Implantable Bio-Artificial Pancreas (iBAP)

植入式生物人工胰腺 (iBAP)

• 批准号: 10186950
• 负责人: SHUVO ROY
• 金额: $ 80.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10186950
• 关键词: Adult Respiratory Distress Syndrome; Animal Testing; Anticoagulation; Attention; Blood; Blood Pressure; Blood flow; Bypass; COVID-19; COVID-19 patient; Caring; Cell Membrane Permeability; Cessation of life; China; Clinical; Coagulation Process; Country; Critical Illness; Data; Development; Devices; Exhibits; Extracorporeal Membrane Oxygenation; FDA Emergency Use Authorization; FDA approved; Family suidae; Femoral vein; Filtration; Gases; Heart; Hemorrhage; Hospitals; Human Resources; Insulin; Italy; Kidney; Liquid substance; Lung; Maps; Mechanical Ventilators; Mechanical ventilation; Medical center; Membrane; Membrane Oxygenators; Modification; New York; Oxygen; Oxygenators; Pancreas; Pathway interactions; Patients; Permeability; Polyethylene Glycols; Procedures; Production; Ramp; Resistance; Risk; Safety; Secondary to; Side; Silicon; Sterilization; System; Techniques; Technology; Testing; Ventilator-induced lung injury; Work; biomaterial compatibility; blood filtration; commercialization; design; experience; femoral artery; first-in-human; nanopore; operation; pressure; prototype; respiratory; respiratory gas; simulation

PROJECT SUMMARY/ABSTRACT As of May 25th, 2020, there were over 5.5 million confirmed cases of COVID-19 worldwide and around 1.7 million in the US, where almost 100,000 deaths have occurred. Acute Respiratory Distress Syndrome (ARDS) presents secondary to COVID-19 and is primarily treated by mechanical ventilation. Of all hospitalized COVID- 19 patients, around 20% will be intubated and mechanically ventilated. Unfortunately, ARDS patients are especially susceptible to ventilator induced lung injury (VILI) and as many as 80% of intubated COVID-19 patients have died. In contrast, ECMO bypasses the lungs, thereby avoiding VILI, and the patient’s blood is directly oxygenated using an extracorporeal circuit containing a gas-permeable membrane. While ECMO has shown increased survival relative to mechanical ventilation, the complexity of the ECMO procedure, associated bleeding and clotting risks, and labor intensiveness has restricted its use. We propose to develop a new oxygenator membrane constructed from silicon nanopore membranes (SNM). The enhanced biocompatibility and increased gas flux of the SNM will enable the Silicon Membrane Oxygenator (SiMOx) - a compact and potentially anticoagulation-free ECMO system. The SiMOx will establish a new paradigm of “set it and forget it” blood oxygenation that is characterized by decreased operational complexity, diminished bleeding/clotting risks, and reduced personnel needs.

项目总结/摘要 截至2020年5月25日，全球有超过550万例COVID-19确诊病例，约1. 7 在美国，有近10万人死亡。急性呼吸窘迫综合征（ARDS） 继发于COVID-19，主要通过机械通气治疗。在所有住院的COVID- 19名患者，约20%将接受插管和机械通气。不幸的是，ARDS患者 特别容易受到呼吸机诱导的肺损伤（VILI）和多达80%的插管COVID-19 病人已经死亡。相比之下，ECMO绕过肺部，从而避免VILI，并且患者的血液 使用含有透气膜的体外回路直接充氧。虽然ECMO 与机械通气相比，ECMO手术的复杂性， 出血和凝血的风险，以及劳动强度限制了它的使用。我们建议开发一种新的 氧合器膜由硅纳米孔膜（SNM）构成。增强的生物相容性 和SNM的增加的气体通量将使硅膜氧合器（SiMOx）-一种紧凑且 可能无抗凝剂的ECMO系统SiMOx将建立一个“设置它并忘记它”的新范式 血液氧合的特点是降低操作复杂性，减少出血/凝血 降低风险，减少人员需求。

项目成果

Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications.

用于封装成人胰岛和人类干细胞衍生的 β 细胞的超孔琼脂糖支架，用于血管内生物人工胰腺应用。

• DOI: 10.1002/jbm.a.37236
• 发表时间: 2021
• 期刊: Journal of biomedical materials research. Part A
• 作者: Shaheen,Rebecca;Gurlin,RachelE;Gologorsky,Rebecca;Blaha,Charles;Munnangi,Pujita;Santandreu,Ana;Torres,Alonso;Carnese,Phichitpol;Nair,GopikaG;Szot,Gregory;Fissell,WilliamH;Hebrok,Matthias;Roy,Shuvo
• 通讯作者: Roy,Shuvo