Institutional Career Development Core

摘要 斯克里普斯翻译科学研究所(STSI)的KL2职业发展计划旨在提供全面的临床- 未来生物医学领导者和研究人员在学术领域内规划职业生涯的转化研究能力 机构、医疗保健系统、社区/公共卫生方案、生物技术产业和确定优先事项的州 和联邦卫生机构。我们努力提供一个模范的、高度鼓舞人心的、创新的和培养人的环境 年轻的临床医生研究人员学习和练习独立研究的技能，促进学者的成功 通过广泛的实验室和临床研究选择，教授来自真实世界的经验和刺激的课程 作为多学科研究团队的一部分的参与性经验。我们项目的基本原理是创建 为斯克里普斯的学者提供全新的临床翻译研究机会、课程安排和参与式培训 研究机构(TSRI)和斯克里普斯健康(SH)在精准医学领域之前最低可在 斯克里普斯。自STSI成立以来，这些领域包括基因组学、生物信息学和社区参与，以及 已逐渐扩展到包括数字医学、药物发现、数据科学、 和行为健康。在STSI的KL2临床学者计划的支持下，创建了新的教育内容，并 教授临床试验设计、偏倚来源、生物统计学、计算生物学、不同领域的研究 人口，以及公私伙伴关系。KL2学者计划现在分享这一教育和研究培训 在TSRI研究生院和博士后机会以及SH的临床培训计划中广泛存在，同时 作为斯克里普斯研究和临床社区之间的合作桥梁。 KL2学者计划的主要活动包括：1)通过CLOSE提出、实施和报告原创研究 我们参与的教职员工之间的指导；2)旨在提供临床翻译的补充课程 科学奖界定的能力；以及3)提高科学交流技能的参与性培训， 团队合作、领导力和学术与行业合作。持续支持6个2-3年KL2职位， 临床-转译研究硕士学位的选择，初级教师或 博士后临床实习生，已经表现出对研究事业的强烈承诺。KL2计划 为学者提供多学科指导团队，帮助他们发展技能并通过以下方式找到研究利基 独立研究、课程作业、试点或其他种子资助的申请、初步研究数据的收集以及 这一出版物将成为独立资助的基础。 下一个周期的目标包括继续扩大现有的研究培训领域、创新教育 内容和交付，增加社区参与和外部活动的参与性体验，以及增加多样性 在我们的项目中，通过新的研究和招聘伙伴关系。

Abstract Scripps Translational Science Institute’s (STSI) KL2 career development program aims to deliver comprehensive clinical- translational research competencies to future biomedical leaders and investigators planning careers within academic institutions, healthcare systems, community/public health programs, the biotechnology industry, and priority-setting state and federal health agencies. We endeavor to provide an exemplary, highly inspirational, innovative, and nurturing setting in which young clinician investigators learn and practice skills toward research independence, promoting scholar success through extensive laboratory and clinical research options, classes taught from real-world experience, and stimulating participatory experiences as part of multidisciplinary research teams. The rationale for our program has been to create entirely new clinical-translational research opportunities, coursework, and participatory training for scholars at The Scripps Research Institute (TSRI) and Scripps Health (SH) within precision medicine domains previously minimally available at Scripps. Since STSI’s inception, these domains have included genomics, bioinformatics, and community engagement, and have gradually expanded to include important, new STSI concentrations in digital medicine, drug discovery, data science, and behavioral health. Bolstered by STSI’s KL2 clinical scholars program, new educational content has been created and taught by our faculty in clinical trial design, sources of bias, biostatistics, computational biology, research in diverse populations, and public-private partnerships. The KL2 scholars program now shares this education and research training widely throughout TSRI’s Graduate School and postdoctoral opportunities and within SH’s clinical training programs, while functioning as a collaborative bridge between Scripps’ research and clinical communities. Key activities in the KL2 scholar program include: 1) proposing, conducting, and reporting original research through close mentorship among our participating faculty; 2) complementary coursework designed to deliver Clinical Translational Science Award-delineated competencies; and 3) participatory training that increases skills in scientific communication, teamwork, leadership, and academic-industry collaboration. Six, 2-3 year KL2 positions are supported continuously, with an option for a Master’s in Clinical-Translational Investigation, and applications are invited from junior faculty or from postdoctoral clinical trainees who have demonstrated a strong prior commitment to a career in research. The KL2 program provides multidisciplinary mentorship teams for scholars as they develop skills and find a research niche through independent studies, coursework, applications for pilot or other seed grants, collection of preliminary research data, and publication that will form the basis for independent funding. Objectives for the next cycle include continued expansion of the available research training domains, innovative educational content and delivery, increased participatory experiences in community engagement and externships, and increased diversity in our program through new research and recruitment partnerships.