Pathways to enrolling diverse Latinos in autopsy studies: Insights from a largelongitudinal study

让不同拉丁裔参加尸检研究的途径：大型纵向研究的见解

• 批准号: 10592154
• 负责人: Alejandra Morlett Paredes
• 金额: $ 11.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592154
• 关键词: Age; Aging; Agreement; Altruism; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Attitude; Autopsy; Belief; Brain; California; Chicago; Cognitive; Communities; Complex; Consent; Data; Dementia; Development; Diagnosis; Dimensions; Disparity; Education; Educational Materials; Enrollment; Ensure; Etiology; Face; Focus Groups; Foundations; Funding; Goals; Happiness; Health; High Prevalence; Infrastructure; Intention; Intervention; Investigation; K-Series Research Career Programs; Knowledge; Latino; Latino Population; Lead; Measures; Mediating; Mentored Research Scientist Development Award; Mentors; Methods; Minority; Modeling; Neurocognitive; Neurosciences; Organ Donations; Participant; Pathology; Pathway interactions; Perception; Persons; Pilot Projects; Population; Populations at Risk; Postdoctoral Fellow; Procedures; Process; Productivity; Publications; Questionnaires; Religious Belief; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Sample Size; Scientist; Study of Latinos; Surveys; Techniques; Time; Training; Trust; Underserved Population; Universities; brain tissue; career; career development; cohort; community engagement; design; diagnostic tool; education research; improved; insight; instrument; neuropathology; optimism; pilot test; post intervention; programs; recruit; skills; social culture; symposium

PROJECT ABSTRACT This is an application for a K01 award for Dr. Alejandra Morlett Paredes, a postdoctoral fellow in the Neurosciences department at the University of California, San Diego (UCSD). Dr. Morlett Paredes is establishing herself as a young researcher conducting research to further understand Latino’s intentions to consent and participate in brain donation studies and those that include invasive procedures for Alzheimer’s Disease and Related Dementias (ADRD) research. This K01 award will provide Dr. Morlett Paredes with the support and time necessary to accomplish the following goals: (1) gain proficiency in community engagement and recruitment; (2) gain proficiency in mixed methods and survey research methodologies; (3) gain proficiency in neuropathology of dementias; and (4) to develop grantsmanship and professional skills. To achieve these goals, Dr. Morlett Paredes has assembled an expert mentoring team, including her primary mentor: Dr. Hector M. González (expertise in neuroscience) and co-mentoring team: Drs. Lisa Barnes and David X. Marquez (experts in community-based recruitment with underserved populations), Dr. Mark R. Luborsky (expert in mixed methods and survey development) and Dr. Anne Hiniker (expert in Alzheimer’s disease neuropathology and brain autopsy process). The goal of the proposed project is to develop a survey instrument and culturally-tailored educational material that will measure intention to consent and participate in brain donation studies for ADRD research among older and diverse Latinos. Dr. Morlett Paredes will achieve this goal through the following specific aims: Aim 1: (a) Develop and validate a new questionnaire, informed by the Organ Donation Model, to assess dimensions of older Latinos’ intent to participate in brain donation research amongst community based and UCSD ADRC participants; (b) Design culturally-tailored educational information through use of focus group techniques. Implement the new instrument developed in Aim 1a to pilot test the impact of these materials by comparing pre- and post-intervention scores on attitudes and intention to consent and participate in brain donation research using UCSD ADRC participants and older community-based Latinos from the San Diego area. Aim 2: Implement the new survey instrument in a large cohort of diverse older Latinos from the SOL-INCA to obtain information on attitudes and intention to participate in brain donation research. If validated, this study will be used to develop an R01 to enroll diverse Latinos in autopsy studies at ADRCs across the US proximal to 4 SOL-INCA Field Centers in Bronx, Chicago, Miami, and San Diego, beginning with the UCSD ADRC.

项目摘要 这是一份K 01奖的申请，申请人是美国国家科学院博士后研究员Alejandra Morlett Paredes博士。 加州大学圣地亚哥分校神经科学系。莫莱特·帕雷德斯医生正在建立 她自己作为一名年轻的研究人员进行研究，以进一步了解拉丁美洲人的同意意图， 参与大脑捐赠研究和包括阿尔茨海默病侵入性手术的研究， 相关痴呆症（ADRD）研究。这个K 01奖项将为Morlett Paredes博士提供支持和时间 必须完成以下目标：（1）熟练掌握社区参与和招聘;（2） 熟练掌握混合方法和调查研究方法;（3）熟练掌握神经病理学 （4）发展专业技能。为了实现这些目标，Morlett博士 帕雷德斯组建了一个专家指导团队，其中包括她的主要导师：赫克托M。冈萨雷斯 （神经科学专业知识）和共同指导团队：丽莎巴恩斯和大卫X博士。马奎兹（Marquez） 基于社区的招聘与服务不足的人群），博士马克R。Luborsky（混合方法专家 和调查发展）和安妮·希尼克博士（阿尔茨海默病神经病理学和脑解剖专家 过程）。 拟议项目的目标是开发一种调查工具和适合文化的教育材料 这将衡量同意和参与老年人ADRD研究的大脑捐赠研究的意愿 各种各样的拉丁美洲人。Morlett Paredes博士将通过以下具体目标实现这一目标：目标1：（a） 制定并验证一份新的问卷，以器官捐献模型为依据，评估 老年拉丁美洲人的意图参与大脑捐赠研究之间的社区为基础的和UCSD ADRC （B）通过使用焦点小组技术，设计适合文化的教育信息。 实施目标1a中开发的新工具，通过比较这些材料的预处理效果， 以及干预后对同意和参与大脑捐赠研究的态度和意图的评分 使用UCSD ADRC参与者和来自圣地亚哥地区的老年社区拉丁美洲人。目标2：执行 新的调查工具，在一个大的队列不同的老年拉丁美洲人从SOL-INCA获得信息， 参与脑捐赠研究的态度和意向。如果得到验证，该研究将用于开发 一项R 01，在美国各地接近4个SOL-INCA场的ADRC的尸检研究中招募不同的拉丁美洲人 中心位于布朗克斯、芝加哥、迈阿密和圣地亚哥，从加州大学圣地亚哥分校ADRC开始。