Biomarker Core

马萨诸塞州阿尔茨海默病研究中心：生物标志物核心 马萨诸塞州阿尔茨海默病研究中心（MADRC）的生物标志物核心支持并 进行生物流体生物标志物研究，以帮助我们了解阿尔茨海默氏症的异质性 疾病和阿尔茨海默病相关疾病（AD/ADRD），并加速治疗进展。 我们执行核心职能，整合资源，通过目标1增强研究使命 MADRC血液和脑脊液（CSF）的采集、管理和分发活动， 国家研究和目标2的淀粉样蛋白的基本分子诊断测定的标准化性能， b42和tau有助于MADRC研究队列中AD/ADRD的生物学分类， 样品我们制定和实施新的战略，并加快实现目标3的治疗进展， 4对靶向多种病理生理学的新型ELISA、Simoa和MS测定的改进和验证 血液和CSF中的途径，以及Aim 5的表达重点是了解这些测定在临床和 临床试验设置。这些新方法在MADRC血液和CSF采集中进行了试点 跨越不同的AD/ADRD诊断、疾病阶段、预后、人口统计学（包括性别作为 生物学变量）、风险因素、异质性病理生理学驱动因素和治疗。成功的试点 工作和生物流体样本资源，然后利用，以促进更大的重点研究项目， 在MADRC社区之外。我们通过提供专业知识、教育和培训， 和实验室资源，以教师，学员和学生的最佳做法，在生物流体生物标志物的研究， 和目标7，通过向研究人员、临床医生和公众提供关于 负责任地解释ADRD研究中的生物标志物数据，以及最终如何将生物标志物用于 关注AD/ADRD患者。

Massachusetts Alzheimer’s Disease Research Center: Biomarker Core The Biomarker Core of the Massachusetts Alzheimer’s Disease Research Center (MADRC) supports and performs biofluid biomarker research to contribute to our understanding heterogeneity in Alzheimer’s disease and Alzheimer’s disease related disorders (AD/ADRD) and to accelerate progress towards a cure. We carry out core functions, marshaling resources to enhance the research mission through Aim 1's collection, curation and distribution activities for blood and cerebrospinal fluids (CSF) for MADRC, local and national research and Aim 2's standardized performance of essential molecular diagnostic assays of amyloid- b42 and tau to contribute to biological classification of AD/ADRDs in the MADRC Research Cohort and other samples. We develop and implement new strategies and accelerate progress towards a cure in Aim 3 and 4's refinement and validation of novel ELISA, Simoa, and MS assays targeting multiple pathophysiological pathways in blood and CSF, and in Aim 5's express focus on understanding those assays' utility for clinical and clinical trials settings. These novel approaches are piloted in the MADRC collections of blood and CSF spanning diverse AD/ADRD diagnoses, stages of disease, prognosis, demography (including sex as a biological variable), risk factors, heterogeneous pathophysiological drivers, and treatment. Successful pilot work and biofluid sample resources are then leveraged to facilitate larger focused research projects in and outside of the MADRC community. We build the future in Aim 6 by providing expertise, education, training and laboratory resources to faculty, trainees and students for best practices in biofluids biomarker research, and in Aim 7 by providing education to researchers, clinicians and the public on the advances, utility and responsible interpretation of biomarker data in ADRD research and ultimately how biomarkers can be used in caring for people with AD/ADRD.