Massachusetts Alzheimer's Disease Research Center

马萨诸塞州阿尔茨海默病研究中心

• 批准号: 10620661
• 负责人: BRADLEY T. HYMAN
• 金额: $ 330.67万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10620661
• 关键词: Acceleration; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid beta-Protein; Authorization documentation; Autopsy; Basic Science; Behavioral; Biological Assay; Biological Markers; Blood; Blood Vessels; Cerebrospinal Fluid; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Cognitive; Collaborations; Communities; Data; Data Linkages; Data Set; Dementia; Development; Diagnosis; Diagnostic Services; Disease; Education; Environment; Ethnic Origin; Event; Faculty; Faculty Recruitment; Fertilization; Frontotemporal Dementia; Frontotemporal Lobar Degenerations; Functional disorder; Future; General Hospitals; Goals; Heterogeneity; Image; Imaging Techniques; Impairment; Individual; Infrastructure; Institution; Knowledge; Laboratories; Leadership; Learning; Lesion; Lewy Body Disease; Link; MRI Scans; Massachusetts; Measures; Mentors; Methods; Mission; Molecular Profiling; Natural Immunity; Nerve Degeneration; Neurofibrillary Tangles; Neuropsychology; Participant; Pathology; Patients; Phenotype; Plasma; Play; Population Heterogeneity; Positron-Emission Tomography; Process; Prognosis; Race; Research; Research Methodology; Research Personnel; Research Support; Resources; Sampling; Science; Scientist; Statistical Data Interpretation; Structure; Techniques; Technology; Testing; Therapeutic Trials; Training; Training Programs; Update; Work; biomarker validation; clinical center; clinical phenotype; clinical training; cohort; community engagement; community setting; digital; disease heterogeneity; education research; follow-up; frontotemporal degeneration; imaging study; induced pluripotent stem cell; inflammatory marker; inter-individual variation; medical schools; mild cognitive impairment; multidisciplinary; neuroimaging; neuropathology; new technology; next generation; outreach; posters; programs; recruit; resilience; symposium; targeted biomarker; tau Proteins; therapeutic evaluation; therapeutic target; tool; validation studies

OVERVIEW: Massachusetts Alzheimer’s Disease Research Center (MADRC) The MADRC is an interdisciplinary Center at Massachusetts General Hospital, Harvard Medical School, with two major strategic goals: 1) to understand the underpinnings of heterogeneity of Alzheimer’s disease and Alzheimer’s Disease Related Disorders, and 2) to develop techniques, strategies, and technologies to accelerate a cure. To approach these goals, we propose 7 Cores (Administrative, Clinical, Biomarker, Imaging, Neuropathology, Data, and Outreach). We will use advanced Imaging, Biomarker, and analytic approaches to study our Research Cohort, which we view as a state of the art clinical phenotyping laboratory. Autopsy follow up for validation of biomarkers and imaging, and therapeutic targets, is essential. We plan to study a diverse population, both in the sense of various pathophysiologies, and also with varying racial and ethnic backgrounds, and rely on a vigorous ORE core both to fulfill our own recruitment needs and to support clinical trials and other affiliated programs. We have refocused our Center’s activities by remodeling the Research Cohort to include subjects who are cognitively normal, have mild cognitive impairment, or dementia, targeting diverse causes of dementia including Alzheimer’s disease and related disorders (Frontotemporal dementia, Lewy Body Disease, and vascular lesions). We postulate that heterogeneity of progression, even among individuals with the same “disease”, reflects underlying differences that can be uncovered, and that doing so will enhance clinical trial design by parsing variability from the very large, long cohort trials now in common use. Each Core is challenged to develop tools to help accelerate a cure – from intermediate imaging/biomarker targets that may help with diagnosis (a patient’s state) or prognosis (a patient’s fate), to performing autopsies to validate those targets. We will develop markers of inflammation and neurodegeneration, believing that innate immunity and resilience play a role in addition to tangles and plaques. Development of statistical and data methods are critical for anlaysis. These tools will allow us to test hypotheses about faster or slower rates of progression in a deeply phenotyped cohort. A final goal, central to our mission, is to build the future by training the next generation of scientists, which we propose to do under the framework of the Research Education Component. Together, we hope to make a difference in these devastating diseases.

概述：马萨诸塞州阿尔茨海默病研究中心 (MADRC) MADRC 是哈佛医学院马萨诸塞州总医院的一个跨学科中心， 两个主要战略目标：1）了解阿尔茨海默病异质性的基础和 阿尔茨海默氏病相关疾病，以及 2) 开发技术、策略和技术来 加速治愈。为了实现这些目标，我们提出了 7 个核心（管理、临床、生物标志物、 影像学、神经病理学、数据和外展）。我们将使用先进的成像、生物标记和分析 研究我们的研究队列的方法，我们将其视为最先进的临床表型实验室。 尸检随访对于生物标志物和成像以及治疗靶点的验证至关重要。我们计划 研究不同的人群，无论是在不同的病理生理学意义上，还是在不同的种族和群体中 种族背景，并依靠充满活力的 ORE 核心来满足我们自己的招聘需求并支持 临床试验和其他附属项目。 我们通过重塑研究队列来重新调整我们中心的活动重点，以纳入以下对象： 认知正常、有轻度认知障碍或痴呆，针对痴呆的多种原因 包括阿尔茨海默病和相关疾病（额颞叶痴呆、路易体病和 血管病变）。我们假设进展的异质性，即使在具有相同特征的个体之间也是如此 “疾病”，反映了可以发现的潜在差异，这样做将加强临床试验 通过分析目前常用的大型、长期队列试验的变异性来进行设计。 每个核心都面临着开发工具来帮助加速治愈的挑战——从中间成像/生物标志物 可能有助于诊断（患者的状态）或预后（患者的命运）的目标，以进行尸检 验证这些目标。我们将开发炎症和神经退行性变的标记物，相信 除了缠结和斑块之外，先天免疫和恢复力也发挥着作用。统计和发展 数据方法对于分析至关重要。这些工具将使我们能够测试有关更快或更慢速率的假设 深度表型队列中的进展。 我们使命的核心最终目标是通过培训下一代科学家来建设未来。 建议在研究教育部分的框架下进行。我们希望共同打造一个 这些毁灭性疾病的差异。