SBIR TOPIC 425 PHASE I: POSTURE ANALYSIS THROUGH MACHINE LEARNING (PATHML)
SBIR 主题 425 第一阶段:通过机器学习进行姿势分析 (PATHML)
基本信息
- 批准号:10931985
- 负责人:
- 金额:$ 35.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-27 至 2024-02-26
- 项目状态:已结题
- 来源:
- 关键词:Biological MarkersBreast Cancer PatientCancer PatientComparative StudyComplementConsensusDataDetectionDevelopmentDiagnosticDiagnostic testsDiamondLifeMachine LearningMagnetic nanoparticlesMagnetometriesMethodsMicroRNAsMonitorNitrogenOpticsParaffin EmbeddingPatternPerformancePhasePostureRNA SequencesReportingResearchReverse Transcriptase Polymerase Chain ReactionSmall Business Innovation Research GrantSpecific qualifier valueTechnologyTimeTissue EmbeddingUntranslated RNAadvanced breast canceraggressive breast cancercancer biomarkersdetection limitinflammatory breast cancermagnetic fieldmolecular markernanodiamondpoint of carepredictive signaturequantum
项目摘要
Inflammatory breast cancer, (IBC), is a rare and highly aggressive subtype of advanced breast cancer. Small, non-coding RNAs, microRNAs or miRs, are molecular biomarkers for IBC although there is no consensus miR pattern for IBC. RT-PCR, the gold standard for miR profiling, has identified a 5-miR signature predictive of IBC aggressiveness. Other technologies are still needed that can confirm these results and complement (or even supplant) RT-PCR methods. This project will use Diamond Magnetometry (DM) as an advanced quantum-based, all-optical technology for rapid, ultrasensitive sensing of molecules. DM uses fluorescent, nitrogen-vacancy center nanodiamonds (FNDs) to sense/detect very weak magnetic fields. In Objective 1, we will exploit FNDs and magnetic nanoparticles to detect three of the five miR biomarkers of IBC using a microchannel format. In Objective 2, we will determine performance parameters for DM and demonstrate the technology using FFPE from normal and breast cancer patients. This will include a comparison of DM to RT-PCR. Sensing miR targets with DM will be transformative and radically alter how we use and monitor cancer biomarkers. Development of this quantum-based technology will reduce diagnostic testing time from days to minutes, and make real-time, point of care possible, saving money, time, and lives.
炎症性乳腺癌(IBC)是一种罕见且高度侵袭性的晚期乳腺癌亚型。小的非编码 RNA、microRNA 或 miR 是 IBC 的分子生物标志物,尽管 IBC 没有一致的 miR 模式。 RT-PCR 是 miR 分析的黄金标准,已鉴定出可预测 IBC 侵袭性的 5-miR 特征。仍然需要其他技术来证实这些结果并补充(甚至取代)RT-PCR 方法。该项目将使用金刚石磁力计 (DM) 作为一种先进的基于量子的全光学技术,用于快速、超灵敏的分子传感。 DM 使用荧光氮空位中心纳米金刚石 (FND) 来感测/检测非常弱的磁场。在目标 1 中,我们将利用 FND 和磁性纳米颗粒以微通道形式检测 IBC 的 5 种 miR 生物标志物中的 3 种。在目标 2 中,我们将确定 DM 的性能参数,并使用来自正常和乳腺癌患者的 FFPE 演示该技术。这将包括 DM 与 RT-PCR 的比较。通过 DM 检测 miR 靶点将带来变革,并从根本上改变我们使用和监测癌症生物标志物的方式。这种基于量子的技术的开发将把诊断测试时间从几天缩短到几分钟,并使实时护理成为可能,从而节省金钱、时间和生命。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ARFAAN RAMPERSAUD其他文献
ARFAAN RAMPERSAUD的其他文献
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{{ truncateString('ARFAAN RAMPERSAUD', 18)}}的其他基金
FLUORESCENT NANODIAMONDS FOR IN VITRO AND IN VIVO BIOLOGICAL IMAGING- SBIR TOPIC
用于体外和体内生物成像的荧光纳米金刚石 - SBIR 主题
- 批准号:
8755672 - 财政年份:2013
- 资助金额:
$ 35.5万 - 项目类别:
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