ECHO DAC (Environmental Influences on Child Health Outcomes Data Analysis Center)

约翰霍普金斯大学和RTI国际的互补专业知识和资源被结合在一起 作为美国国立卫生研究院环境对儿童健康结局的影响(ECHO)队列研究数据分析中心 (DAC)。一个具有信息学、流行病学和生物统计学专业知识的发改委对于有效的纵向分析是必不可少的。 和多层次分析，以阐明生活过程中环境和社会暴露的影响，以及 遗传易感性对儿科健康和不良后果的影响，并注意面向解决方案的研究。 系统增强、安全的计算环境和入职站点的体验将促进 从第一个周期(ECO1)到下一个周期(ECHO2)的高效、有效的过渡。DAC的熟悉度 利用现有的回声站点和数据，可以在实施ECHO2的同时实现持续的生产力。 DAC在开发创新方法分析数据方面独一无二地提供了丰富的经验 完全不同的站点，如回声1所示。DAC将扩大ECHO队列数据的访问和可用性 科学界。为了帮助推动儿科研究中的下一代科学， 流行病学、统计学、信息学、儿科结果、环境暴露和遗传学是协同作用的 为实现这些具体目标：1)提供安全、统一和灵活的中央数据捕获框架和 储存和跟踪生物检疫，并确保高数据质量和保真度；2)提供统计和 在设计、分析和解释研究建议方面的流行病学专业知识，开发创新 和需要的新的分析方法，并在相关内容领域的指导下进行分析 科学家提高ECHO产品的科学严密性和重复性；3)加强研究 基础设施，集成数据标准以支持可查找、可访问、可互操作和可重用(公平) 加速数据共享的原则；4)使用组织、报告和责任结构 发展援助委员会的最佳内部治理以及与ECHO队列研究的其他组成部分的互动 将提高透明度、问责制和清晰的沟通。建议的增强功能、工具和 收集、合并和分析个人、地理、家庭和社会数据的方法发展 将是使ECHO成为具有影响力的儿科健康流行病学研究的首要资源的关键。

The complementary expertise and resources of Johns Hopkins University and RTI International are combined as the NIH Environmental Influences on Child Health Outcomes (ECHO) Cohort Study Data Analysis Center (DAC). A DAC with expertise in informatics, epidemiology and biostatistics is essential for effective longitudinal and multi-level analyses to elucidate the influences of life course environmental and social exposures, and genetic susceptibility on pediatric health and adverse outcomes, with attention to solution-oriented research. System enhancements, a secured computing environment, and experience with on-boarding sites will facilitate an efficient, and effective transition from the first cycle (ECHO1) into the next cycle (ECHO2). DAC’s familiarity with existing ECHO sites and data enables continued productivity concurrent with implementation of ECHO2. DAC uniquely offers deep experience in developing innovative methods for analyzing data combined from disparate sites, as evidenced in ECHO1. DAC will broaden access and useability of ECHO Cohort data to the scientific community. To help drive the next generation science in pediatric research, expertise in epidemiology, statistics, informatics, pediatric outcomes, environmental exposures, and genetics is synergized to realize these specific aims: 1) Provide a secure, uniform and flexible central framework for data capture and storage and tracking of biospecimens, and to ensure high data quality and fidelity; 2) Provide statistical and epidemiological expertise in the design, analysis, and interpretation of research proposals, develop innovative and novel analytical methods where needed, and conduct analyses under direction of relevant content area scientists to enhance the scientific rigor and reproducibility of ECHO products; 3) Enhance research infrastructure, integrate data standards to support findable, accessible, interoperable, and reusable (FAIR) principles to accelerate data sharing; 4) Use an organizational, reporting, and accountability structure for optimal internal governance of the DAC and interaction with other components of the ECHO Cohort Study that will enhance transparency, accountability, and clear communication. The proposed enhancements, tools, and methods development for collecting, combining, and analyzing individual, geographic, family, and social data will be key in making ECHO the premier resource for impactful epidemiological studies of pediatric health.