Implantable Bio-Artificial Pancreas (iBAP)

植入式生物人工胰腺 (iBAP)

• 批准号: 10186950
• 负责人: SHUVO ROY
• 金额: $ 80.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10186950
• 关键词: Adult Respiratory Distress Syndrome; Animal Testing; Anticoagulation; Attention; Blood; Blood Pressure; Blood flow; Bypass; COVID-19; COVID-19 patient; Caring; Cell Membrane Permeability; Cessation of life; China; Clinical; Coagulation Process; Country; Critical Illness; Data; Development; Devices; Exhibits; Extracorporeal Membrane Oxygenation; FDA Emergency Use Authorization; FDA approved; Family suidae; Femoral vein; Filtration; Gases; Heart; Hemorrhage; Hospitals; Human Resources; Insulin; Italy; Kidney; Liquid substance; Lung; Maps; Mechanical Ventilators; Mechanical ventilation; Medical center; Membrane; Membrane Oxygenators; Modification; New York; Oxygen; Oxygenators; Pancreas; Pathway interactions; Patients; Permeability; Polyethylene Glycols; Procedures; Production; Ramp; Resistance; Risk; Safety; Secondary to; Side; Silicon; Sterilization; System; Techniques; Technology; Testing; Ventilator-induced lung injury; Work; biomaterial compatibility; blood filtration; commercialization; design; experience; femoral artery; first-in-human; nanopore; operation; pressure; prototype; respiratory; respiratory gas; simulation

PROJECT SUMMARY/ABSTRACT As of May 25th, 2020, there were over 5.5 million confirmed cases of COVID-19 worldwide and around 1.7 million in the US, where almost 100,000 deaths have occurred. Acute Respiratory Distress Syndrome (ARDS) presents secondary to COVID-19 and is primarily treated by mechanical ventilation. Of all hospitalized COVID- 19 patients, around 20% will be intubated and mechanically ventilated. Unfortunately, ARDS patients are especially susceptible to ventilator induced lung injury (VILI) and as many as 80% of intubated COVID-19 patients have died. In contrast, ECMO bypasses the lungs, thereby avoiding VILI, and the patient’s blood is directly oxygenated using an extracorporeal circuit containing a gas-permeable membrane. While ECMO has shown increased survival relative to mechanical ventilation, the complexity of the ECMO procedure, associated bleeding and clotting risks, and labor intensiveness has restricted its use. We propose to develop a new oxygenator membrane constructed from silicon nanopore membranes (SNM). The enhanced biocompatibility and increased gas flux of the SNM will enable the Silicon Membrane Oxygenator (SiMOx) - a compact and potentially anticoagulation-free ECMO system. The SiMOx will establish a new paradigm of “set it and forget it” blood oxygenation that is characterized by decreased operational complexity, diminished bleeding/clotting risks, and reduced personnel needs.

项目摘要/摘要 截至2020年5月25日，全世界有超过550万例COVID案件，约1.7案。 在美国，发生了近100,000人死亡。急性呼吸窘迫综合征（ARDS） 呈现后期是Covid-19，主要通过机械通气处理。所有住院的covid- 19例患者将插管并进行机械通风。不幸的是，ARDS患者是 特别容易受到呼吸机诱导的肺损伤（VILI），多达80％的插管Covid-19 患者死了。相比之下，ECMO绕过肺，从而避免了Vili，患者的血液是 使用含有气体渗透膜的体外电路直接氧合。而ecmo拥有 显示出相对于机械通气的生存率增加，ECMO程序的复杂性，相关 出血和关闭风险以及劳动力强度限制了其使用。我们建议开发一个新的 由硅纳米孔膜（SNM）构建的氧合膜。增强的生物相容性 SNM的气体通量增加将使硅膜氧合（Simox） - 紧凑和 潜在的无抗凝ECMO系统。 Simox将建立“设置并忘记它”的新范式 血液氧合的特征是操作复杂性降低，出血/凝结减少 风险和减少人员需求。

项目成果

Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications.

用于封装成人胰岛和人类干细胞衍生的 β 细胞的超孔琼脂糖支架，用于血管内生物人工胰腺应用。

• DOI: 10.1002/jbm.a.37236
• 发表时间: 2021
• 期刊: Journal of biomedical materials research. Part A
• 作者: Shaheen,Rebecca;Gurlin,RachelE;Gologorsky,Rebecca;Blaha,Charles;Munnangi,Pujita;Santandreu,Ana;Torres,Alonso;Carnese,Phichitpol;Nair,GopikaG;Szot,Gregory;Fissell,WilliamH;Hebrok,Matthias;Roy,Shuvo
• 通讯作者: Roy,Shuvo