Predicting fatal and non-fatal overdose in Los Angeles County with Rapid Overdose Surveillance Dashboard to target street-based addiction treatment and harm reduction services

利用快速过量用药监测仪表板预测洛杉矶县的致命和非致命用药过量，以针对街头成瘾治疗和减少伤害服务

• 批准号: 10741388
• 负责人: David Goodman
• 金额: $ 21.42万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-29 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10741388
• 关键词: Alaska Native; Algorithms; American Indians; Asian; Award; Behavioral; Black Populations; Black race; Bupropion; California; Caring; Cessation of life; Chronic Disease; Classification; Cocaine; Code; Collaborations; County; Data; Data Analyses; Data Sources; Development; Doctor of Philosophy; Electronic Health Record; Emergency department visit; Epidemiologist; Ethnic Origin; Exclusion; Fentanyl; Funding; General Population; Goals; Harm Reduction; Health; Health Services; Healthcare; Helping to End Addiction Long-term; Hispanic; Hospitalization; Illicit Drugs; Individual; International Classification of Disease Codes; International Classification of Diseases; Intervention; K-Series Research Career Programs; Latino; Latinx; Licensing; Los Angeles; Machine Learning; Medical; Medicine; Mental Health Services; Mentors; Mentorship; Methadone; Methamphetamine; Mirtazapine; Naltrexone; National Institute of Drug Abuse; Native Americans; Native-Born; Natural Language Processing; Not Hispanic or Latino; Opioid; Outcome; Overdose; Patient Care; Patients; Persons; Pharmaceutical Preparations; Physicians; Population; Prevention; Provider; Psychologist; Public Health; Race; Receiver Operating Characteristics; Records; Research; Research Design; Research Personnel; Research Project Grants; Science; Scientist; Services; Stimulant; Substance Use Disorder; System; Text; Time; Training; Translating; United States National Institutes of Health; United States Public Health Service; Writing; addiction; analog; care systems; contingency management; dashboard; design; ethnic diversity; examination questions; experience; health assessment; health care model; health care service; health care service utilization; health difference; improved; mortality; neighborhood disadvantage; opioid use; opioid use disorder; outreach; overdose death; parent grant; patient population; polysubstance use; primary care visit; racial diversity; skills; stimulant use; stimulant use disorder; substance use treatment; synthetic opioid; tool

PROJECT SUMMARY This Diversity Supplement is designed to support and enhance the diversity of the health-related research workforce through the training of Sarah Clingan, PhD., a Latinx/Native American Addiction Researcher. The supplement is complementary to the parent grant, an R01 on overdose and opioid use disorder in Los Angeles County, funded under the National Institutes of Health's Helping End Addiction Long-Term Initiative. Dr. Clingan has a strong research background in addiction sciences that will continue to develop under the mentorship of Dr. Chelsea Shover (primary mentor, epidemiologist, and MPI of parent grant), Dr. Steve Shoptaw (senior co-mentor) a licensed psychologist and Director of the Center for Behavioral and Addiction Medicine at UCLA, and Dr. David Goodman-Meza (co-mentor, physician-scientist, and MPI of parent grant). These three mentors have a strong record of collaboration and a track record of mentoring underrepresented scholars. Through this supplement, Dr. Clingan will obtain training and mentorship across three training objectives. The first will focus on gaining skills and experience using natural language processing (NLP) and machine learning approaches. She will additionally gain skills in designing research projects using real-world data to study polysubstance use. Her third and final training objective is professional development activities that will culminate in her writing a K01 career development award, using the findings generated by the Diversity Supplement as pilot data. The research component of the Diversity Supplement will use electronic health record (EHR) data collected via the parent grant to identify people with polysubstance use and create models of healthcare utilization among those who co-use opioids and stimulants. Specifically, the aims of the Diversity Supplement research plan are to: 1) develop an algorithm to identify people with polysubstance use (opioids and stimulants) in EHR data; 2) Characterize healthcare utilization among those who co-use opioids and stimulants using NLP-based approaches. These results will improve our understanding of polysubstance use in a county with a very high burden of overdose involving fentanyl and stimulants, and contribute to our understanding of the gaps in healthcare services for this population in Los Angeles County. The Diversity Supplement findings will also provide preliminary data for Dr. Clingan's planned K01 application. This award will provide Dr. Clingan with the support, mentorship, and protected time that will enhance her training at UCLA and facilitate her transition to become an independent researcher.

项目概要 该多样性补充材料旨在支持和增强健康相关研究的多样性 劳动力通过拉丁裔/美洲原住民成瘾研究员 Sarah Clingan 博士的培训。这 补助金是对家长补助金的补充，即洛杉矶关于过量和阿片类药物使用障碍的 R01 县，由美国国立卫生研究院帮助戒除成瘾长期计划资助。博士。 Clingan 在成瘾科学方面拥有强大的研究背景，并将在 Chelsea Shover 博士（主要导师、流行病学家、家长资助 MPI）、Steve 博士的指导 Shoptaw（高级联合导师）是一名持证心理学家，也是行为和成瘾中心主任 加州大学洛杉矶分校医学博士和 David Goodman-Meza 博士（共同导师、医师兼科学家、MPI 家长资助）。 这三位导师有着良好的合作记录和指导代表性不足的记录 学者。通过此补充，Clingan 博士将获得三项培训的培训和指导 目标。第一个将侧重于获得使用自然语言处理（NLP）和 机器学习方法。她还将获得使用现实世界设计研究项目的技能 研究多物质使用的数据。她的第三个也是最后一个培训目标是专业发展活动 最终她利用多样性研究的发现撰写了 K01 职业发展奖 作为试点数据的补充。多样性补充的研究部分将使用电子健康 通过家长资助收集的记录 (EHR) 数据，用于识别多物质使用者并创建模型 同时使用阿片类药物和兴奋剂的人的医疗保健利用率。具体而言，多元化的目标 补充研究计划是：1）开发一种算法来识别使用多种物质（阿片类药物）的人 和兴奋剂）在电子病历数据中； 2) 描述同时使用阿片类药物和药物的人的医疗保健利用情况 使用基于 NLP 的方法的兴奋剂。这些结果将提高我们对多物质使用的理解 一个涉及芬太尼和兴奋剂的过量用药负担非常重的县，并为我们的 了解洛杉矶县这一人群的医疗保健服务差距。多样性 补充调查结果还将为 Clingan 博士计划的 K01 申请提供初步数据。本次获奖 将为 Clingan 博士提供支持、指导和受保护的时间，以加强她在加州大学洛杉矶分校的培训 并帮助她过渡成为一名独立研究员。