ShEEP Request for Bruker BioSpec 3T MRI System Upgrade

ShEEP 请求布鲁克 BioSpec 3T MRI 系统升级

• 批准号: 10740786
• 负责人: Eric Y Chang
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10740786
• 关键词: Acceleration; Amplifiers; Anatomy; Animals; Beds; Behavioral Research; Biomedical Engineering; Cardiac; Cardiology; Caregivers; Caring; Clinic; Communities; Complex; Core Facility; Degenerative polyarthritis; Detection; Disease; Endocrinology; Floor; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Gastroenterology; Healthcare; Healthcare Systems; Image; Imaging Techniques; Injury; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Medical Research; Medical center; Mission; Modality; Morphology; Mus; Muscle function; Nerve Degeneration; Neurology; Noise; Oncology; Operative Surgical Procedures; Organ; Orthopedics; Patients; Performance; Phase; Pre-Clinical Model; Productivity; Protons; Psychiatry; Pulmonology; Radiology Specialty; Renal function; Research; Research Personnel; Resolution; Rodent; Sampling; Scanning; Services; Sheep; Signal Transduction; Sodium; Stroke; System; Time; Translational Research; United States Department of Veterans Affairs; Veterans; Water; bench-to-bedside translation; blood oxygen level dependent; brain magnetic resonance imaging; clinical care; cost; cryogenics; data acquisition; experimental study; field study; imaging capabilities; imaging system; improved; in vivo; neuroimaging; neuroinflammation; nuclear imaging; pre-clinical; pre-clinical research; radio frequency

The capability of performing longitudinal magnetic resonance imaging (MRI) on small animals in vivo significantly and positively impacts a large number of VA-supported projects in basic, translational and preclinical biomedical/behavioral research relevant to Veteran's healthcare currently conducted at the Jennifer Moreno VA Medical Center (JMVAMC) (formerly known as the VA San Diego Healthcare System). We have a Bruker BioSpec 3T small animal MRI system which is integrated into the centralized JMVAMC/Veterans Medical Research Foundation Microimaging Core facility, but the current configuration is limited in its ability to perform rapid scans, including the inability to perform high-quality mouse cardiac and mouse functional brain MRI experiments. We are a group of 18 investigators with active VA funding who will directly benefit from upgrading the existing Bruker BioSpec 3T MRI system. Our projects which will benefit from the upgrades encompass a wide range of fields and research, including radiology, cardiology, orthopaedics, bioengineering, neurology, psychiatry, pulmonology, endocrinology, gastroenterology, oncology, and surgery. Upgrading our small animal MRI imaging system to the latest state-of-the-art system will not only impact basic pre-clinical research at JMVAMC, but is also expected to have a strong and positive effect through improvement of patient clinical care. The imaging techniques employed on our 3T system are readily incorporated to the clinic, ultimately supporting the VA healthcare mission.

在活体动物身上进行纵向磁共振成像(MRI)的能力显著 并对退伍军人管理局在基础、转换和临床前支持的大量项目产生积极影响 与退伍军人医疗保健相关的生物医学/行为研究目前在詹妮弗·莫雷诺进行 退伍军人医疗中心(JMVAMC)(前身为退伍军人事务部圣地亚哥医疗系统)。我们有一个叫布鲁克的 集成到JMVAMC/退伍军人医疗中心的BioSpec 3T小动物磁共振系统 Research Foundation微成像核心设施，但当前配置在其执行能力方面受到限制 快速扫描，包括无法执行高质量的小鼠心脏和小鼠功能性脑MRI 实验。我们是一个由18名调查人员组成的小组，他们拥有活跃的退伍军人管理局资金，将直接受益于升级 现有的Bruker BioSpec 3T核磁共振系统。我们将从升级中受益的项目包括 广泛的领域和研究，包括放射学、心脏病学、骨科、生物工程、神经学、 精神病学、肺病学、内分泌学、胃肠病学、肿瘤学和外科。升级我们的小动物 MRI成像系统到最先进的系统不仅将影响基础临床前研究 JMVAMC，但也有望通过改善患者的临床护理产生强大和积极的效果。 我们的3T系统上采用的成像技术很容易被整合到临床上，最终支持 退伍军人事务部的医疗保健任务。