Predicting fatal and non-fatal overdose in Los Angeles County with Rapid Overdose Surveillance Dashboard to target street-based addiction treatment and harm reduction services

利用快速过量用药监测仪表板预测洛杉矶县的致命和非致命用药过量，以针对街头成瘾治疗和减少伤害服务

• 批准号: 10741388
• 负责人: David Goodman
• 金额: $ 21.42万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-29 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10741388
• 关键词: Alaska Native; Algorithms; American Indians; Asian; Award; Behavioral; Black Populations; Black race; Bupropion; California; Caring; Cessation of life; Chronic Disease; Classification; Cocaine; Code; Collaborations; County; Data; Data Analyses; Data Sources; Development; Doctor of Philosophy; Electronic Health Record; Emergency department visit; Epidemiologist; Ethnic Origin; Exclusion; Fentanyl; Funding; General Population; Goals; Harm Reduction; Health; Health Services; Healthcare; Helping to End Addiction Long-term; Hispanic; Hospitalization; Illicit Drugs; Individual; International Classification of Disease Codes; International Classification of Diseases; Intervention; K-Series Research Career Programs; Latino; Latinx; Licensing; Los Angeles; Machine Learning; Medical; Medicine; Mental Health Services; Mentors; Mentorship; Methadone; Methamphetamine; Mirtazapine; Naltrexone; National Institute of Drug Abuse; Native Americans; Native-Born; Natural Language Processing; Not Hispanic or Latino; Opioid; Outcome; Overdose; Patient Care; Patients; Persons; Pharmaceutical Preparations; Physicians; Population; Prevention; Provider; Psychologist; Public Health; Race; Receiver Operating Characteristics; Records; Research; Research Design; Research Personnel; Research Project Grants; Science; Scientist; Services; Stimulant; Substance Use Disorder; System; Text; Time; Training; Translating; United States National Institutes of Health; United States Public Health Service; Writing; addiction; analog; care systems; contingency management; dashboard; design; ethnic diversity; examination questions; experience; health assessment; health care model; health care service; health care service utilization; health difference; improved; mortality; neighborhood disadvantage; opioid use; opioid use disorder; outreach; overdose death; parent grant; patient population; polysubstance use; primary care visit; racial diversity; skills; stimulant use; stimulant use disorder; substance use treatment; synthetic opioid; tool

PROJECT SUMMARY This Diversity Supplement is designed to support and enhance the diversity of the health-related research workforce through the training of Sarah Clingan, PhD., a Latinx/Native American Addiction Researcher. The supplement is complementary to the parent grant, an R01 on overdose and opioid use disorder in Los Angeles County, funded under the National Institutes of Health's Helping End Addiction Long-Term Initiative. Dr. Clingan has a strong research background in addiction sciences that will continue to develop under the mentorship of Dr. Chelsea Shover (primary mentor, epidemiologist, and MPI of parent grant), Dr. Steve Shoptaw (senior co-mentor) a licensed psychologist and Director of the Center for Behavioral and Addiction Medicine at UCLA, and Dr. David Goodman-Meza (co-mentor, physician-scientist, and MPI of parent grant). These three mentors have a strong record of collaboration and a track record of mentoring underrepresented scholars. Through this supplement, Dr. Clingan will obtain training and mentorship across three training objectives. The first will focus on gaining skills and experience using natural language processing (NLP) and machine learning approaches. She will additionally gain skills in designing research projects using real-world data to study polysubstance use. Her third and final training objective is professional development activities that will culminate in her writing a K01 career development award, using the findings generated by the Diversity Supplement as pilot data. The research component of the Diversity Supplement will use electronic health record (EHR) data collected via the parent grant to identify people with polysubstance use and create models of healthcare utilization among those who co-use opioids and stimulants. Specifically, the aims of the Diversity Supplement research plan are to: 1) develop an algorithm to identify people with polysubstance use (opioids and stimulants) in EHR data; 2) Characterize healthcare utilization among those who co-use opioids and stimulants using NLP-based approaches. These results will improve our understanding of polysubstance use in a county with a very high burden of overdose involving fentanyl and stimulants, and contribute to our understanding of the gaps in healthcare services for this population in Los Angeles County. The Diversity Supplement findings will also provide preliminary data for Dr. Clingan's planned K01 application. This award will provide Dr. Clingan with the support, mentorship, and protected time that will enhance her training at UCLA and facilitate her transition to become an independent researcher.

项目摘要 该多样性补充旨在支持和加强与健康相关的研究的多样性 通过Sarah Clingan博士的培训，拉丁裔/美洲原住民成瘾研究员的 补充金是对父母补助金的补充，这是针对洛杉矶吸毒过量和阿片类药物使用障碍的R 01 县，根据美国国立卫生研究院的帮助结束成瘾长期倡议资助。博士 Clingan在成瘾科学方面有很强的研究背景，这将在未来继续发展。 Chelsea Shover博士（主要导师，流行病学家和父母补助金的MPI），Steve博士 Shoptaw（高级共同导师），持牌心理学家，行为和成瘾中心主任 医学在加州大学洛杉矶分校，和博士大卫古德曼梅扎（共同导师，医生，科学家，和MPI的父母补助金）。 这三位导师有着良好的合作记录和指导不足的记录 学者通过这一补充，Clingan博士将获得三个培训项目的培训和指导 目标.第一个将侧重于获得使用自然语言处理（NLP）的技能和经验， 机器学习方法。她还将获得使用真实世界设计研究项目的技能 研究多物质使用的数据。她的第三个也是最后一个培训目标是专业发展活动 这将最终在她写K 01职业发展奖，使用的结果产生的多样性 作为试点数据补充。多样性补充的研究部分将使用电子健康 通过母基金收集的电子健康记录（EHR）数据，以识别使用多种物质的人并创建模型 同时使用阿片类药物和兴奋剂的人的医疗保健利用率。具体而言，多样性的目标 补充研究计划是：1）开发一种算法来识别使用多种物质（阿片类药物）的人 和兴奋剂）; 2）描述共同使用阿片类药物的人的医疗保健利用情况， 使用基于NLP的方法的兴奋剂。这些结果将提高我们对多物质使用的理解， 一个县与涉及芬太尼和兴奋剂过量的负担非常高，并有助于我们的 了解洛杉矶县这一人群的医疗保健服务差距。之多样 补充调查结果还将为Clingan博士计划的K 01应用提供初步数据。这个奖项 我将为Clingan博士提供支持，指导和保护时间，这将提高她在加州大学洛杉矶分校的培训 帮助她成为一名独立研究员