Implantable Bio-Artificial Pancreas (iBAP)

植入式生物人工胰腺 (iBAP)

• 批准号: 10186950
• 负责人: SHUVO ROY
• 金额: $ 80.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10186950
• 关键词: Adult Respiratory Distress Syndrome; Animal Testing; Anticoagulation; Attention; Blood; Blood Pressure; Blood flow; Bypass; COVID-19; COVID-19 patient; Caring; Cell Membrane Permeability; Cessation of life; China; Clinical; Coagulation Process; Country; Critical Illness; Data; Development; Devices; Exhibits; Extracorporeal Membrane Oxygenation; FDA Emergency Use Authorization; FDA approved; Family suidae; Femoral vein; Filtration; Gases; Heart; Hemorrhage; Hospitals; Human Resources; Insulin; Italy; Kidney; Liquid substance; Lung; Maps; Mechanical Ventilators; Mechanical ventilation; Medical center; Membrane; Membrane Oxygenators; Modification; New York; Oxygen; Oxygenators; Pancreas; Pathway interactions; Patients; Permeability; Polyethylene Glycols; Procedures; Production; Ramp; Resistance; Risk; Safety; Secondary to; Side; Silicon; Sterilization; System; Techniques; Technology; Testing; Ventilator-induced lung injury; Work; biomaterial compatibility; blood filtration; commercialization; design; experience; femoral artery; first-in-human; nanopore; operation; pressure; prototype; respiratory; respiratory gas; simulation

PROJECT SUMMARY/ABSTRACT As of May 25th, 2020, there were over 5.5 million confirmed cases of COVID-19 worldwide and around 1.7 million in the US, where almost 100,000 deaths have occurred. Acute Respiratory Distress Syndrome (ARDS) presents secondary to COVID-19 and is primarily treated by mechanical ventilation. Of all hospitalized COVID- 19 patients, around 20% will be intubated and mechanically ventilated. Unfortunately, ARDS patients are especially susceptible to ventilator induced lung injury (VILI) and as many as 80% of intubated COVID-19 patients have died. In contrast, ECMO bypasses the lungs, thereby avoiding VILI, and the patient’s blood is directly oxygenated using an extracorporeal circuit containing a gas-permeable membrane. While ECMO has shown increased survival relative to mechanical ventilation, the complexity of the ECMO procedure, associated bleeding and clotting risks, and labor intensiveness has restricted its use. We propose to develop a new oxygenator membrane constructed from silicon nanopore membranes (SNM). The enhanced biocompatibility and increased gas flux of the SNM will enable the Silicon Membrane Oxygenator (SiMOx) - a compact and potentially anticoagulation-free ECMO system. The SiMOx will establish a new paradigm of “set it and forget it” blood oxygenation that is characterized by decreased operational complexity, diminished bleeding/clotting risks, and reduced personnel needs.

项目概要/摘要 截至 2020 年 5 月 25 日，全球已确诊超过 550 万例 COVID-19 病例，约 1.7 例 美国已造成近 10 万人死亡。急性呼吸窘迫综合征（ARDS） 继发于 COVID-19，主要通过机械通气治疗。在所有住院的新冠肺炎患者中 19 名患者中，约 20% 将接受插管和机械通气。不幸的是，ARDS 患者 特别容易受到呼吸机诱发性肺损伤 (VILI) 和多达 80% 的插管性 COVID-19 的影响 患者已经死亡。相比之下，ECMO绕过肺部，从而避免了VILI，患者的血液是 使用含有透气膜的体外回路直接充氧。虽然 ECMO 有 结果表明，相对于机械通气，ECMO 程序的复杂性、相关的生存率有所提高。 出血和凝血风险以及劳动强度限制了其使用。我们建议开发一个新的 由硅纳米孔膜（SNM）构建的氧合器膜。增强的生物相容性 SNM 的气体通量增加将使硅膜氧合器 (SiMOx) 成为可能，这是一种紧凑且 潜在的免抗凝 ECMO 系统。 SiMOx 将建立“设置后忘记它”的新范式 血液氧合的特点是操作复杂性降低、出血/凝血减少 风险，并减少人员需求。

项目成果

Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications.

用于封装成人胰岛和人类干细胞衍生的 β 细胞的超孔琼脂糖支架，用于血管内生物人工胰腺应用。

• DOI: 10.1002/jbm.a.37236
• 发表时间: 2021
• 期刊: Journal of biomedical materials research. Part A
• 作者: Shaheen,Rebecca;Gurlin,RachelE;Gologorsky,Rebecca;Blaha,Charles;Munnangi,Pujita;Santandreu,Ana;Torres,Alonso;Carnese,Phichitpol;Nair,GopikaG;Szot,Gregory;Fissell,WilliamH;Hebrok,Matthias;Roy,Shuvo
• 通讯作者: Roy,Shuvo