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Base Title: PREVENT Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint BiomarkersTask Order Title: Colorectal Cancer (CRC) Prevention by TPST-1495 in PIRC rat mod

Base Title: PREVENT Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint BiomarkersTask Order Title: Colorectal Cancer (CRC) Prevention by TPST-1495 in PIRC rat mod
基本标题：预防临床前药物开发计划：临床前功效和中间终点生物标志物任务顺序标题：TPST-1495 在 PIRC 大鼠模型中预防结直肠癌 (CRC)
批准号：
10927554
负责人：
CHINTHALAPALLY RAO
金额：
$114.04万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-09-11 至 2026-09-10
来源：
https://reporter.nih.gov/project-details/10927554
关键词：
American Association of Cancer ResearchAnimal Cancer ModelAnimalsApoptosisBiological MarkersBlood Chemical AnalysisBody WaterBody WeightCell ProliferationChemopreventive AgentColonColon CarcinomaColonic PolypsColonoscopyColorectal NeoplasmsCommunitiesConsultationsContractorContractsDevelopmentDinoprostoneDoseFamilial Adenomatous Polyposis SyndromeFundingGovernmentHistologyHuman ResourcesInbred F344 RatsIncidenceInflammationKidneyLiteratureLiverLungMalignant NeoplasmsMeasurementMeasuresMissionModelingMonitorNotificationOralOral AdministrationOrganPathway interactionsPlasmaPolypsPreclinical Drug DevelopmentPrincipal InvestigatorProgram DevelopmentProgress ReportsRattusReportingResearchSafetySamplingScheduleSignal PathwaySlideSmall Intestinal PolypSpleenSulindacTechnologyTestingToxic effectToxicologyTravelTumor BurdenWFDC2 geneWater consumptionWorkbasecancer preventioncarcinogenesisclinical translationcolorectal cancer preventionefficacy evaluationefficacy studyimmunoregulationinnovationmeetingsneoplastic cellnovelposterspreclinical efficacypredictive markerpreventive interventionprogramsresearch and developmentsymposiumtreatment durationtumorvaccinology

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中文摘要
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英文摘要
The purpose of this Task Order is to evaluate the efficacy and preliminary safety of TPST-1495 for the prevention of Colorectal Cancer (CRC) associated with Familial Adenomatous Polyposis (FAP) in PIRC rat model. The Government will provide TPST-1495 to the Contractor for use under the effort described in the Statement of Work.
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