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Molecular Heterogeneity of Inflammation and Growth Factor Pathways in Sporadic and Syndromic Colon Cancers: Implications for Prevention and Therapeutic TrialsPOP: 09/15/2014-09/14/2015

Molecular Heterogeneity of Inflammation and Growth Factor Pathways in Sporadic and Syndromic Colon Cancers: Implications for Prevention and Therapeutic TrialsPOP: 09/15/2014-09/14/2015
散发性和综合征性结肠癌中炎症和生长因子途径的分子异质性：对预防和治疗试验的影响POP：09/15/2014-09/14/2015
批准号：
8944482
负责人：
CHINTHALAPALLY RAO
金额：
$48.2万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-09-15 至 2015-09-14
来源：
https://reporter.nih.gov/project-details/8944482
关键词：
AddressAftercareCandidate Disease GeneChemopreventionChemopreventive AgentClinical ChemopreventionClinical TrialsColon CarcinomaColonic PolypsContractorContractsDrug effect disorderEnsureErlotinibGene ExpressionGenesGoalsGrowth FactorHeterogeneityHistologicIndividualInflammationMolecularMucous MembraneMutateMutationNormal tissue morphologyParticipantPathway interactionsPatientsPhase II Clinical TrialsPlacebo ControlPolypsPreventionProcessRandomizedResistanceSamplingSourceSulindacTherapeuticTissuescolon carcinogenesisgenetic analysisgenetic pedigreeoverexpression

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英文摘要
The contract is to perform molecular analyses on pre- and post-treatment duodenal and colonic polyps as well as histologically normal tissue from FAP/AFAP participants in an existing randomized, placebo-controlled, phase II clinical trial of sulindac and erlotinib or other appropriately selected chemopreventive agents. The ultimate goal shall be to correlate the pathways that contain these markers with mechanisms of colon carcinogenesis and of drug action in inhibiting this process.
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