Administrative Core

核心A-总结/摘要 我们这项计划资助的最终目标是更好地了解肿瘤的异质性发病机制， AD及其如何受载脂蛋白（apo）E同种型的影响，使用人体组织，与 研究发现，在各种AD模型，使用蛋白质组学和其他方法，我们最近开发的。在 我们特别关注载脂蛋白E（apoE）亚型在以下方面发挥的不同作用：1）AD斑块， 血管淀粉样蛋白的发展（项目1）; 2）靶向Aβ/apoE相互作用的治疗方法（项目2） 2）; 3）对靶向异常构象的治疗性免疫调节的反应（项目3）。的 行政核心（核心A）负责确保本研究提案的成功。目标是： 目标1.提供行政结构和财政监督的计划项目赠款。 目标二。组织由项目和核心领导人组成的执行委员会（EC）的定期会议 和其他关键人员，以协助科学管理，并促进整合和继续 研究目标的进展。 目标3.与生物信息学/统计学/数据管理核心D协调，以确保最佳数据 项目的科学性和实用性。 目标4。与外部咨询委员会和内部咨询委员会密切互动，并定期 双方的会议。外部咨询委员会和内部咨询委员会将提供科学建议 并指导所有研究项目。 目标5。向NIH报告进展情况，并确保遵守NIH公共获取政策。 目标6。促进AD和相关疾病的教育，并促进P01科学家参与教育 研究人员、临床医生和患者/护理人员。

CORE A- SUMMARY/ABSTRACT Our ultimate goal of this program grant is to gain a better understanding of the heterogeneous pathogenesis of AD and how it is influenced by apolipoprotein (apo) E isotypes, using human tissue, with correlations to findings in various AD models, using proteomic and other methods which we have recently developed. In particular we are focusing on the differential role apolipoprotein E (apoE) isoforms play in: 1) AD plaque and vessel amyloid development (Project 1); 2) therapeutic approaches that target the Aβ/apoE interaction (Project 2); 3) responses to therapeutic immunomodulation targeting abnormal conformation (Project 3). The Administrative Core (Core A) is charged with ensuring the success of this research proposal. The Aims are: Aim 1. Provide administrative structure and fiscal oversight for the program project grant. Aim 2. Organize regular meetings of the Executive Committee (EC) composed of Project and Core Leaders and other key personnel to assist in scientific administration and to facilitate integration and continuing progress on research aims. Aim 3. Coordinate with the bioinformatics/statistical/data management Core D to ensure optimal data utilization and scientific rigor for the Program Project. Aim 4. Interact closely with the External Advisory Committee and Internal Advisory Board, and conduct regular meetings of both. The External Advisory Committee and Internal Advisory Board will provide scientific advice and guidance for all research projects. Aim 5. Report progress to NIH and ensure compliance with the NIH Public Access policy. Aim 6. Promote education on AD and related disorders, and facilitate P01 scientists’ participation in education to researchers, clinicians and patients/caregivers.