MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)

项目摘要 医生科学家通过识别在弥合基础科学和临床医生之间的差距发挥独特的作用 重要的临床问题和翻译结果，以改善病人护理。遗憾的是， 这可能会对生物医学研究产生负面的、长期的影响。许多居住地 课程主要侧重于获取医学知识，而不是培养求知欲和介绍 进入生物医学研究领域。进一步减少兴趣的职业生涯作为一个物理学家，科学家的能力， 确定一个令人鼓舞和成功的导师。有一个迫切需要重新强调既定的医生- 科学家作为学员的榜样。在这项建议中，我们的目的是提高吸引力和准备的职业生涯作为一个 实习期间的医生兼科学家阿尔茨海默病和相关痴呆（ADRD），虚弱， 老龄化中的多模态是科学的基本领域，极大地受益于强大的医生-科学家队伍。 在ADRD，虚弱，和多morphies在老龄化这一培训计划的总体目标是提高兴趣和准备 未来的医生，科学家，以解决人口老龄化所面临的问题，提供一个坚实的基础， 居民是富有成效的，独立的科学家，他们可以在从基础科学到 临床研究为此，我们建议实施马萨诸塞州综合医院疾病 老化途径通过刺激访问居住研究（MGH DAP StARR）计划。该计划将训练 新的医生，科学家在整个生物医学研究连续体谁将促进新的预防和治疗 与衰老有关的疾病的措施。MGH DAP StARR计划围绕以下四个目标：[1] 通过强有力的纵向指导，参与创造重要的科学贡献，重点是 领导要素; [2]开发必要的实验室，转化或临床研究方法，以进行高， 老龄化相关领域的质量研究; [3]制定基于假设的研究问题，开发和执行 一个研究项目，并有效地沟通他们的科学与来自NIA的强烈指导的意义- 资助的研究者;[4]建立一个途径，作为ADRD的独立医生-科学家继续发展， 脆弱和衰老的多重变化。MGH DAP StARR计划将允许两名来自医学系的居民 和神经学在MGH进行研究12-24个月在MGH或马库斯老龄化研究所在希伯来语 老年生活研究所。该计划将由克莉丝汀里奇（医学），布拉德利海曼（神经病学）， 和Jatin Vyas（医学住院医师项目主任），内部指导委员会和外部咨询委员会， 沿着的还有64位多学科和国家情报局资助的研究导师。这些举措旨在吸引， 培训，并保留医学博士在生物医学调查领域的ADRD，脆弱，和多morphine在老化 他们职业生涯中最关键的时刻住院医师培训。

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Regrettably, the physician-scientist workforce has continued to diminish, which may lead to negative, long-lasting consequences in biomedical research. Many residency programs focus heavily on acquiring medical knowledge as opposed to fostering intellectual curiosity and an introduction into the biomedical research field. Furthering the diminishing interest in a career as a physician-scientist is the ability to identify an encouraging and successful mentor. There is a critical need for a renewed emphasis on established physician- scientists as role models to trainees. In this proposal, we aim to enhance attractiveness and preparedness for a career as a physician-scientist during residency training. Alzheimer’s disease and related dementias (ADRD), frailty, and multimorbidity in aging are fundamental areas of science that greatly benefit from a robust physician-scientist workforce. The overall goal of this training program in ADRD, frailty, and multimorbidity in aging is to raise interest and preparedness of future physician-scientists to tackle the problems facing the aging population by providing a solid foundation to train residents to be productive, independent scientists who can advance studies in a broad range of areas from basic science to clinical investigation. To this end, we propose the implementation of the Massachusetts General Hospital Diseases of Aging Pathway via Stimulating Access to Research in Residency (MGH DAP StARR) program. The program will train new physician-scientists throughout the biomedical research continuum who will promote new preventative and therapeutic measures for aging-related diseases. The MGH DAP StARR program is centered around the following four objectives: [1] engage in the creation of important scientific contributions through strong, longitudinal mentorship with an emphasis on leadership essentials; [2] develop laboratory, translational, or clinical research approaches necessary to conduct high- quality research in pertinent areas of aging; [3] formulate hypothesis-based research questions, development and execution of a research project, and effectively communicate the significance of their science with intense mentorship from NIA- funded investigators; and [4] establish a pathway for continued development as independent physician-scientists in ADRD, frailty, and multimorbidity in aging. MGH DAP StARR program will allow two residents from the Departments of Medicine and Neurology at MGH to conduct research for 12-24 months at MGH or the Marcus Institute of Aging Research at Hebrew Senior Life Institute of Aging. The program will be co-led by Christine Ritchie (Medicine), Bradley Hyman (Neurology), and Jatin Vyas (Medicine Residency Program Director), an Internal Steering Committee, and External Advisory Board, along with 64 multidisciplinary and NIA-funded research preceptors. Together, these initiatives are designed to attract, train, and retain MDs in biomedical investigation in the areas of ADRD, frailty, and multimorbidity in aging at the most critical juncture of their career - residency training.