Impact of Parental Long Term Thermoneutral Ambient Temperature on Offspring Health

亲代长期热中性环境温度对后代健康的影响

• 批准号: 10929248
• 负责人: Umesh D Wankhade
• 金额: $ 18.82万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10929248
• 关键词: Adipocytes; Adipose tissue; Blood Vessels; Country; Data; Exposure to; Gene Expression; Health; Housing; Immune response; Impairment; Income; Inflammation; Inflammatory; Inflammatory Response; Intervention; Metabolic; Morphology; Obesity; Outcome; Parents; Pilot Projects; Predisposition; Public Health; Risk Reduction; Temperature; Weight Gain; cold temperature; improved; next generation; obesity in children; obesity prevention; obesity risk; offspring; parental role; programs

The first objective is to determine how multi-generational ambient temperature, specifically thermoneutral temperature, modulates the metabolic health of parents and subsequently programs the metabolic health of the next generation. The hypothesis is that prolonged exposure to thermoneutral ambient temperature will lead to dysfunctional adipose tissue and impair the metabolic health of parents, resulting in an increased predisposition to obesity in the offspring. Preliminary data from pilot studies have already shown significant changes in the weight gain ability and adipose tissue morphology of offspring born to thermoneutral temperature housed parents to that offspring born to cold temperature housed parents. The second objective aims to identify the impact of parental housing temperature on the inflammatory profile of offspring adipose tissue, with a focus on understanding the role of parental temperature exposure in modulating adipose tissue inflammation programming. It is hypothesized that the inflammatory response in offspring adipose tissue will differ between adipocytes and the stromal vascular fraction based on parental housing temperature. Preliminary data showed that changes in parental ambient temperature resulted in changes in the expression of genes involved in immune response in offspring adipose tissue. By pursuing these specific aims, we aim to gain a better understanding of how ambient temperature modulation during parental stages influences the metabolic programming of offspring. The findings have the potential to uncover new mechanisms and interventions to reduce the risk of obesity and associated health complications, ultimately contributing to improved public health outcomes in high-income countries.

第一个目标是确定多代环境温度，特别是热中性温度，如何调节父母的代谢健康，并随后规划下一代的代谢健康。该假说认为，长时间暴露于热中性环境温度将导致脂肪组织功能失调，损害父母的代谢健康，导致后代肥胖的倾向增加。试点研究的初步数据已经显示， 在体重增加能力和脂肪组织形态的变化所生的后代，以热中性温度圈养的父母，以寒冷的温度所生的后代。第二个目的是确定父母房屋温度对后代脂肪组织炎症特征的影响，重点是了解父母温度暴露在 调节脂肪组织炎症编程。假设后代脂肪组织中的炎症反应在脂肪细胞和基质血管组分之间将基于亲代饲养温度而不同。初步数据显示，亲代环境温度的变化导致后代脂肪组织中参与免疫反应的基因表达发生变化。通过追求这些具体目标，我们的目标是更好地了解环境温度调制过程中， 亲代阶段影响后代的代谢程序。这些发现有可能揭示新的机制和干预措施，以降低肥胖和相关健康并发症的风险，最终有助于改善高收入国家的公共卫生结果。