标可以大大改善
中风灌注分析,并减少患者辐射暴露。这项研究的目的是评估一个物理
的脑灌注模型,用于评估CT灌注模式的灌注参数。的
新技术的关键要求包括独立于AIF选择,定量和稳定
灌注测量具有临床相关性并可预测卒中结局。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yueh Z Lee其他文献
Prospective cardiac gated stationary computed tomography enabled by carbon nanotube x-ray: a phantom study
由碳纳米管 X 射线实现的前瞻性心脏门控固定计算机断层扫描:一项模型研究
- DOI:
10.1117/12.3007040 - 发表时间:
2024 - 期刊:
- 影响因子:5.9
- 作者:
A. Billingsley;C. Inscoe;Yueh Z Lee - 通讯作者:
Yueh Z Lee
Dual-energy CBCT by spectral filtration of a dual-focus CNT x-ray source
通过双焦点 CNT X 射线源的光谱过滤进行双能 CBCT
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Boyuan Li;Yuanming Hu;C. Inscoe;Shuang Xu;Donald A. Tyndall;Yueh Z Lee;Jianping Lu;Otto Zhou - 通讯作者:
Otto Zhou
Yueh Z Lee的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yueh Z Lee', 18)}}的其他基金
Arterial input function Independent Measures of Perfusion with Physics Driven Models
动脉输入功能 通过物理驱动模型独立测量灌注
- 批准号:
10353761 - 财政年份:2021
- 资助金额:
$ 20.08万 - 项目类别:
Arterial input function Independent Measures of Perfusion with Physics Driven Models
动脉输入功能 通过物理驱动模型独立测量灌注
- 批准号:
10494211 - 财政年份:2021
- 资助金额:
$ 20.08万 - 项目类别:
Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance
用于经支气管活检指导的固定式数字断层合成
- 批准号:
10242668 - 财政年份:2019
- 资助金额:
$ 20.08万 - 项目类别:
Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance
用于经支气管活检指导的固定式数字断层合成
- 批准号:
9803015 - 财政年份:2019
- 资助金额:
$ 20.08万 - 项目类别:
Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance
用于经支气管活检指导的固定式数字断层合成
- 批准号:
10620615 - 财政年份:2019
- 资助金额:
$ 20.08万 - 项目类别:
Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance
用于经支气管活检指导的固定式数字断层合成
- 批准号:
10013194 - 财政年份:2019
- 资助金额:
$ 20.08万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 20.08万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 20.08万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 20.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 20.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 20.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 20.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 20.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 20.08万 - 项目类别:
Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 20.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 20.08万 - 项目类别: