An Anticoagulation-Free Artificial Placenta Device

一种免抗凝人工胎盘装置

基本信息

  • 批准号:
    10741704
  • 负责人:
  • 金额:
    $ 46.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Extremely preterm (EPT) infants have a high rate of mortality and morbidity, primarily due to the underdevelopment of the lungs. When born before 23 weeks of gestation, infants are generally considered non- viable, and have no options to keep them alive. Between 23-27 weeks, these infants still have high morbidity and mortality, with survival to discharge without major morbidity varying between 43% at 27 weeks to 2% at 23 weeks. An artificial placenta is an adaptation of extracorporeal membrane oxygenation (ECMO) designed for a premature infant and performs extracorporeal gas exchange. An artificial placenta simulates intrauterine physiology and may enable continued normal development outside of the uterus. However, current artificial placenta oxygenators in development use hollow-fiber membrane (HFM) technology, which is limited by high- dose anticoagulation requirements and large priming volumes. Anticoagulation is especially dangerous in EPT infants, who already have high rates of intracranial hemorrhage due to their underdeveloped cerebral vasculature. The SiMOx-AP is a novel microfluidic artificial placenta oxygenator designed to operate without anticoagulation, thus overcoming a key barrier to clinical translation of an artificial placenta device. It is based on breakthrough semiconductor silicon-based semi-permeable membranes made using microfabrication techniques. The rigid and flat-plate nature of the silicon membranes overcome limitations of HFM and flexible microfluidic oxygenators. In this R21, we will investigate the feasibility of a clinical-scale and anticoagulation-free SiMOx-AP device using a combination of computational, benchtop, and preclinical in-vivo studies.
项目总结/文摘

项目成果

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SHUVO ROY其他文献

SHUVO ROY的其他文献

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{{ truncateString('SHUVO ROY', 18)}}的其他基金

Implantable Bio-Artificial Pancreas (iBAP)
植入式生物人工胰腺 (iBAP)
  • 批准号:
    9752544
  • 财政年份:
    2017
  • 资助金额:
    $ 46.18万
  • 项目类别:
Implantable Bio-Artificial Pancreas (iBAP)
植入式生物人工胰腺 (iBAP)
  • 批准号:
    9418357
  • 财政年份:
    2017
  • 资助金额:
    $ 46.18万
  • 项目类别:
Implantable Bio-Artificial Pancreas (iBAP)
植入式生物人工胰腺 (iBAP)
  • 批准号:
    10186950
  • 财政年份:
    2017
  • 资助金额:
    $ 46.18万
  • 项目类别:
Biocompatibility of Implantable Renal Replacement Devices
植入式肾脏替代装置的生物相容性
  • 批准号:
    8296151
  • 财政年份:
    2012
  • 资助金额:
    $ 46.18万
  • 项目类别:
Biocompatibility of Implantable Renal Replacement Devices
植入式肾脏替代装置的生物相容性
  • 批准号:
    8463847
  • 财政年份:
    2012
  • 资助金额:
    $ 46.18万
  • 项目类别:
Biocompatibility of Implantable Renal Replacement Devices
植入式肾脏替代装置的生物相容性
  • 批准号:
    8658431
  • 财政年份:
    2012
  • 资助金额:
    $ 46.18万
  • 项目类别:
Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy
用于全肾脏替代治疗的微型植入式肾脏辅助装置
  • 批准号:
    7681240
  • 财政年份:
    2007
  • 资助金额:
    $ 46.18万
  • 项目类别:
Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy
用于全肾脏替代治疗的微型植入式肾脏辅助装置
  • 批准号:
    7343505
  • 财政年份:
    2007
  • 资助金额:
    $ 46.18万
  • 项目类别:
Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy
用于全肾脏替代治疗的微型植入式肾脏辅助装置
  • 批准号:
    7499663
  • 财政年份:
    2007
  • 资助金额:
    $ 46.18万
  • 项目类别:
Microneedle Array for Catheter Drug Delivery
用于导管药物输送的微针阵列
  • 批准号:
    6734397
  • 财政年份:
    2003
  • 资助金额:
    $ 46.18万
  • 项目类别:

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