Improving 15-LOX-2 small molecule inhibitors through medicinal chemistry and structure-guided design

该项目旨在通过开发选择性和有效的15-LOX-2抑制剂，特别是能够在体外和体内模型中破坏15-LOX-2/PEBP1蛋白复合物并调节铁凋亡的抑制剂，来建立先前的筛选工作。

This project aims to build on previous screening work by developing selective and potent 15-LOX-2 inhibitors, specifically ones capable of disrupting the 15-LOX-2/PEBP1 protein-protein complex and modulate ferroptosis both in in vitro and in vivo models. During this period, the collaborative team worked to outline a research plan to accomplish the stated project goals. Initial work was done to design and develop potential cell-based assays, and medicinal chemistry strategies were discussed for the current 15-LOX-2 inhibitor leads. The project team has identified a small molecule that inhibits ferroptosis, and is currently pursuing analogs of the chemotype.