Investigating Mechanisms of Neurodegeneration

研究神经退行性变的机制

• 批准号: 10622321
• 负责人: Lauren O'Connor
• 金额: $ 3.49万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-09 至 2024-11-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10622321
• 关键词: Acute; Affect; Animal Feed; Animals; Axon; Axotomy; Bacteria; Bioinformatics; Biological Assay; Caenorhabditis elegans; Candidate Disease Gene; Chronic; Clinical; Comamonas; Data; Development; Diet; Disease; Environment; Escherichia coli; Fatty Acids; Future; Gene Expression; Genes; Genetic; Genome; Genotype; Goals; Homocysteine; Image; Impaired cognition; Injury; Institution; Lasers; Longevity; Mediating; Mentorship; Methionine; Methylmalonyl-CoA Mutase; Modeling; Molecular; Motor; Mus; Nematoda; Nerve Degeneration; Nervous System; Neurodegenerative Disorders; Neurons; Pathway interactions; Physiology; Play; Principal Investigator; Reproduction; Research; Role; Signal Transduction; Therapeutic; Tissues; Training; Vitamin B 12; axonal degeneration; candidate identification; clinical candidate; cofactor; effective therapy; experimental study; fly; genetic analysis; gut microbiota; gut-brain axis; human disease; in vivo; innovation; microbiome; motor neuron degeneration; mutant; neuroprotection; overexpression; prevent; programs; protective pathway; response; skills; therapeutic target

PROJECT SUMMARY Disease and injury cause a catastrophic loss of cognitive and motor abilities in the nervous system. Preventing neurodegeneration is critical to maintaining neuronal function. To develop effective treatments, we first need a greater understanding of the genetic and cellular mechanisms that determine whether the nervous system degenerates in response to various insults. Caenorhabditis elegans is a highly tractable model to dissect conserved molecular and cellular mechanisms. The goal of this proposal is to take advantage of the C. elegans model to identify regulatory mechanisms of axon degeneration. To reach this goal, I will apply my developing skills in detailed genetic analyses, laser axotomy, imaging, sequencing, and bioinformatics. The impact of this project is significant. In addition to providing a critical advance in understanding the fundamental mechanisms of neurodegeneration, it will also inform future therapeutic approaches that can be manipulated to protect the nervous system from degenerating.

项目摘要 疾病和损伤导致神经系统认知和运动能力的灾难性丧失。防止 神经变性对维持神经元功能至关重要。为了开发有效的治疗方法，我们首先需要 更好地理解决定神经系统是否 因各种侮辱而退化。秀丽隐杆线虫是一种非常易于解剖的模型， 保守的分子和细胞机制。该提案的目标是利用C。elegans 模型，以确定轴突变性的调节机制。为了达到这个目标，我将运用我的发展 详细的遗传分析，激光轴突切开术，成像，测序和生物信息学技能。这样做的影响 项目意义重大。除了在理解基本机制方面提供了重要的进展之外， 它还将为未来的治疗方法提供信息，这些方法可以被操纵来保护神经变性。 神经系统退化。