CTSA K12 Program at The Scripps Research Institute

项目总结/摘要 斯克里普斯研究翻译研究所（SRTI）的K12计划旨在提供和开发全面的翻译 科学能力和成功的翻译科学家的特点，推出毕业生进入研究 在学术机构、研究机构、生物技术公司、社区和公共卫生领域的职业生涯 计划和优先设置的政府机构。在斯克里普斯研究所，最大的私人，非营利生物医学 研究组织在美国，并与合作伙伴斯克里普斯健康，拉迪儿童基因组研究所 医学，和圣地亚哥州立大学（SDSU），我们将提供一个独特的和鼓舞人心的环境，为早期的职业生涯 生物医学研究人员应用我们的翻译科学方法优势，在设计和进行切割- 边缘翻译研究6名K12学者，在5年的培训中从临床研究员到初级教师不等 完成后，将获得2-4年的职业发展辅导，为每个人量身定制，以发现一个 研究利基和产生对个人赠款提交和研究独立性的初步结果。 我们将强调由跨学科顾问团队指导的研究活动，并由学术核心和试验协助 支持提供赠款管理、可行性评估、监管支持、社区参与咨询， 研究导航、无中心试验的远程入组平台、临床试验协调、电子健康记录数据 提取和研究整合、生物库收集和储存、广泛的湿实验室服务和数据分析。 由SRTI研究团队负责人创建和指导的转化科学课程将纳入道德和 可重复的研究实践，临床研究设计，有效沟通，granitarian，临床研究的社会背景 和转化研究，先进的分析，和精确的健康方法。有指导的体验式培训将 包括专业发展研讨会、跨学科团队合作、社区咨询委员会介绍， 学生指导，客座课程指导，以及SRTI在机构间合作和学术方面的代表 论坛。拟议的K12计划的目标是：1）增加2个翻译科学培训领域-数据 科学和人口健康-我们的基因组学，数字健康和社区参与的优势，利用 扩展的教师专业知识，新设计的课程，以及与Halıcıolu数据科学研究所的教育联盟 在加州圣地亚哥大学和SDSU的公共卫生学院; 2）推进多样性，公平和包容性（DEI） 通过指定的K12学者DEI联络员和SRTI的DEI协调课程、研究和体验式培训 主任;以及3）通过增加导师结构， 导师培训，新的专业发展活动，以及斯克里普斯医生科学家研究员计划作为桥梁 早期职业教师。K12计划的预期成果包括100%保留和指定学者的毕业， 90%的毕业生继续从事研究工作，增加了学者招聘的多样性，女性占50%，团体占20% 在科学中代表性不足，以及K12毕业生向新开发的医生科学家研究员轨道的过渡。

Project Summary/Abstract Scripps Research Translational Institute’s (SRTI’s) K12 Program aims to deliver and develop comprehensive translational science competencies and successful translational scientist characteristics that launch graduates into investigational careers within academic institutions, research institutes, biotechnology companies, community and public health programs, and priority-setting government agencies. Within Scripps Research, the largest private, non-profit biomedical research organization in the United States, and together with partners Scripps Health, Rady Children’s Institute of Genomic Medicine, and San Diego State University (SDSU), we will provide a unique and inspirational setting for early-career biomedical researchers applying our translational science methodology strengths in the design and conduct of cutting- edge translational research. Six K12 scholars, ranging in level from clinical fellows to junior faculty within 5 years of training completion, will be supported for 2-4 years of mentored career development tailored for each to discover an investigational niche and generate preliminary findings toward individual grant submission and research independence. We will emphasize research activities mentored by a cross-disciplinary advisor team, assisted by academic cores and trial support providing grant management, feasibility assessments, regulatory support, community engagement consultation, study navigation, remote enrollment platforms for site-less trials, clinical trial coordination, electronic health records data extraction and study integration, biorepository collection and storage, extensive wet lab services, and data analytics. Translational science coursework, created and directed by SRTI research team leaders, will incorporate ethical and reproducible research practices, clinical study design, effective communication, grantsmanship, social contexts of clinical and translational research, advanced analytics, and precision health methodologies. Mentored experiential training will include professional development seminars, transdisciplinary teamwork, community advisory board presentations, student mentorship, guest course instruction, and SRTI representation in inter-institutional collaborations and academic forums. Objectives for the proposed K12 Program are: 1) the addition of 2 translational science training domains – data science and population health – to our strengths of genomics, digital health, and community engagement, capitalizing on expanded faculty expertise, newly designed coursework, and educational alliances with Halıcıoğlu Data Science Institute at University of California San Diego and SDSU’s School of Public Health; 2) advancing diversity, equity, and inclusion (DEI) in curricula, research, and experiential training, coordinated through a nominated K12 Scholar DEI Liaison and SRTI’s DEI Director; and 3) increasing support for scholar transition to independence through added mentorship structure and mentor training, new professional development activities, and a Scripps Physician Scientist Fellows Program as a bridge for early career faculty. Intended K12 program outcomes include 100% retention and graduation of appointed scholars, 90% of graduates remaining in research careers, increased scholar recruit diversity to 50% women and 20% from groups underrepresented in science, and transition of a K12 graduate to a newly developed Physician Scientist Fellows track.