GDM sub-study of Fetal Growth Studies

GDM 胎儿生长研究的子研究

• 批准号: 10928028
• 负责人: Zhen Chen
• 金额: $ 8.22万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10928028
• 关键词: American; Body fat; Clinical Endocrinology; Clinical Nutrition; Data; Development; Diabetes Mellitus; Endocrinology; Epidemiology; Etiology; Fetal Growth; First Pregnancy Trimester; Functional disorder; Future; Gestational Diabetes; Glycosylated hemoglobin A; Growth Factor; Insulin; International; Investigation; Journals; Length; Life Style; Lipids; Metabolic; Nested Case-Control Study; Nutrient; Nutritional; Obesity; Outcome; Pathway interactions; Physiological; Pregnancy; Pregnant Women; Reporting; Research; Risk; Risk Factors; Role; Saturated Fatty Acids; Thyroid Function Tests; Thyroid Gland; Vitamin D; Woman; Work; adipokines; adverse pregnancy outcome; biomarker panel; cardiometabolism; improved; insight; iron metabolism; longitudinal, prospective study; metabolomics; screening; telomere

This is a prospective study of longitudinal risk factors of gestational diabetes mellitus (GDM) and a nested case control study of a comprehensive panel of biomarkers including metabolomics profiles focusing on the etiology and prediction of GDM and its implications for fetal growth. Initial findings indicated potential important roles of insulin growth factor (IGF) pathway (Zhu et al. Diabetes 2016), iron metabolism (Rawal et al Diabetologia 2017), lipids (Bao et al. Journal of Diabetes 2017), saturated fatty acids (Zhu et al. American Journal of Clinical Nutrition 2018), thyroid function markers (Rawal et al. Journal of Clinical Endocrinology and Metabolism 2018) and telomere length (Lin et al. Epidemiology 2018) during as early as the first trimester in the development of GDM. For instance, it was discovered that thyroid function in pregnant women may be involved in the pathophysiology of GDM (Rawal et al. Journal of Clinical Endocrinology and Metabolism 2018). These findings, in conjunction with previous evidence of thyroid-related adverse pregnancy outcomes, support the potential benefits of thyroid screening among pregnant women. In addition, a significantly increased risk of GDM was observed in association with saturated fatty acid levels as early as the first trimester of pregnancy (Zhu et al. American Journal of Clinical Nutrition 2018), providing impetus for future investigations that target circulating saturated fatty acids in pregnant women to improve our understanding of their distinct nutritional, metabolic, and physiologic roles in cardiometabolic outcomes. Recently, new research also discovered that HbA1C levels potentially can help identify women at risk for GDM early in pregnancy, when lifestyle changes may be more effective in reducing their risk (Hinkle et al. Scientific Reports 2018). Furthermore, new research found that womens adipokine levels (Hinkle et al. International Journal of Obesity 2018) and vitamin D status (Francis et al. Nutrients 2018) in pregnancy appear to be involved in regulating fetal growth. While more work is needed, the data offer insight into how maternal body fat composition may influence different aspects of fetal growth.

这是一项关于妊娠期糖尿病（GDM）纵向危险因素的前瞻性研究，以及一项包括代谢组学在内的生物标志物综合小组的巢式病例对照研究，重点关注GDM的病因和预测及其对胎儿生长的影响。初步发现表明胰岛素生长因子（IGF）通路可能发挥重要作用（Zhu等）。糖尿病2016)，铁代谢（Rawal et al diabetologi2017），脂质（Bao et al.）。Journal of Diabetes, 2017)，饱和脂肪酸(Zhu et al.；美国临床营养学杂志2018)，甲状腺功能标志物(Rawal等。临床内分泌与代谢杂志2018)和端粒长度(Lin et al.；《流行病学》（2018），早在GDM发展的前三个月。